Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study

IntroductionOocyte quality contributes to the development of an optimal embryo and thus a successful pregnancy. The objective of this study was to analyse the association between oocyte cohort quality and the follicular levels of growth hormone (GH), insulin-like growth factor 1 (IGF1), 25-hydroxy v...

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Autores principales:	Florence Scheffler, Albane Vandecandelaere, Marion Soyez, Dorian Bosquet, Elodie Lefranc, Henri Copin, Aviva Devaux, Moncef Benkhalifa, Rosalie Cabry, Rachel Desailloud
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	oocyte morphological abnormality follicular fluid intracytoplasmic sperm injection growth hormone insulin-like growth factor 1 thyroid-stimulating hormone Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/c3eff692c92f42f5b44adfa3ec9d631b
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spelling	oai:doaj.org-article:c3eff692c92f42f5b44adfa3ec9d631b2021-12-02T00:33:43ZFollicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study1664-239210.3389/fendo.2021.793621https://doaj.org/article/c3eff692c92f42f5b44adfa3ec9d631b2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.793621/fullhttps://doaj.org/toc/1664-2392IntroductionOocyte quality contributes to the development of an optimal embryo and thus a successful pregnancy. The objective of this study was to analyse the association between oocyte cohort quality and the follicular levels of growth hormone (GH), insulin-like growth factor 1 (IGF1), 25-hydroxy vitamin D (25OHD), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4) and antithyroid antibodies, as a function of intracytoplasmic sperm injection (ICSI) outcomes.Material and methodsWe conducted a prospective comparative pilot study from January 2013 to December 2017. 59 ICSI cycles constituted an abnormal oocyte cohort (n=34 cycles, in which more than 50% of oocytes presented at least one morphological abnormality) and a normal oocyte cohort (n=25 cycles, in which 50% or less of the oocytes presented at least one morphological abnormality). GH, IGF1, 25OHD, TSH, fT3, fT4 and antithyroid antibodies were measured in follicular fluid.ResultsThe fertilisation rate was lower in the abnormal oocyte cohort (65.5% vs. 80%, respectively, p=0.012). Oocytes’ proportion with at least one abnormality was 79.4% in the abnormal oocyte cohort and 29.0% in the normal oocyte cohort. The mean number of morphological abnormalities per oocyte was significantly higher in the abnormal oocyte cohort. The follicular levels of GH (4.98 vs. 2.75 mIU/L, respectively; p <0.01) and IGF1 (72.1 vs. 54.2 ng/mL, respectively; p=0.05) were higher in the normal oocyte cohort. There was no association with follicular levels of TSH, fT3, fT4, antithyroid antibodies, or 25OHD.ConclusionOocyte cohort quality appears to be associated with follicular levels of GH and IGF1.Florence SchefflerFlorence SchefflerAlbane VandecandelaereMarion SoyezDorian BosquetDorian BosquetElodie LefrancHenri CopinAviva DevauxAviva DevauxMoncef BenkhalifaMoncef BenkhalifaRosalie CabryRosalie CabryRachel DesailloudRachel DesailloudFrontiers Media S.A.articleoocyte morphological abnormalityfollicular fluidintracytoplasmic sperm injectiongrowth hormoneinsulin-like growth factor 1thyroid-stimulating hormoneDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oocyte morphological abnormality follicular fluid intracytoplasmic sperm injection growth hormone insulin-like growth factor 1 thyroid-stimulating hormone Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	oocyte morphological abnormality follicular fluid intracytoplasmic sperm injection growth hormone insulin-like growth factor 1 thyroid-stimulating hormone Diseases of the endocrine glands. Clinical endocrinology RC648-665 Florence Scheffler Florence Scheffler Albane Vandecandelaere Marion Soyez Dorian Bosquet Dorian Bosquet Elodie Lefranc Henri Copin Aviva Devaux Aviva Devaux Moncef Benkhalifa Moncef Benkhalifa Rosalie Cabry Rosalie Cabry Rachel Desailloud Rachel Desailloud Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study
description	IntroductionOocyte quality contributes to the development of an optimal embryo and thus a successful pregnancy. The objective of this study was to analyse the association between oocyte cohort quality and the follicular levels of growth hormone (GH), insulin-like growth factor 1 (IGF1), 25-hydroxy vitamin D (25OHD), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4) and antithyroid antibodies, as a function of intracytoplasmic sperm injection (ICSI) outcomes.Material and methodsWe conducted a prospective comparative pilot study from January 2013 to December 2017. 59 ICSI cycles constituted an abnormal oocyte cohort (n=34 cycles, in which more than 50% of oocytes presented at least one morphological abnormality) and a normal oocyte cohort (n=25 cycles, in which 50% or less of the oocytes presented at least one morphological abnormality). GH, IGF1, 25OHD, TSH, fT3, fT4 and antithyroid antibodies were measured in follicular fluid.ResultsThe fertilisation rate was lower in the abnormal oocyte cohort (65.5% vs. 80%, respectively, p=0.012). Oocytes’ proportion with at least one abnormality was 79.4% in the abnormal oocyte cohort and 29.0% in the normal oocyte cohort. The mean number of morphological abnormalities per oocyte was significantly higher in the abnormal oocyte cohort. The follicular levels of GH (4.98 vs. 2.75 mIU/L, respectively; p <0.01) and IGF1 (72.1 vs. 54.2 ng/mL, respectively; p=0.05) were higher in the normal oocyte cohort. There was no association with follicular levels of TSH, fT3, fT4, antithyroid antibodies, or 25OHD.ConclusionOocyte cohort quality appears to be associated with follicular levels of GH and IGF1.
format	article
author	Florence Scheffler Florence Scheffler Albane Vandecandelaere Marion Soyez Dorian Bosquet Dorian Bosquet Elodie Lefranc Henri Copin Aviva Devaux Aviva Devaux Moncef Benkhalifa Moncef Benkhalifa Rosalie Cabry Rosalie Cabry Rachel Desailloud Rachel Desailloud
author_facet	Florence Scheffler Florence Scheffler Albane Vandecandelaere Marion Soyez Dorian Bosquet Dorian Bosquet Elodie Lefranc Henri Copin Aviva Devaux Aviva Devaux Moncef Benkhalifa Moncef Benkhalifa Rosalie Cabry Rosalie Cabry Rachel Desailloud Rachel Desailloud
author_sort	Florence Scheffler
title	Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study
title_short	Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study
title_full	Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study
title_fullStr	Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study
title_full_unstemmed	Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study
title_sort	follicular gh and igf1 levels are associated with oocyte cohort quality: a pilot study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c3eff692c92f42f5b44adfa3ec9d631b
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Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study

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