Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk.
<h4>Background</h4>Babies born at lower gestational ages or smaller birthweights have a greater risk of poorer health in later life. Both the causes of these sub-optimal birth outcomes and the mechanism by which the effects are transmitted over decades are the subject of extensive study....
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2012
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oai:doaj.org-article:c3f96395fecd46fbbcc0e073db6fbf2f2021-11-18T07:12:58ZTranscriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk.1932-620310.1371/journal.pone.0039744https://doaj.org/article/c3f96395fecd46fbbcc0e073db6fbf2f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22808055/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Babies born at lower gestational ages or smaller birthweights have a greater risk of poorer health in later life. Both the causes of these sub-optimal birth outcomes and the mechanism by which the effects are transmitted over decades are the subject of extensive study. We investigated whether a transcriptomic signature of either birthweight or gestational age could be detected in umbilical cord RNA.<h4>Methods</h4>The gene expression patterns of 32 umbilical cords from Singaporean babies of Chinese ethnicity across a range of birthweights (1698-4151 g) and gestational ages (35-41 weeks) were determined. We confirmed the differential expression pattern by gestational age for 12 genes in a series of 127 umbilical cords of Chinese, Malay and Indian ethnicity.<h4>Results</h4>We found that the transcriptome is substantially influenced by gestational age; but less so by birthweight. We show that some of the expression changes dependent on gestational age are enriched in signal transduction pathways, such as Hedgehog and in genes with roles in cytokine signalling and angiogenesis. We show that some of the gene expression changes we report are reflected in the epigenome.<h4>Conclusions</h4>We studied the umbilical cord which is peripheral to disease susceptible tissues. The results suggest that soma-wide transcriptome changes, preserved at the epigenetic level, may be a mechanism whereby birth outcomes are linked to the risk of adult metabolic and arthritic disease and suggest that greater attention be given to the association between premature birth and later disease risk.Walter StünkelHong PanSiew Boom ChewEmilia TngJun Hao TanLi ChenRoy JosephClara Y CheongMei-Lyn OngYung Seng LeeYap-Seng ChongSeang Mei SawMichael J MeaneyKenneth KwekAllan M SheppardPeter D GluckmanGUSTO Study GroupJoanna D HolbrookPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e39744 (2012) |
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Medicine R Science Q Walter Stünkel Hong Pan Siew Boom Chew Emilia Tng Jun Hao Tan Li Chen Roy Joseph Clara Y Cheong Mei-Lyn Ong Yung Seng Lee Yap-Seng Chong Seang Mei Saw Michael J Meaney Kenneth Kwek Allan M Sheppard Peter D Gluckman GUSTO Study Group Joanna D Holbrook Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk. |
| description |
<h4>Background</h4>Babies born at lower gestational ages or smaller birthweights have a greater risk of poorer health in later life. Both the causes of these sub-optimal birth outcomes and the mechanism by which the effects are transmitted over decades are the subject of extensive study. We investigated whether a transcriptomic signature of either birthweight or gestational age could be detected in umbilical cord RNA.<h4>Methods</h4>The gene expression patterns of 32 umbilical cords from Singaporean babies of Chinese ethnicity across a range of birthweights (1698-4151 g) and gestational ages (35-41 weeks) were determined. We confirmed the differential expression pattern by gestational age for 12 genes in a series of 127 umbilical cords of Chinese, Malay and Indian ethnicity.<h4>Results</h4>We found that the transcriptome is substantially influenced by gestational age; but less so by birthweight. We show that some of the expression changes dependent on gestational age are enriched in signal transduction pathways, such as Hedgehog and in genes with roles in cytokine signalling and angiogenesis. We show that some of the gene expression changes we report are reflected in the epigenome.<h4>Conclusions</h4>We studied the umbilical cord which is peripheral to disease susceptible tissues. The results suggest that soma-wide transcriptome changes, preserved at the epigenetic level, may be a mechanism whereby birth outcomes are linked to the risk of adult metabolic and arthritic disease and suggest that greater attention be given to the association between premature birth and later disease risk. |
| format |
article |
| author |
Walter Stünkel Hong Pan Siew Boom Chew Emilia Tng Jun Hao Tan Li Chen Roy Joseph Clara Y Cheong Mei-Lyn Ong Yung Seng Lee Yap-Seng Chong Seang Mei Saw Michael J Meaney Kenneth Kwek Allan M Sheppard Peter D Gluckman GUSTO Study Group Joanna D Holbrook |
| author_facet |
Walter Stünkel Hong Pan Siew Boom Chew Emilia Tng Jun Hao Tan Li Chen Roy Joseph Clara Y Cheong Mei-Lyn Ong Yung Seng Lee Yap-Seng Chong Seang Mei Saw Michael J Meaney Kenneth Kwek Allan M Sheppard Peter D Gluckman GUSTO Study Group Joanna D Holbrook |
| author_sort |
Walter Stünkel |
| title |
Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk. |
| title_short |
Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk. |
| title_full |
Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk. |
| title_fullStr |
Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk. |
| title_full_unstemmed |
Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk. |
| title_sort |
transcriptome changes affecting hedgehog and cytokine signalling in the umbilical cord: implications for disease risk. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/c3f96395fecd46fbbcc0e073db6fbf2f |
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