Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2

Our aim was to investigate the bone regeneration capacity of powder-type biphasic ceramic scaffold (BCP powder), block-type BCP (BCP block), and collagen-added block-type BCP (BCP collagen) with different concentrations of recombinant human bone morphogenetic protein 2 (rhBMP-2) in an animal model....

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Autores principales:	Ho-Kyung Lim, Ik-Jae Kwon, Sung-Woon On, Seok-Jin Hong, Byoung-Eun Yang, Soung-Min Kim, Jong-Ho Lee, Soo-Hwan Byun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biphasic calcium phosphate block-type biphasic calcium phosphate scaffold collagen recombinant human bone morphogenic protein 2 bone regeneration Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c3f77d5fc4524d8eb53522ba67889972
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spelling	oai:doaj.org-article:c3f77d5fc4524d8eb53522ba678899722021-11-11T16:56:52ZEnhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-210.3390/ijms2221114851422-00671661-6596https://doaj.org/article/c3f77d5fc4524d8eb53522ba678899722021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11485https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Our aim was to investigate the bone regeneration capacity of powder-type biphasic ceramic scaffold (BCP powder), block-type BCP (BCP block), and collagen-added block-type BCP (BCP collagen) with different concentrations of recombinant human bone morphogenetic protein 2 (rhBMP-2) in an animal model. Four rabbits were assigned to each of the following groups: no graft + rhBMP-2 (0.1/0.2 mg/mL), BCP powder + rhBMP-2 (0.1/0.2 mg/mL), BCP block + rhBMP-2 (0.1/0.2 mg/mL), and BCP collagen + rhBMP-2 (0.1/0.2 mg/mL), i.e., a total of 32 rabbits. Polycarbonate tubes (Φ 7 mm × 5 mm) for supporting scaffolds were fixed into a 7 mm round border. Subsequently, 0.1 mL of rhBMP-2 solutions with different concentrations was injected into the tubes. Both radiological and histomorphometric analyses showed that osteogenesis was not enhanced by increasing the concentration of rhBMP-2 in all groups at both 3 and 6 weeks. Radiological analysis showed that bone formation was higher in the BCP collagen group than in the BCP powder and BCP block groups at both rhBMP-2 concentrations at 3 weeks. rhBMP-2 enhanced bone formation; however, as the concentration increased, bone formation could not be enhanced infinitely. Collagen-added alloplastic graft material may be useful for mediating rapid bone formation in initial stages.Ho-Kyung LimIk-Jae KwonSung-Woon OnSeok-Jin HongByoung-Eun YangSoung-Min KimJong-Ho LeeSoo-Hwan ByunMDPI AGarticlebiphasic calcium phosphateblock-type biphasic calcium phosphate scaffoldcollagenrecombinant human bone morphogenic protein 2bone regenerationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11485, p 11485 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biphasic calcium phosphate block-type biphasic calcium phosphate scaffold collagen recombinant human bone morphogenic protein 2 bone regeneration Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	biphasic calcium phosphate block-type biphasic calcium phosphate scaffold collagen recombinant human bone morphogenic protein 2 bone regeneration Biology (General) QH301-705.5 Chemistry QD1-999 Ho-Kyung Lim Ik-Jae Kwon Sung-Woon On Seok-Jin Hong Byoung-Eun Yang Soung-Min Kim Jong-Ho Lee Soo-Hwan Byun Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2
description	Our aim was to investigate the bone regeneration capacity of powder-type biphasic ceramic scaffold (BCP powder), block-type BCP (BCP block), and collagen-added block-type BCP (BCP collagen) with different concentrations of recombinant human bone morphogenetic protein 2 (rhBMP-2) in an animal model. Four rabbits were assigned to each of the following groups: no graft + rhBMP-2 (0.1/0.2 mg/mL), BCP powder + rhBMP-2 (0.1/0.2 mg/mL), BCP block + rhBMP-2 (0.1/0.2 mg/mL), and BCP collagen + rhBMP-2 (0.1/0.2 mg/mL), i.e., a total of 32 rabbits. Polycarbonate tubes (Φ 7 mm × 5 mm) for supporting scaffolds were fixed into a 7 mm round border. Subsequently, 0.1 mL of rhBMP-2 solutions with different concentrations was injected into the tubes. Both radiological and histomorphometric analyses showed that osteogenesis was not enhanced by increasing the concentration of rhBMP-2 in all groups at both 3 and 6 weeks. Radiological analysis showed that bone formation was higher in the BCP collagen group than in the BCP powder and BCP block groups at both rhBMP-2 concentrations at 3 weeks. rhBMP-2 enhanced bone formation; however, as the concentration increased, bone formation could not be enhanced infinitely. Collagen-added alloplastic graft material may be useful for mediating rapid bone formation in initial stages.
format	article
author	Ho-Kyung Lim Ik-Jae Kwon Sung-Woon On Seok-Jin Hong Byoung-Eun Yang Soung-Min Kim Jong-Ho Lee Soo-Hwan Byun
author_facet	Ho-Kyung Lim Ik-Jae Kwon Sung-Woon On Seok-Jin Hong Byoung-Eun Yang Soung-Min Kim Jong-Ho Lee Soo-Hwan Byun
author_sort	Ho-Kyung Lim
title	Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2
title_short	Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2
title_full	Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2
title_fullStr	Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2
title_full_unstemmed	Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2
title_sort	enhanced bone regeneration in variable-type biphasic ceramic phosphate scaffolds using rhbmp-2
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c3f77d5fc4524d8eb53522ba67889972
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_version_	1718432202380804096

Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2

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