Macular edema resolution assessment with implantable dexamethasone in diabetic retinopathy (MERIT): a pilot study

Jay Chhablani, Mahima Jhingan, Abhilash Goud, Kiran Kumar Vupparaboina, Taraprasad Das Smt Kanuri Santhamma Retina Vitreous Centre, LV Prasad Eye Institute, Hyderabad, Telangana, India Purpose: This study aimed to evaluate the effect of dexamethasone implantation on the hard exudates (HEX) in pati...

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Autores principales:	Chhablani J, Jhingan M, Goud A, Vupparaboina KK, Das T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Dexamethasone implant Ozurdex Hard exudates Diabetic macular edema Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c3f16f3caf5f40d29041d431ced83746
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spelling	oai:doaj.org-article:c3f16f3caf5f40d29041d431ced837462021-12-02T00:08:53ZMacular edema resolution assessment with implantable dexamethasone in diabetic retinopathy (MERIT): a pilot study1177-5483https://doaj.org/article/c3f16f3caf5f40d29041d431ced837462018-07-01T00:00:00Zhttps://www.dovepress.com/macular-edema-resolution-assessment-with-implantable-dexamethasone-in--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Jay Chhablani, Mahima Jhingan, Abhilash Goud, Kiran Kumar Vupparaboina, Taraprasad Das Smt Kanuri Santhamma Retina Vitreous Centre, LV Prasad Eye Institute, Hyderabad, Telangana, India Purpose: This study aimed to evaluate the effect of dexamethasone implantation on the hard exudates (HEX) in patients with diabetic macular edema (DME). Study design: This was a nonrandomized open-label single-center prospective trial. Methods: This study included 15 eyes of 11 subjects with DME. Key inclusion criteria were naïve eyes with DME with HEX within 3 mm of fovea with center-involving DME; central macular thickness (CMT) >250 µm at baseline; best-corrected visual acuity (BCVA) between 20/400 and 20/40. Key exclusion criteria were previous intraocular surgery and history of panretinal photocoagulation (PRP) in past 4 months. The primary outcome measure was change in total HEX area at the macula (in mm2) measured by semiautomated algorithm. Secondary outcome measures were change in visual acuity, low-contrast visual acuity (LCVA), retinal sensitivity (RS) on macular microperimetry, and CMT. Results: The total HEX area reduced from 1.5 mm2 (±1.46 mm2) at baseline to 0.89 mm2 (±1.062 mm2) at the final visit (p=0.185). The CMT improved significantly (p=0.03) from 488.67 µm (±240.66 µm) to 326.93 µm (±135.84 µm) at the final visit. Mean BCVA remained stable (p=0.95) (50.93±16.65 at baseline and 50.6±18.95 at final visit). The mean LCVA and RS showed insignificant improvement (p=0.31 and p=0.28, respectively). Conclusion: Our pilot study demonstrated an improving trend in reduction of total HEX area and other anatomical outcomes, with limited functional outcomes. Larger randomized studies with a larger sample size with a control group are warranted to establish management protocols for DME with significant subfoveal HEX. Keywords: dexamethasone implant, Ozurdex, hard exudates, diabetic macular edemaChhablani JJhingan MGoud AVupparaboina KKDas TDove Medical PressarticleDexamethasone implantOzurdexHard exudatesDiabetic macular edemaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1205-1211 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dexamethasone implant Ozurdex Hard exudates Diabetic macular edema Ophthalmology RE1-994
spellingShingle	Dexamethasone implant Ozurdex Hard exudates Diabetic macular edema Ophthalmology RE1-994 Chhablani J Jhingan M Goud A Vupparaboina KK Das T Macular edema resolution assessment with implantable dexamethasone in diabetic retinopathy (MERIT): a pilot study
description	Jay Chhablani, Mahima Jhingan, Abhilash Goud, Kiran Kumar Vupparaboina, Taraprasad Das Smt Kanuri Santhamma Retina Vitreous Centre, LV Prasad Eye Institute, Hyderabad, Telangana, India Purpose: This study aimed to evaluate the effect of dexamethasone implantation on the hard exudates (HEX) in patients with diabetic macular edema (DME). Study design: This was a nonrandomized open-label single-center prospective trial. Methods: This study included 15 eyes of 11 subjects with DME. Key inclusion criteria were naïve eyes with DME with HEX within 3 mm of fovea with center-involving DME; central macular thickness (CMT) >250 µm at baseline; best-corrected visual acuity (BCVA) between 20/400 and 20/40. Key exclusion criteria were previous intraocular surgery and history of panretinal photocoagulation (PRP) in past 4 months. The primary outcome measure was change in total HEX area at the macula (in mm2) measured by semiautomated algorithm. Secondary outcome measures were change in visual acuity, low-contrast visual acuity (LCVA), retinal sensitivity (RS) on macular microperimetry, and CMT. Results: The total HEX area reduced from 1.5 mm2 (±1.46 mm2) at baseline to 0.89 mm2 (±1.062 mm2) at the final visit (p=0.185). The CMT improved significantly (p=0.03) from 488.67 µm (±240.66 µm) to 326.93 µm (±135.84 µm) at the final visit. Mean BCVA remained stable (p=0.95) (50.93±16.65 at baseline and 50.6±18.95 at final visit). The mean LCVA and RS showed insignificant improvement (p=0.31 and p=0.28, respectively). Conclusion: Our pilot study demonstrated an improving trend in reduction of total HEX area and other anatomical outcomes, with limited functional outcomes. Larger randomized studies with a larger sample size with a control group are warranted to establish management protocols for DME with significant subfoveal HEX. Keywords: dexamethasone implant, Ozurdex, hard exudates, diabetic macular edema
format	article
author	Chhablani J Jhingan M Goud A Vupparaboina KK Das T
author_facet	Chhablani J Jhingan M Goud A Vupparaboina KK Das T
author_sort	Chhablani J
title	Macular edema resolution assessment with implantable dexamethasone in diabetic retinopathy (MERIT): a pilot study
title_short	Macular edema resolution assessment with implantable dexamethasone in diabetic retinopathy (MERIT): a pilot study
title_full	Macular edema resolution assessment with implantable dexamethasone in diabetic retinopathy (MERIT): a pilot study
title_fullStr	Macular edema resolution assessment with implantable dexamethasone in diabetic retinopathy (MERIT): a pilot study
title_full_unstemmed	Macular edema resolution assessment with implantable dexamethasone in diabetic retinopathy (MERIT): a pilot study
title_sort	macular edema resolution assessment with implantable dexamethasone in diabetic retinopathy (merit): a pilot study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/c3f16f3caf5f40d29041d431ced83746
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_version_	1718403952603561984

Macular edema resolution assessment with implantable dexamethasone in diabetic retinopathy (MERIT): a pilot study

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