DNA Satellites Are Transcribed as Part of the Non-Coding Genome in Eukaryotes and Bacteria

It has been shown in recent years that many repeated sequences in the genome are expressed as RNA transcripts, although the role of such RNAs is poorly understood. Some isolated and tandem repeats (satellites) have been found to be transcribed, such as mammalian Alu sequences and telomeric/centromer...

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Autores principales:	Juan A. Subirana, Xavier Messeguer
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tandem repeats satellites <i>Caenorhabditis elegans</i> <i>Bacillus coagulans</i> non-coding DNA small RNA Genetics QH426-470
Acceso en línea:	https://doaj.org/article/c3f5381d3dce421187e8027e49cac822
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spelling	oai:doaj.org-article:c3f5381d3dce421187e8027e49cac8222021-11-25T17:40:13ZDNA Satellites Are Transcribed as Part of the Non-Coding Genome in Eukaryotes and Bacteria10.3390/genes121116512073-4425https://doaj.org/article/c3f5381d3dce421187e8027e49cac8222021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1651https://doaj.org/toc/2073-4425It has been shown in recent years that many repeated sequences in the genome are expressed as RNA transcripts, although the role of such RNAs is poorly understood. Some isolated and tandem repeats (satellites) have been found to be transcribed, such as mammalian Alu sequences and telomeric/centromeric satellites in different species. However, there is no detailed study on the eventual transcription of the interspersed satellites found in many species. Therefore, we decided to study for the first time the transcription of the abundant DNA satellites in the bacterium <i>Bacillus coagulans</i> and in the nematode <i>Caenorhabditis elegans</i>. We have updated the data for <i>C. elegans</i> satellites using the latest version of the genome. We analyzed the transcription of satellites in both species in available RNA-seq results and found that they are widely transcribed. Our demonstration that satellite RNAs are transcribed adds a new family of non-coding RNAs. This is a field that requires further investigation and will provide a deeper understanding of gene expression and control.Juan A. SubiranaXavier MesseguerMDPI AGarticletandem repeatssatellites<i>Caenorhabditis elegans</i><i>Bacillus coagulans</i>non-coding DNAsmall RNAGeneticsQH426-470ENGenes, Vol 12, Iss 1651, p 1651 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tandem repeats satellites <i>Caenorhabditis elegans</i> <i>Bacillus coagulans</i> non-coding DNA small RNA Genetics QH426-470
spellingShingle	tandem repeats satellites <i>Caenorhabditis elegans</i> <i>Bacillus coagulans</i> non-coding DNA small RNA Genetics QH426-470 Juan A. Subirana Xavier Messeguer DNA Satellites Are Transcribed as Part of the Non-Coding Genome in Eukaryotes and Bacteria
description	It has been shown in recent years that many repeated sequences in the genome are expressed as RNA transcripts, although the role of such RNAs is poorly understood. Some isolated and tandem repeats (satellites) have been found to be transcribed, such as mammalian Alu sequences and telomeric/centromeric satellites in different species. However, there is no detailed study on the eventual transcription of the interspersed satellites found in many species. Therefore, we decided to study for the first time the transcription of the abundant DNA satellites in the bacterium <i>Bacillus coagulans</i> and in the nematode <i>Caenorhabditis elegans</i>. We have updated the data for <i>C. elegans</i> satellites using the latest version of the genome. We analyzed the transcription of satellites in both species in available RNA-seq results and found that they are widely transcribed. Our demonstration that satellite RNAs are transcribed adds a new family of non-coding RNAs. This is a field that requires further investigation and will provide a deeper understanding of gene expression and control.
format	article
author	Juan A. Subirana Xavier Messeguer
author_facet	Juan A. Subirana Xavier Messeguer
author_sort	Juan A. Subirana
title	DNA Satellites Are Transcribed as Part of the Non-Coding Genome in Eukaryotes and Bacteria
title_short	DNA Satellites Are Transcribed as Part of the Non-Coding Genome in Eukaryotes and Bacteria
title_full	DNA Satellites Are Transcribed as Part of the Non-Coding Genome in Eukaryotes and Bacteria
title_fullStr	DNA Satellites Are Transcribed as Part of the Non-Coding Genome in Eukaryotes and Bacteria
title_full_unstemmed	DNA Satellites Are Transcribed as Part of the Non-Coding Genome in Eukaryotes and Bacteria
title_sort	dna satellites are transcribed as part of the non-coding genome in eukaryotes and bacteria
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c3f5381d3dce421187e8027e49cac822
work_keys_str_mv	AT juanasubirana dnasatellitesaretranscribedaspartofthenoncodinggenomeineukaryotesandbacteria AT xaviermesseguer dnasatellitesaretranscribedaspartofthenoncodinggenomeineukaryotesandbacteria
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DNA Satellites Are Transcribed as Part of the Non-Coding Genome in Eukaryotes and Bacteria

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