Mechanisms of transcriptional control of glucose metabolism in hepatocytes

The hepatic tissue plays a key role in the regulation and maintenance of stable blood glucose levels. The liver is the main gluconeogenesis organ of the body and is under constant hormonal control to determine the metabolic activity of hepatocytes. Hormonal signals trigger multiple post-translationa...

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Autores principales:	Konstantin Y. Kulebyakin, Zhanna A. Akopyan, Tatiana N. Kochegura, Dmitry N. Penkov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2016
Materias:	gluconeogenesis glycolysis transcription factors hepatocytes Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/c3f51866ae9b4cdf907b1081fba75865
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spelling	oai:doaj.org-article:c3f51866ae9b4cdf907b1081fba758652021-11-14T09:00:20ZMechanisms of transcriptional control of glucose metabolism in hepatocytes2072-03512072-037810.14341/DM2003436-40https://doaj.org/article/c3f51866ae9b4cdf907b1081fba758652016-07-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7758https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The hepatic tissue plays a key role in the regulation and maintenance of stable blood glucose levels. The liver is the main gluconeogenesis organ of the body and is under constant hormonal control to determine the metabolic activity of hepatocytes. Hormonal signals trigger multiple post-translational regulatory mechanisms that alter the activity of key enzymes of glucose metabolism. A crucial role in the long-term control of glucose production and metabolism is played by pre-translational regulation at the level of gene expression of metabolic enzymes. There is growing evidence that this regulation, which is realised via control of the activity of transcription factors, provides constant adjustment of the body to changing environmental conditions and that its disruption leads to the development of metabolic diseases associated with insulin resistance. Therefore, the study of transcription factors that regulate glucose metabolism in the liver and the search for mechanisms to control them is of great biomedical importance in the context of metabolic disease treatment research.Konstantin Y. KulebyakinZhanna A. AkopyanTatiana N. KocheguraDmitry N. PenkovEndocrinology Research Centrearticlegluconeogenesisglycolysistranscription factorshepatocytesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 19, Iss 3, Pp 190-198 (2016)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	gluconeogenesis glycolysis transcription factors hepatocytes Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	gluconeogenesis glycolysis transcription factors hepatocytes Nutritional diseases. Deficiency diseases RC620-627 Konstantin Y. Kulebyakin Zhanna A. Akopyan Tatiana N. Kochegura Dmitry N. Penkov Mechanisms of transcriptional control of glucose metabolism in hepatocytes
description	The hepatic tissue plays a key role in the regulation and maintenance of stable blood glucose levels. The liver is the main gluconeogenesis organ of the body and is under constant hormonal control to determine the metabolic activity of hepatocytes. Hormonal signals trigger multiple post-translational regulatory mechanisms that alter the activity of key enzymes of glucose metabolism. A crucial role in the long-term control of glucose production and metabolism is played by pre-translational regulation at the level of gene expression of metabolic enzymes. There is growing evidence that this regulation, which is realised via control of the activity of transcription factors, provides constant adjustment of the body to changing environmental conditions and that its disruption leads to the development of metabolic diseases associated with insulin resistance. Therefore, the study of transcription factors that regulate glucose metabolism in the liver and the search for mechanisms to control them is of great biomedical importance in the context of metabolic disease treatment research.
format	article
author	Konstantin Y. Kulebyakin Zhanna A. Akopyan Tatiana N. Kochegura Dmitry N. Penkov
author_facet	Konstantin Y. Kulebyakin Zhanna A. Akopyan Tatiana N. Kochegura Dmitry N. Penkov
author_sort	Konstantin Y. Kulebyakin
title	Mechanisms of transcriptional control of glucose metabolism in hepatocytes
title_short	Mechanisms of transcriptional control of glucose metabolism in hepatocytes
title_full	Mechanisms of transcriptional control of glucose metabolism in hepatocytes
title_fullStr	Mechanisms of transcriptional control of glucose metabolism in hepatocytes
title_full_unstemmed	Mechanisms of transcriptional control of glucose metabolism in hepatocytes
title_sort	mechanisms of transcriptional control of glucose metabolism in hepatocytes
publisher	Endocrinology Research Centre
publishDate	2016
url	https://doaj.org/article/c3f51866ae9b4cdf907b1081fba75865
work_keys_str_mv	AT konstantinykulebyakin mechanismsoftranscriptionalcontrolofglucosemetabolisminhepatocytes AT zhannaaakopyan mechanismsoftranscriptionalcontrolofglucosemetabolisminhepatocytes AT tatianankochegura mechanismsoftranscriptionalcontrolofglucosemetabolisminhepatocytes AT dmitrynpenkov mechanismsoftranscriptionalcontrolofglucosemetabolisminhepatocytes
_version_	1718429555248594944

Mechanisms of transcriptional control of glucose metabolism in hepatocytes

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