Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication

Influenza A virus packaging depends on interactions between nucleoprotein (NP) and viral RNA (vRNA), but the pattern of NP binding is unclear. Using PAR-CLIP, Williams et al. here show that NP binds vRNA non-uniformly and that RNA structures in low-NP binding regions are important for packaging.

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Autores principales:	Graham D. Williams, Dana Townsend, Kristine M. Wylie, Preston J. Kim, Gaya K. Amarasinghe, Sebla B. Kutluay, Adrianus C. M. Boon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3e0ec1ba76840338009644e276efc59
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spelling	oai:doaj.org-article:c3e0ec1ba76840338009644e276efc592021-12-02T14:39:47ZNucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication10.1038/s41467-018-02886-w2041-1723https://doaj.org/article/c3e0ec1ba76840338009644e276efc592018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02886-whttps://doaj.org/toc/2041-1723Influenza A virus packaging depends on interactions between nucleoprotein (NP) and viral RNA (vRNA), but the pattern of NP binding is unclear. Using PAR-CLIP, Williams et al. here show that NP binds vRNA non-uniformly and that RNA structures in low-NP binding regions are important for packaging.Graham D. WilliamsDana TownsendKristine M. WyliePreston J. KimGaya K. AmarasingheSebla B. KutluayAdrianus C. M. BoonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Graham D. Williams Dana Townsend Kristine M. Wylie Preston J. Kim Gaya K. Amarasinghe Sebla B. Kutluay Adrianus C. M. Boon Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication
description	Influenza A virus packaging depends on interactions between nucleoprotein (NP) and viral RNA (vRNA), but the pattern of NP binding is unclear. Using PAR-CLIP, Williams et al. here show that NP binds vRNA non-uniformly and that RNA structures in low-NP binding regions are important for packaging.
format	article
author	Graham D. Williams Dana Townsend Kristine M. Wylie Preston J. Kim Gaya K. Amarasinghe Sebla B. Kutluay Adrianus C. M. Boon
author_facet	Graham D. Williams Dana Townsend Kristine M. Wylie Preston J. Kim Gaya K. Amarasinghe Sebla B. Kutluay Adrianus C. M. Boon
author_sort	Graham D. Williams
title	Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication
title_short	Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication
title_full	Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication
title_fullStr	Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication
title_full_unstemmed	Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication
title_sort	nucleotide resolution mapping of influenza a virus nucleoprotein-rna interactions reveals rna features required for replication
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c3e0ec1ba76840338009644e276efc59
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Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication

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