Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk

Abstract Soy consumption has received considerable attention for its potential role in reducing cancer incidence and mortality. However, its effects on gastrointestinal (GI) cancer are controversial. Therefore, we performed a meta-analysis to evaluate the association between soy consumption and gast...

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Autores principales:	Demin Lu, Chi Pan, Chenyang Ye, Huijie Duan, Fei Xu, Li Yin, Wei Tian, Suzhan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c3f614ed89884e1d91df6bb849e71b34
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spelling	oai:doaj.org-article:c3f614ed89884e1d91df6bb849e71b342021-12-02T12:30:12ZMeta-analysis of Soy Consumption and Gastrointestinal Cancer Risk10.1038/s41598-017-03692-y2045-2322https://doaj.org/article/c3f614ed89884e1d91df6bb849e71b342017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03692-yhttps://doaj.org/toc/2045-2322Abstract Soy consumption has received considerable attention for its potential role in reducing cancer incidence and mortality. However, its effects on gastrointestinal (GI) cancer are controversial. Therefore, we performed a meta-analysis to evaluate the association between soy consumption and gastrointestinal cancer risk by searching for prospective studies in PubMed, Web of Science, EMBASE and the reference lists of the included articles. The study-specific odds ratio (OR), relative risk (RR) or hazard ratio (HR) estimates and 95% confidence intervals (CIs) were pooled using either a fixed-effect or random-effect model. Twenty-two independent prospective studies were eligible for our meta-analysis, including 21 cohort studies and one nested case-control study. Soy product consumption was inversely associated with the incidence of overall GI cancer (0.857; 95% CI: 0.766, 0.959) and the gastric cancer subgroup (0.847; 95% CI: 0.722, 0.994) but not the colorectal cancer subgroup. After stratifying the results according to gender, an inverse association was observed between soy product intake and the incidence of GI cancer for females (0.711; 95% CI: 0.506, 0.999) but not for males.Demin LuChi PanChenyang YeHuijie DuanFei XuLi YinWei TianSuzhan ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Demin Lu Chi Pan Chenyang Ye Huijie Duan Fei Xu Li Yin Wei Tian Suzhan Zhang Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk
description	Abstract Soy consumption has received considerable attention for its potential role in reducing cancer incidence and mortality. However, its effects on gastrointestinal (GI) cancer are controversial. Therefore, we performed a meta-analysis to evaluate the association between soy consumption and gastrointestinal cancer risk by searching for prospective studies in PubMed, Web of Science, EMBASE and the reference lists of the included articles. The study-specific odds ratio (OR), relative risk (RR) or hazard ratio (HR) estimates and 95% confidence intervals (CIs) were pooled using either a fixed-effect or random-effect model. Twenty-two independent prospective studies were eligible for our meta-analysis, including 21 cohort studies and one nested case-control study. Soy product consumption was inversely associated with the incidence of overall GI cancer (0.857; 95% CI: 0.766, 0.959) and the gastric cancer subgroup (0.847; 95% CI: 0.722, 0.994) but not the colorectal cancer subgroup. After stratifying the results according to gender, an inverse association was observed between soy product intake and the incidence of GI cancer for females (0.711; 95% CI: 0.506, 0.999) but not for males.
format	article
author	Demin Lu Chi Pan Chenyang Ye Huijie Duan Fei Xu Li Yin Wei Tian Suzhan Zhang
author_facet	Demin Lu Chi Pan Chenyang Ye Huijie Duan Fei Xu Li Yin Wei Tian Suzhan Zhang
author_sort	Demin Lu
title	Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk
title_short	Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk
title_full	Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk
title_fullStr	Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk
title_full_unstemmed	Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk
title_sort	meta-analysis of soy consumption and gastrointestinal cancer risk
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c3f614ed89884e1d91df6bb849e71b34
work_keys_str_mv	AT deminlu metaanalysisofsoyconsumptionandgastrointestinalcancerrisk AT chipan metaanalysisofsoyconsumptionandgastrointestinalcancerrisk AT chenyangye metaanalysisofsoyconsumptionandgastrointestinalcancerrisk AT huijieduan metaanalysisofsoyconsumptionandgastrointestinalcancerrisk AT feixu metaanalysisofsoyconsumptionandgastrointestinalcancerrisk AT liyin metaanalysisofsoyconsumptionandgastrointestinalcancerrisk AT weitian metaanalysisofsoyconsumptionandgastrointestinalcancerrisk AT suzhanzhang metaanalysisofsoyconsumptionandgastrointestinalcancerrisk
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Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk

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