Association study between COMT, DRD2, and DRD3 gene variants and antipsychotic treatment response in Mexican patients with schizophrenia
Raul Escamilla,1 Beatriz Camarena,2 Ricardo Saracco-Alvarez,1 Ana Fresán,3 Sandra Hernández,2 Alejandro Aguilar-García2 1Schizophrenia Clinic, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (INPRFM), Mexico City, Mexico;...
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2018
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oai:doaj.org-article:c40327e30f7146f1a046ee6703b571452021-12-02T02:59:20ZAssociation study between COMT, DRD2, and DRD3 gene variants and antipsychotic treatment response in Mexican patients with schizophrenia1178-2021https://doaj.org/article/c40327e30f7146f1a046ee6703b571452018-11-01T00:00:00Zhttps://www.dovepress.com/association-study-between-comt-drd2-and-drd3-gene-variants-and-antipsy-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Raul Escamilla,1 Beatriz Camarena,2 Ricardo Saracco-Alvarez,1 Ana Fresán,3 Sandra Hernández,2 Alejandro Aguilar-García2 1Schizophrenia Clinic, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (INPRFM), Mexico City, Mexico; 2Department of Pharmacogenetics, INPRFM, Mexico City, Mexico; 3Division of Clinical Research, INPRFM, Mexico City, Mexico Purpose: The efficacy of schizophrenia treatments using antipsychotics (APs) has long been established, but the benefit obtained by several patients using conventional APs (typical or atypical) has not been enough. Currently, the genetic study of the primary mechanisms of action of the APs has been focused on the dopaminergic pathways. The objective of this study was to determine if the response phenotypes (responder, resistance to treatment, and ultra-resistance to treatment groups) are associated with six single-nucleotide polymorphisms: COMT (Val158Met), DRD2 (A-241G, C376G, C939T, Taq1A), and DRD3 (Ser9Gly).Patients and methods: We classified the patients through a retrospective/prospective methodology to define response phenotypes.Results: COMT/Val158Met and DRD3/Ser9Gly were associated with the responder group (P<0.05). The single-nucleotide polymorphism A-241G of DRD2 gene was related with the resistant-to-treatment group (P<0.001). Finally, Met/Met of COMT and Ser/Gly of DRD3 genes showed a predictive effect associated with the resistant-to-treatment phenotype.Conclusion: Further analyses should be performed to validate these genetic markers as mediators for the response to APs. Keywords: pharmacogenetics, dopamine, resistant to treatment, ultraresistant to treatmentEscamilla RCamarena BSaracco-Alvarez RFresán AHernández SAguilar-García ADove Medical PressarticlePharmacogeneticsdopamineresistant to treatmentultra-resistant to treatment.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2981-2987 (2018) |
| institution |
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DOAJ |
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Pharmacogenetics dopamine resistant to treatment ultra-resistant to treatment. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Pharmacogenetics dopamine resistant to treatment ultra-resistant to treatment. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Escamilla R Camarena B Saracco-Alvarez R Fresán A Hernández S Aguilar-García A Association study between COMT, DRD2, and DRD3 gene variants and antipsychotic treatment response in Mexican patients with schizophrenia |
| description |
Raul Escamilla,1 Beatriz Camarena,2 Ricardo Saracco-Alvarez,1 Ana Fresán,3 Sandra Hernández,2 Alejandro Aguilar-García2 1Schizophrenia Clinic, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (INPRFM), Mexico City, Mexico; 2Department of Pharmacogenetics, INPRFM, Mexico City, Mexico; 3Division of Clinical Research, INPRFM, Mexico City, Mexico Purpose: The efficacy of schizophrenia treatments using antipsychotics (APs) has long been established, but the benefit obtained by several patients using conventional APs (typical or atypical) has not been enough. Currently, the genetic study of the primary mechanisms of action of the APs has been focused on the dopaminergic pathways. The objective of this study was to determine if the response phenotypes (responder, resistance to treatment, and ultra-resistance to treatment groups) are associated with six single-nucleotide polymorphisms: COMT (Val158Met), DRD2 (A-241G, C376G, C939T, Taq1A), and DRD3 (Ser9Gly).Patients and methods: We classified the patients through a retrospective/prospective methodology to define response phenotypes.Results: COMT/Val158Met and DRD3/Ser9Gly were associated with the responder group (P<0.05). The single-nucleotide polymorphism A-241G of DRD2 gene was related with the resistant-to-treatment group (P<0.001). Finally, Met/Met of COMT and Ser/Gly of DRD3 genes showed a predictive effect associated with the resistant-to-treatment phenotype.Conclusion: Further analyses should be performed to validate these genetic markers as mediators for the response to APs. Keywords: pharmacogenetics, dopamine, resistant to treatment, ultraresistant to treatment |
| format |
article |
| author |
Escamilla R Camarena B Saracco-Alvarez R Fresán A Hernández S Aguilar-García A |
| author_facet |
Escamilla R Camarena B Saracco-Alvarez R Fresán A Hernández S Aguilar-García A |
| author_sort |
Escamilla R |
| title |
Association study between COMT, DRD2, and DRD3 gene variants and antipsychotic treatment response in Mexican patients with schizophrenia |
| title_short |
Association study between COMT, DRD2, and DRD3 gene variants and antipsychotic treatment response in Mexican patients with schizophrenia |
| title_full |
Association study between COMT, DRD2, and DRD3 gene variants and antipsychotic treatment response in Mexican patients with schizophrenia |
| title_fullStr |
Association study between COMT, DRD2, and DRD3 gene variants and antipsychotic treatment response in Mexican patients with schizophrenia |
| title_full_unstemmed |
Association study between COMT, DRD2, and DRD3 gene variants and antipsychotic treatment response in Mexican patients with schizophrenia |
| title_sort |
association study between comt, drd2, and drd3 gene variants and antipsychotic treatment response in mexican patients with schizophrenia |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/c40327e30f7146f1a046ee6703b57145 |
| work_keys_str_mv |
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