An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy

An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy

Hunter et al. engineer a high affinity, soluble variant of leukemia inhibitory factor receptor (LIFR) to serve as a ligand trap for the LIF cytokine. They further demonstrate that this engineered LIFR exhibits improved affinity relative to the wild-type receptor, leading to better disruption of LIF...

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Autores principales: Sean A. Hunter, Brianna J. McIntosh, Yu Shi, R. Andres Parra Sperberg, Chie Funatogawa, Louai Labanieh, Erin Soon, Hannah C. Wastyk, Nishant Mehta, Catherine Carter, Tony Hunter, Jennifer R. Cochran
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/c3dd515a153e4ff89d47ae646b6e90b2
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spelling oai:doaj.org-article:c3dd515a153e4ff89d47ae646b6e90b22021-12-02T14:26:12ZAn engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy10.1038/s42003-021-01928-22399-3642https://doaj.org/article/c3dd515a153e4ff89d47ae646b6e90b22021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01928-2https://doaj.org/toc/2399-3642Hunter et al. engineer a high affinity, soluble variant of leukemia inhibitory factor receptor (LIFR) to serve as a ligand trap for the LIF cytokine. They further demonstrate that this engineered LIFR exhibits improved affinity relative to the wild-type receptor, leading to better disruption of LIF signaling in cancer cells, and highlighting promise of such ligand traps as therapeutic strategy for cancer treatment.Sean A. HunterBrianna J. McIntoshYu ShiR. Andres Parra SperbergChie FunatogawaLouai LabaniehErin SoonHannah C. WastykNishant MehtaCatherine CarterTony HunterJennifer R. CochranNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Sean A. Hunter
Brianna J. McIntosh
Yu Shi
R. Andres Parra Sperberg
Chie Funatogawa
Louai Labanieh
Erin Soon
Hannah C. Wastyk
Nishant Mehta
Catherine Carter
Tony Hunter
Jennifer R. Cochran
An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy
description Hunter et al. engineer a high affinity, soluble variant of leukemia inhibitory factor receptor (LIFR) to serve as a ligand trap for the LIF cytokine. They further demonstrate that this engineered LIFR exhibits improved affinity relative to the wild-type receptor, leading to better disruption of LIF signaling in cancer cells, and highlighting promise of such ligand traps as therapeutic strategy for cancer treatment.
format article
author Sean A. Hunter
Brianna J. McIntosh
Yu Shi
R. Andres Parra Sperberg
Chie Funatogawa
Louai Labanieh
Erin Soon
Hannah C. Wastyk
Nishant Mehta
Catherine Carter
Tony Hunter
Jennifer R. Cochran
author_facet Sean A. Hunter
Brianna J. McIntosh
Yu Shi
R. Andres Parra Sperberg
Chie Funatogawa
Louai Labanieh
Erin Soon
Hannah C. Wastyk
Nishant Mehta
Catherine Carter
Tony Hunter
Jennifer R. Cochran
author_sort Sean A. Hunter
title An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy
title_short An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy
title_full An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy
title_fullStr An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy
title_full_unstemmed An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy
title_sort engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c3dd515a153e4ff89d47ae646b6e90b2
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