Potential adverse drug events and its predictors among hospitalized patients at medical center in Ethiopia: a prospective observational study

Abstract Potential adverse drug event (PADE) is a medication error with the potential to cause associate degree injury however that does not cause any injury, either due to specific circumstances, chance, or as a result of the error being intercepted and corrected. This study aimed to assess the inc...

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Autores principales:	Tamiru Sahilu, Mestawet Getachew, Tsegaye Melaku, Tadesse Sheleme, Duresa Abu, Tesfu Zewdu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4027c33e642456ca4ee7e8415ec0952
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spelling	oai:doaj.org-article:c4027c33e642456ca4ee7e8415ec09522021-12-02T17:51:21ZPotential adverse drug events and its predictors among hospitalized patients at medical center in Ethiopia: a prospective observational study10.1038/s41598-021-91281-52045-2322https://doaj.org/article/c4027c33e642456ca4ee7e8415ec09522021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91281-5https://doaj.org/toc/2045-2322Abstract Potential adverse drug event (PADE) is a medication error with the potential to cause associate degree injury however that does not cause any injury, either due to specific circumstances, chance, or as a result of the error being intercepted and corrected. This study aimed to assess the incidence, contributing factors, predictors, severity, and preventability of PADEs among hospitalized adult patients at Jimma Medical Center. A prospective observational study was conducted among hospitalized adult patients at a tertiary hospital in Ethiopia. Logistic regression was performed to identify factors predicting PADE occurrence. P-value < 0.05 was considered for statistical significance. A total of 319 patients were included. About 50.5% of them were females. The mean ± SD age of the participants was 43 ± 17.6 years. Ninety-four PADEs were identified. Number of medications (adjusted OR = 5.12; 95% CI: 2.01–13.05; p = 0.001), anticoagulants (adjusted OR = 2.51; 95% CI: 1.22–5.19; p = 0.013), anti-seizures (adjusted OR = 21.96; 95% CI: 6.57–73.39; p < 0.0001), anti-tuberculosis (adjusted OR = 2.2; 95% CI: 1.002–4.59, p = 0.049), and Elixhauser comorbidity Index ≤ 15 (adjusted OR = 6.24; 95% CI: 1.48–26.25, p = 0.013) were independent predictors of PADEs occurrence. About one-third of patients admitted to the hospital experienced PADEs.Tamiru SahiluMestawet GetachewTsegaye MelakuTadesse ShelemeDuresa AbuTesfu ZewduNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tamiru Sahilu Mestawet Getachew Tsegaye Melaku Tadesse Sheleme Duresa Abu Tesfu Zewdu Potential adverse drug events and its predictors among hospitalized patients at medical center in Ethiopia: a prospective observational study
description	Abstract Potential adverse drug event (PADE) is a medication error with the potential to cause associate degree injury however that does not cause any injury, either due to specific circumstances, chance, or as a result of the error being intercepted and corrected. This study aimed to assess the incidence, contributing factors, predictors, severity, and preventability of PADEs among hospitalized adult patients at Jimma Medical Center. A prospective observational study was conducted among hospitalized adult patients at a tertiary hospital in Ethiopia. Logistic regression was performed to identify factors predicting PADE occurrence. P-value < 0.05 was considered for statistical significance. A total of 319 patients were included. About 50.5% of them were females. The mean ± SD age of the participants was 43 ± 17.6 years. Ninety-four PADEs were identified. Number of medications (adjusted OR = 5.12; 95% CI: 2.01–13.05; p = 0.001), anticoagulants (adjusted OR = 2.51; 95% CI: 1.22–5.19; p = 0.013), anti-seizures (adjusted OR = 21.96; 95% CI: 6.57–73.39; p < 0.0001), anti-tuberculosis (adjusted OR = 2.2; 95% CI: 1.002–4.59, p = 0.049), and Elixhauser comorbidity Index ≤ 15 (adjusted OR = 6.24; 95% CI: 1.48–26.25, p = 0.013) were independent predictors of PADEs occurrence. About one-third of patients admitted to the hospital experienced PADEs.
format	article
author	Tamiru Sahilu Mestawet Getachew Tsegaye Melaku Tadesse Sheleme Duresa Abu Tesfu Zewdu
author_facet	Tamiru Sahilu Mestawet Getachew Tsegaye Melaku Tadesse Sheleme Duresa Abu Tesfu Zewdu
author_sort	Tamiru Sahilu
title	Potential adverse drug events and its predictors among hospitalized patients at medical center in Ethiopia: a prospective observational study
title_short	Potential adverse drug events and its predictors among hospitalized patients at medical center in Ethiopia: a prospective observational study
title_full	Potential adverse drug events and its predictors among hospitalized patients at medical center in Ethiopia: a prospective observational study
title_fullStr	Potential adverse drug events and its predictors among hospitalized patients at medical center in Ethiopia: a prospective observational study
title_full_unstemmed	Potential adverse drug events and its predictors among hospitalized patients at medical center in Ethiopia: a prospective observational study
title_sort	potential adverse drug events and its predictors among hospitalized patients at medical center in ethiopia: a prospective observational study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4027c33e642456ca4ee7e8415ec0952
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Potential adverse drug events and its predictors among hospitalized patients at medical center in Ethiopia: a prospective observational study

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