Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities.

<h4>Background/aim</h4>Although it has been hypothesized that muscle metabolism and fatigability could be impaired in sickle cell patients, no study has addressed this issue.<h4>Methods</h4>We compared muscle metabolism and function (muscle microvascular oxygenation, microvas...

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Autores principales:	Xavier Waltz, Aurélien Pichon, Nathalie Lemonne, Danièle Mougenel, Marie-Laure Lalanne-Mistrih, Yann Lamarre, Vanessa Tarer, Benoit Tressières, Maryse Etienne-Julan, Marie-Dominique Hardy-Dessources, Olivier Hue, Philippe Connes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c3eba38a6e38492fb90b6121625eeca4
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spelling	oai:doaj.org-article:c3eba38a6e38492fb90b6121625eeca42021-11-18T08:04:09ZNormal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities.1932-620310.1371/journal.pone.0052471https://doaj.org/article/c3eba38a6e38492fb90b6121625eeca42012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23285055/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background/aim</h4>Although it has been hypothesized that muscle metabolism and fatigability could be impaired in sickle cell patients, no study has addressed this issue.<h4>Methods</h4>We compared muscle metabolism and function (muscle microvascular oxygenation, microvascular blood flow, muscle oxygen consumption and muscle microvascular oxygenation variability, which reflects vasomotion activity, maximal muscle force and local muscle fatigability) and the hemorheological profile at rest between 16 healthy subjects (AA), 20 sickle cell-hemoglobin C disease (SC) patients and 16 sickle cell anemia (SS) patients.<h4>Results</h4>Muscle microvascular oxygenation was reduced in SS patients compared to the SC and AA groups and this reduction was not related to hemorhelogical abnormalities. No difference was observed between the three groups for oxygen consumption and vasomotion activity. Muscle microvascular blood flow was higher in SS patients compared to the AA group, and tended to be higher compared to the SC group. Multivariate analysis revealed that muscle oxygen consumption was independently associated with muscle microvascular blood flow in the two sickle cell groups (SC and SS). Finally, despite reduced muscle force in sickle cell patients, their local muscle fatigability was similar to that of the healthy subjects.<h4>Conclusions</h4>Sickle cell patients have normal resting muscle oxygen consumption and fatigability despite hemorheological alterations and, for SS patients only, reduced muscle microvascular oxygenation and increased microvascular blood flow. Two alternative mechanisms can be proposed for SS patients: 1) the increased muscle microvascular blood flow is a way to compensate for the lower muscle microvascular oxygenation to maintain muscle oxygen consumption to normal values or 2) the reduced microvascular oxygenation coupled with a normal resting muscle oxygen consumption could indicate that there is slight hypoxia within the muscle which is not sufficient to limit mitochondrial respiration but increases muscle microvascular blood flow.Xavier WaltzAurélien PichonNathalie LemonneDanièle MougenelMarie-Laure Lalanne-MistrihYann LamarreVanessa TarerBenoit TressièresMaryse Etienne-JulanMarie-Dominique Hardy-DessourcesOlivier HuePhilippe ConnesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52471 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xavier Waltz Aurélien Pichon Nathalie Lemonne Danièle Mougenel Marie-Laure Lalanne-Mistrih Yann Lamarre Vanessa Tarer Benoit Tressières Maryse Etienne-Julan Marie-Dominique Hardy-Dessources Olivier Hue Philippe Connes Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities.
description	<h4>Background/aim</h4>Although it has been hypothesized that muscle metabolism and fatigability could be impaired in sickle cell patients, no study has addressed this issue.<h4>Methods</h4>We compared muscle metabolism and function (muscle microvascular oxygenation, microvascular blood flow, muscle oxygen consumption and muscle microvascular oxygenation variability, which reflects vasomotion activity, maximal muscle force and local muscle fatigability) and the hemorheological profile at rest between 16 healthy subjects (AA), 20 sickle cell-hemoglobin C disease (SC) patients and 16 sickle cell anemia (SS) patients.<h4>Results</h4>Muscle microvascular oxygenation was reduced in SS patients compared to the SC and AA groups and this reduction was not related to hemorhelogical abnormalities. No difference was observed between the three groups for oxygen consumption and vasomotion activity. Muscle microvascular blood flow was higher in SS patients compared to the AA group, and tended to be higher compared to the SC group. Multivariate analysis revealed that muscle oxygen consumption was independently associated with muscle microvascular blood flow in the two sickle cell groups (SC and SS). Finally, despite reduced muscle force in sickle cell patients, their local muscle fatigability was similar to that of the healthy subjects.<h4>Conclusions</h4>Sickle cell patients have normal resting muscle oxygen consumption and fatigability despite hemorheological alterations and, for SS patients only, reduced muscle microvascular oxygenation and increased microvascular blood flow. Two alternative mechanisms can be proposed for SS patients: 1) the increased muscle microvascular blood flow is a way to compensate for the lower muscle microvascular oxygenation to maintain muscle oxygen consumption to normal values or 2) the reduced microvascular oxygenation coupled with a normal resting muscle oxygen consumption could indicate that there is slight hypoxia within the muscle which is not sufficient to limit mitochondrial respiration but increases muscle microvascular blood flow.
format	article
author	Xavier Waltz Aurélien Pichon Nathalie Lemonne Danièle Mougenel Marie-Laure Lalanne-Mistrih Yann Lamarre Vanessa Tarer Benoit Tressières Maryse Etienne-Julan Marie-Dominique Hardy-Dessources Olivier Hue Philippe Connes
author_facet	Xavier Waltz Aurélien Pichon Nathalie Lemonne Danièle Mougenel Marie-Laure Lalanne-Mistrih Yann Lamarre Vanessa Tarer Benoit Tressières Maryse Etienne-Julan Marie-Dominique Hardy-Dessources Olivier Hue Philippe Connes
author_sort	Xavier Waltz
title	Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities.
title_short	Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities.
title_full	Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities.
title_fullStr	Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities.
title_full_unstemmed	Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities.
title_sort	normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c3eba38a6e38492fb90b6121625eeca4
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Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities.

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