Microglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice

Morroniside, a secoiridoid glycoside from Cornus officinalis, is a class of small molecule non-peptide glucagon-like peptide-1 receptor (GLP-1R) agonists and possess many important biomedical functions. Our previous studies reported that GLP-1R agonist exenatide promoted M2 polarization and the expr...

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Autores principales:	Hao Liu, Mei-Xian Ou, Qiao-Qiao Han
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	morroniside interleukin-10 M2 polarization middle cerebral artery occlusion ischemic stroke Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c3f753cdd8144e48a67486ba9f80fb6f
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spelling	oai:doaj.org-article:c3f753cdd8144e48a67486ba9f80fb6f2021-11-19T07:46:12ZMicroglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice1663-981210.3389/fphar.2021.784329https://doaj.org/article/c3f753cdd8144e48a67486ba9f80fb6f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.784329/fullhttps://doaj.org/toc/1663-9812Morroniside, a secoiridoid glycoside from Cornus officinalis, is a class of small molecule non-peptide glucagon-like peptide-1 receptor (GLP-1R) agonists and possess many important biomedical functions. Our previous studies reported that GLP-1R agonist exenatide promoted M2 polarization and the expression of cell-specific anti-inflammatory factor interleukin-10 in neuropathological pain model. In this study, we proved that morroniside not only induced M2 polarization and stimulated interleukin-10 expression specifically in cortical primary microglia by p38β mitogen-activated protein kinases pathway but also protected nerve cells against H2O2-induced cell oxidative damage and prohibited ischemic injury by reducing infarct size, which is at least in part mediated by enhanced expression of microglial interleukin-10. In the cortical penumbra area in middle cerebral artery occlusion (MCAO) mice. In general, our results indicated that GLP-1R agonist morroniside might play a neuroprotective effect by inducing M2 polarization, and cyclic-AMP/protein kinase A/p38β pathway might mediate morroniside-induced expression of interleukin-10 protein in M2 microglia.Hao LiuMei-Xian OuQiao-Qiao HanFrontiers Media S.A.articlemorronisideinterleukin-10M2 polarizationmiddle cerebral artery occlusionischemic strokeTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	morroniside interleukin-10 M2 polarization middle cerebral artery occlusion ischemic stroke Therapeutics. Pharmacology RM1-950
spellingShingle	morroniside interleukin-10 M2 polarization middle cerebral artery occlusion ischemic stroke Therapeutics. Pharmacology RM1-950 Hao Liu Mei-Xian Ou Qiao-Qiao Han Microglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice
description	Morroniside, a secoiridoid glycoside from Cornus officinalis, is a class of small molecule non-peptide glucagon-like peptide-1 receptor (GLP-1R) agonists and possess many important biomedical functions. Our previous studies reported that GLP-1R agonist exenatide promoted M2 polarization and the expression of cell-specific anti-inflammatory factor interleukin-10 in neuropathological pain model. In this study, we proved that morroniside not only induced M2 polarization and stimulated interleukin-10 expression specifically in cortical primary microglia by p38β mitogen-activated protein kinases pathway but also protected nerve cells against H2O2-induced cell oxidative damage and prohibited ischemic injury by reducing infarct size, which is at least in part mediated by enhanced expression of microglial interleukin-10. In the cortical penumbra area in middle cerebral artery occlusion (MCAO) mice. In general, our results indicated that GLP-1R agonist morroniside might play a neuroprotective effect by inducing M2 polarization, and cyclic-AMP/protein kinase A/p38β pathway might mediate morroniside-induced expression of interleukin-10 protein in M2 microglia.
format	article
author	Hao Liu Mei-Xian Ou Qiao-Qiao Han
author_facet	Hao Liu Mei-Xian Ou Qiao-Qiao Han
author_sort	Hao Liu
title	Microglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice
title_short	Microglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice
title_full	Microglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice
title_fullStr	Microglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice
title_full_unstemmed	Microglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice
title_sort	microglial m2 polarization mediated the neuroprotective effect of morroniside in transient mcao-induced mice
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c3f753cdd8144e48a67486ba9f80fb6f
work_keys_str_mv	AT haoliu microglialm2polarizationmediatedtheneuroprotectiveeffectofmorronisideintransientmcaoinducedmice AT meixianou microglialm2polarizationmediatedtheneuroprotectiveeffectofmorronisideintransientmcaoinducedmice AT qiaoqiaohan microglialm2polarizationmediatedtheneuroprotectiveeffectofmorronisideintransientmcaoinducedmice
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Microglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice

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