Impact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review

BackgroundIt is critical to develop a reliable and cost-effective prognostic tool for colorectal cancer (CRC) stratification and treatment optimization. Tumor–stroma ratio (TSR) may be a promising indicator of poor prognosis in CRC patients. As a result, we conducted a systematic review on the predi...

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Autores principales:	Jinlai Gao, Zhangguo Shen, Zaixing Deng, Lina Mei
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tumor–stroma ratio colorectal cancer meta-analysis stroma content prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c4053897b2134acf916e0f8874c0b5d6
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spelling	oai:doaj.org-article:c4053897b2134acf916e0f8874c0b5d62021-11-16T07:19:08ZImpact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review2234-943X10.3389/fonc.2021.738080https://doaj.org/article/c4053897b2134acf916e0f8874c0b5d62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.738080/fullhttps://doaj.org/toc/2234-943XBackgroundIt is critical to develop a reliable and cost-effective prognostic tool for colorectal cancer (CRC) stratification and treatment optimization. Tumor–stroma ratio (TSR) may be a promising indicator of poor prognosis in CRC patients. As a result, we conducted a systematic review on the predictive value of TSR in CRC.MethodsThis study was carried out according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guideline. An electronic search was completed using commonly used databases PubMed, CENTRAL, Cochrane Central Register of Controlled Trials, and Google scholar till the last search up to May 30, 2021. STATA version 13 was used to analyze the data.ResultsA total of 13 studies [(12 for disease-free survival (DFS) and nine studies for overall survival (OS)] involving 4,857 patients met the inclusion criteria for the systematic review in the present study. In individuals with stage II CRC, stage III CRC, or mixed stage CRC, we observed a significantly higher pooled hazard ratio (HR) in those with a low TSR/greater stromal content (HR, 1.54; 95% CI: 1.20 to 1.88), (HR, 1.90; 95% CI: 1.35 to 2.45), and (HR, 1.70; 95% CI: 1.45 to 1.95), respectively, for predicting DFS. We found that a low TSR ratio had a statistically significant predictive relevance for stage II (HR, 1.43; 95% CI: 1.09 to 1.77) and mixed stages of CRC (HR, 1.65; 95% CI: 1.31 to 2.0) for outcome OS.ConclusionIn patients with CRC, low TSR was found to be a prognostic factor for a worse prognosis (DFS and OS).Jinlai GaoZhangguo ShenZaixing DengLina MeiFrontiers Media S.A.articletumor–stroma ratiocolorectal cancermeta-analysisstroma contentprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor–stroma ratio colorectal cancer meta-analysis stroma content prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	tumor–stroma ratio colorectal cancer meta-analysis stroma content prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jinlai Gao Zhangguo Shen Zaixing Deng Lina Mei Impact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review
description	BackgroundIt is critical to develop a reliable and cost-effective prognostic tool for colorectal cancer (CRC) stratification and treatment optimization. Tumor–stroma ratio (TSR) may be a promising indicator of poor prognosis in CRC patients. As a result, we conducted a systematic review on the predictive value of TSR in CRC.MethodsThis study was carried out according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guideline. An electronic search was completed using commonly used databases PubMed, CENTRAL, Cochrane Central Register of Controlled Trials, and Google scholar till the last search up to May 30, 2021. STATA version 13 was used to analyze the data.ResultsA total of 13 studies [(12 for disease-free survival (DFS) and nine studies for overall survival (OS)] involving 4,857 patients met the inclusion criteria for the systematic review in the present study. In individuals with stage II CRC, stage III CRC, or mixed stage CRC, we observed a significantly higher pooled hazard ratio (HR) in those with a low TSR/greater stromal content (HR, 1.54; 95% CI: 1.20 to 1.88), (HR, 1.90; 95% CI: 1.35 to 2.45), and (HR, 1.70; 95% CI: 1.45 to 1.95), respectively, for predicting DFS. We found that a low TSR ratio had a statistically significant predictive relevance for stage II (HR, 1.43; 95% CI: 1.09 to 1.77) and mixed stages of CRC (HR, 1.65; 95% CI: 1.31 to 2.0) for outcome OS.ConclusionIn patients with CRC, low TSR was found to be a prognostic factor for a worse prognosis (DFS and OS).
format	article
author	Jinlai Gao Zhangguo Shen Zaixing Deng Lina Mei
author_facet	Jinlai Gao Zhangguo Shen Zaixing Deng Lina Mei
author_sort	Jinlai Gao
title	Impact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review
title_short	Impact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review
title_full	Impact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review
title_fullStr	Impact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review
title_full_unstemmed	Impact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review
title_sort	impact of tumor–stroma ratio on the prognosis of colorectal cancer: a systematic review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c4053897b2134acf916e0f8874c0b5d6
work_keys_str_mv	AT jinlaigao impactoftumorstromaratioontheprognosisofcolorectalcancerasystematicreview AT zhangguoshen impactoftumorstromaratioontheprognosisofcolorectalcancerasystematicreview AT zaixingdeng impactoftumorstromaratioontheprognosisofcolorectalcancerasystematicreview AT linamei impactoftumorstromaratioontheprognosisofcolorectalcancerasystematicreview
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Impact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review

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