Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing

Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin modifications to promote gene silencing. Here the authors use reversible tethering of Polycomb proteins to ectopic sites in mouse ESCs and find that canonical but not variant PRC1 can trigger sequence-independent propagation of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hagar F. Moussa, Daniel Bsteh, Ramesh Yelagandula, Carina Pribitzer, Karin Stecher, Katarina Bartalska, Luca Michetti, Jingkui Wang, Jorge A. Zepeda-Martinez, Ulrich Elling, Jacob I. Stuckey, Lindsey I. James, Stephen V. Frye, Oliver Bell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3dcbf63ea4b486cbed795c1f715237f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c3dcbf63ea4b486cbed795c1f715237f
record_format	dspace
spelling	oai:doaj.org-article:c3dcbf63ea4b486cbed795c1f715237f2021-12-02T15:36:20ZCanonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing10.1038/s41467-019-09628-62041-1723https://doaj.org/article/c3dcbf63ea4b486cbed795c1f715237f2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09628-6https://doaj.org/toc/2041-1723Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin modifications to promote gene silencing. Here the authors use reversible tethering of Polycomb proteins to ectopic sites in mouse ESCs and find that canonical but not variant PRC1 can trigger sequence-independent propagation of Polycomb-mediated transcriptional repression.Hagar F. MoussaDaniel BstehRamesh YelagandulaCarina PribitzerKarin StecherKatarina BartalskaLuca MichettiJingkui WangJorge A. Zepeda-MartinezUlrich EllingJacob I. StuckeyLindsey I. JamesStephen V. FryeOliver BellNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hagar F. Moussa Daniel Bsteh Ramesh Yelagandula Carina Pribitzer Karin Stecher Katarina Bartalska Luca Michetti Jingkui Wang Jorge A. Zepeda-Martinez Ulrich Elling Jacob I. Stuckey Lindsey I. James Stephen V. Frye Oliver Bell Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
description	Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin modifications to promote gene silencing. Here the authors use reversible tethering of Polycomb proteins to ectopic sites in mouse ESCs and find that canonical but not variant PRC1 can trigger sequence-independent propagation of Polycomb-mediated transcriptional repression.
format	article
author	Hagar F. Moussa Daniel Bsteh Ramesh Yelagandula Carina Pribitzer Karin Stecher Katarina Bartalska Luca Michetti Jingkui Wang Jorge A. Zepeda-Martinez Ulrich Elling Jacob I. Stuckey Lindsey I. James Stephen V. Frye Oliver Bell
author_facet	Hagar F. Moussa Daniel Bsteh Ramesh Yelagandula Carina Pribitzer Karin Stecher Katarina Bartalska Luca Michetti Jingkui Wang Jorge A. Zepeda-Martinez Ulrich Elling Jacob I. Stuckey Lindsey I. James Stephen V. Frye Oliver Bell
author_sort	Hagar F. Moussa
title	Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
title_short	Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
title_full	Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
title_fullStr	Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
title_full_unstemmed	Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
title_sort	canonical prc1 controls sequence-independent propagation of polycomb-mediated gene silencing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c3dcbf63ea4b486cbed795c1f715237f
work_keys_str_mv	AT hagarfmoussa canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT danielbsteh canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT rameshyelagandula canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT carinapribitzer canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT karinstecher canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT katarinabartalska canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT lucamichetti canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT jingkuiwang canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT jorgeazepedamartinez canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT ulrichelling canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT jacobistuckey canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT lindseyijames canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT stephenvfrye canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing AT oliverbell canonicalprc1controlssequenceindependentpropagationofpolycombmediatedgenesilencing
_version_	1718386316548243456

Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing

Ejemplares similares