Comparison of prognostic genomic predictors in colorectal cancer.
<h4>Background</h4>Although several prognostic genomic predictors have been identified from independent studies, it remains unclear whether these predictors are actually concordant with respect to their predictions for individual patients and which predictor performs best. We compared fi...
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oai:doaj.org-article:c40504f2b47848449d4f2efcb243ecfc2021-11-18T07:48:29ZComparison of prognostic genomic predictors in colorectal cancer.1932-620310.1371/journal.pone.0060778https://doaj.org/article/c40504f2b47848449d4f2efcb243ecfc2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23626670/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Although several prognostic genomic predictors have been identified from independent studies, it remains unclear whether these predictors are actually concordant with respect to their predictions for individual patients and which predictor performs best. We compared five prognostic genomic predictors, the V7RHS, the ColoGuideEx, the Meta163, the OncoDX, and the MDA114, in terms of predicting disease-free survival in two independent cohorts of patients with colorectal cancer.<h4>Study design</h4>Using original classification algorithms, we tested the predictions of five genomic predictors for disease-free survival in two cohorts of patients with colorectal cancer (n = 229 and n = 168) and evaluated concordance of predictors in predicting outcomes for individual patients.<h4>Results</h4>We found that only two predictors, OncoDX and MDA114, demonstrated robust performance in identifying patients with poor prognosis in 2 independent cohorts. These two predictors also had modest but significant concordance of predicted outcome (r>0.3, P<0.001 in both cohorts).<h4>Conclusions</h4>Further validation of developed genomic predictors is necessary. Despite the limited number of genes shared by OncoDX and MDA114, individual-patient outcomes predicted by these two predictors were significantly concordant.Yun-Yong ParkSung Sook LeeJae Yun LimSang Cheol KimSang Bae KimBo Hwa SohnIn-Sun ChuSang Cheul OhEun Sung ParkWoojin JeongSung Soo KimScott KopetzJu-Seog LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e60778 (2013) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
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Medicine R Science Q Yun-Yong Park Sung Sook Lee Jae Yun Lim Sang Cheol Kim Sang Bae Kim Bo Hwa Sohn In-Sun Chu Sang Cheul Oh Eun Sung Park Woojin Jeong Sung Soo Kim Scott Kopetz Ju-Seog Lee Comparison of prognostic genomic predictors in colorectal cancer. |
| description |
<h4>Background</h4>Although several prognostic genomic predictors have been identified from independent studies, it remains unclear whether these predictors are actually concordant with respect to their predictions for individual patients and which predictor performs best. We compared five prognostic genomic predictors, the V7RHS, the ColoGuideEx, the Meta163, the OncoDX, and the MDA114, in terms of predicting disease-free survival in two independent cohorts of patients with colorectal cancer.<h4>Study design</h4>Using original classification algorithms, we tested the predictions of five genomic predictors for disease-free survival in two cohorts of patients with colorectal cancer (n = 229 and n = 168) and evaluated concordance of predictors in predicting outcomes for individual patients.<h4>Results</h4>We found that only two predictors, OncoDX and MDA114, demonstrated robust performance in identifying patients with poor prognosis in 2 independent cohorts. These two predictors also had modest but significant concordance of predicted outcome (r>0.3, P<0.001 in both cohorts).<h4>Conclusions</h4>Further validation of developed genomic predictors is necessary. Despite the limited number of genes shared by OncoDX and MDA114, individual-patient outcomes predicted by these two predictors were significantly concordant. |
| format |
article |
| author |
Yun-Yong Park Sung Sook Lee Jae Yun Lim Sang Cheol Kim Sang Bae Kim Bo Hwa Sohn In-Sun Chu Sang Cheul Oh Eun Sung Park Woojin Jeong Sung Soo Kim Scott Kopetz Ju-Seog Lee |
| author_facet |
Yun-Yong Park Sung Sook Lee Jae Yun Lim Sang Cheol Kim Sang Bae Kim Bo Hwa Sohn In-Sun Chu Sang Cheul Oh Eun Sung Park Woojin Jeong Sung Soo Kim Scott Kopetz Ju-Seog Lee |
| author_sort |
Yun-Yong Park |
| title |
Comparison of prognostic genomic predictors in colorectal cancer. |
| title_short |
Comparison of prognostic genomic predictors in colorectal cancer. |
| title_full |
Comparison of prognostic genomic predictors in colorectal cancer. |
| title_fullStr |
Comparison of prognostic genomic predictors in colorectal cancer. |
| title_full_unstemmed |
Comparison of prognostic genomic predictors in colorectal cancer. |
| title_sort |
comparison of prognostic genomic predictors in colorectal cancer. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/c40504f2b47848449d4f2efcb243ecfc |
| work_keys_str_mv |
AT yunyongpark comparisonofprognosticgenomicpredictorsincolorectalcancer AT sungsooklee comparisonofprognosticgenomicpredictorsincolorectalcancer AT jaeyunlim comparisonofprognosticgenomicpredictorsincolorectalcancer AT sangcheolkim comparisonofprognosticgenomicpredictorsincolorectalcancer AT sangbaekim comparisonofprognosticgenomicpredictorsincolorectalcancer AT bohwasohn comparisonofprognosticgenomicpredictorsincolorectalcancer AT insunchu comparisonofprognosticgenomicpredictorsincolorectalcancer AT sangcheuloh comparisonofprognosticgenomicpredictorsincolorectalcancer AT eunsungpark comparisonofprognosticgenomicpredictorsincolorectalcancer AT woojinjeong comparisonofprognosticgenomicpredictorsincolorectalcancer AT sungsookim comparisonofprognosticgenomicpredictorsincolorectalcancer AT scottkopetz comparisonofprognosticgenomicpredictorsincolorectalcancer AT juseoglee comparisonofprognosticgenomicpredictorsincolorectalcancer |
| _version_ |
1718422935533780992 |