Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells
Genetic and epigenetic abnormalities have been found to result from reprogramming of differentiated cells into human induced pluripotent stem cells (hiPSCs). Here, Klawitter et al.identify endogenous L1, Alu and SVA mobilization during reprogramming, highlighting the risk of insertional mutagens in...
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Nature Portfolio
2016
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oai:doaj.org-article:c3ef18eb5c21445d985ad18b9ff23d872021-12-02T17:32:53ZReprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells10.1038/ncomms102862041-1723https://doaj.org/article/c3ef18eb5c21445d985ad18b9ff23d872016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10286https://doaj.org/toc/2041-1723Genetic and epigenetic abnormalities have been found to result from reprogramming of differentiated cells into human induced pluripotent stem cells (hiPSCs). Here, Klawitter et al.identify endogenous L1, Alu and SVA mobilization during reprogramming, highlighting the risk of insertional mutagens in hiPSCs.Sabine KlawitterNina V. FuchsKyle R. UptonMartin Muñoz-LopezRuchi ShuklaJichang WangMarta Garcia-CañadasCesar Lopez-RuizDaniel J. GerhardtAttila SebeIvana GrabundzijaSylvia MerkertPatricia GerdesJ. Andres PulgarinAnja BockUlrike HeldAnett WitthuhnAlexandra HaaseBalázs SarkadiJohannes LöwerErnst J. WolvetangUlrich MartinZoltán IvicsZsuzsanna IzsvákJose L. Garcia-PerezGeoffrey J. FaulknerGerald G. SchumannNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
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Science Q Sabine Klawitter Nina V. Fuchs Kyle R. Upton Martin Muñoz-Lopez Ruchi Shukla Jichang Wang Marta Garcia-Cañadas Cesar Lopez-Ruiz Daniel J. Gerhardt Attila Sebe Ivana Grabundzija Sylvia Merkert Patricia Gerdes J. Andres Pulgarin Anja Bock Ulrike Held Anett Witthuhn Alexandra Haase Balázs Sarkadi Johannes Löwer Ernst J. Wolvetang Ulrich Martin Zoltán Ivics Zsuzsanna Izsvák Jose L. Garcia-Perez Geoffrey J. Faulkner Gerald G. Schumann Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells |
| description |
Genetic and epigenetic abnormalities have been found to result from reprogramming of differentiated cells into human induced pluripotent stem cells (hiPSCs). Here, Klawitter et al.identify endogenous L1, Alu and SVA mobilization during reprogramming, highlighting the risk of insertional mutagens in hiPSCs. |
| format |
article |
| author |
Sabine Klawitter Nina V. Fuchs Kyle R. Upton Martin Muñoz-Lopez Ruchi Shukla Jichang Wang Marta Garcia-Cañadas Cesar Lopez-Ruiz Daniel J. Gerhardt Attila Sebe Ivana Grabundzija Sylvia Merkert Patricia Gerdes J. Andres Pulgarin Anja Bock Ulrike Held Anett Witthuhn Alexandra Haase Balázs Sarkadi Johannes Löwer Ernst J. Wolvetang Ulrich Martin Zoltán Ivics Zsuzsanna Izsvák Jose L. Garcia-Perez Geoffrey J. Faulkner Gerald G. Schumann |
| author_facet |
Sabine Klawitter Nina V. Fuchs Kyle R. Upton Martin Muñoz-Lopez Ruchi Shukla Jichang Wang Marta Garcia-Cañadas Cesar Lopez-Ruiz Daniel J. Gerhardt Attila Sebe Ivana Grabundzija Sylvia Merkert Patricia Gerdes J. Andres Pulgarin Anja Bock Ulrike Held Anett Witthuhn Alexandra Haase Balázs Sarkadi Johannes Löwer Ernst J. Wolvetang Ulrich Martin Zoltán Ivics Zsuzsanna Izsvák Jose L. Garcia-Perez Geoffrey J. Faulkner Gerald G. Schumann |
| author_sort |
Sabine Klawitter |
| title |
Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells |
| title_short |
Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells |
| title_full |
Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells |
| title_fullStr |
Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells |
| title_full_unstemmed |
Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells |
| title_sort |
reprogramming triggers endogenous l1 and alu retrotransposition in human induced pluripotent stem cells |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/c3ef18eb5c21445d985ad18b9ff23d87 |
| work_keys_str_mv |
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