A chemical probe based on the PreQ1 metabolite enables transcriptome-wide mapping of binding sites

The small modified nucleotide PreQ1 binds to the PreQ1 riboswitch and regulates gene expression by inducing RNA conformation change. Here the authors design and characterize a specific preQ1-derived probe by x-ray crystallography, mass spectral analysis and transcriptome-wide using Chem-CLIP.

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Detalles Bibliográficos
Autores principales: Sumirtha Balaratnam, Curran Rhodes, Desta Doro Bume, Colleen Connelly, Christopher C. Lai, James A. Kelley, Kamyar Yazdani, Philip J. Homan, Danny Incarnato, Tomoyuki Numata, John S. Schneekloth Jr
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c3fe0cb68393406ba791bbafef33d2f3
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