IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting

T cell mediated anti-tumour immune responses result in the emergence of an immune-resistant population in a process called immunoediting. Here, the authors show that immunoediting is associated with an increase in genomic rearrangements of tumour cells that requires both cytotoxic T cells and IFNγ e...

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Autores principales:	Kazuyoshi Takeda, Masafumi Nakayama, Yoshihiro Hayakawa, Yuko Kojima, Hiroaki Ikeda, Naoko Imai, Kouetsu Ogasawara, Ko Okumura, David M. Thomas, Mark J. Smyth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3f98c477bbd4b9ea70b9c3d2946b093
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spelling	oai:doaj.org-article:c3f98c477bbd4b9ea70b9c3d2946b0932021-12-02T15:38:51ZIFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting10.1038/ncomms146072041-1723https://doaj.org/article/c3f98c477bbd4b9ea70b9c3d2946b0932017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14607https://doaj.org/toc/2041-1723T cell mediated anti-tumour immune responses result in the emergence of an immune-resistant population in a process called immunoediting. Here, the authors show that immunoediting is associated with an increase in genomic rearrangements of tumour cells that requires both cytotoxic T cells and IFNγ exposure.Kazuyoshi TakedaMasafumi NakayamaYoshihiro HayakawaYuko KojimaHiroaki IkedaNaoko ImaiKouetsu OgasawaraKo OkumuraDavid M. ThomasMark J. SmythNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazuyoshi Takeda Masafumi Nakayama Yoshihiro Hayakawa Yuko Kojima Hiroaki Ikeda Naoko Imai Kouetsu Ogasawara Ko Okumura David M. Thomas Mark J. Smyth IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting
description	T cell mediated anti-tumour immune responses result in the emergence of an immune-resistant population in a process called immunoediting. Here, the authors show that immunoediting is associated with an increase in genomic rearrangements of tumour cells that requires both cytotoxic T cells and IFNγ exposure.
format	article
author	Kazuyoshi Takeda Masafumi Nakayama Yoshihiro Hayakawa Yuko Kojima Hiroaki Ikeda Naoko Imai Kouetsu Ogasawara Ko Okumura David M. Thomas Mark J. Smyth
author_facet	Kazuyoshi Takeda Masafumi Nakayama Yoshihiro Hayakawa Yuko Kojima Hiroaki Ikeda Naoko Imai Kouetsu Ogasawara Ko Okumura David M. Thomas Mark J. Smyth
author_sort	Kazuyoshi Takeda
title	IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting
title_short	IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting
title_full	IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting
title_fullStr	IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting
title_full_unstemmed	IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting
title_sort	ifn-γ is required for cytotoxic t cell-dependent cancer genome immunoediting
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c3f98c477bbd4b9ea70b9c3d2946b093
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IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting

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