The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis

Introduction Identifying target oncogenic alterations in lung cancer represents a major development in disease management. We examined the association of fibroblast growth factor receptor 1 (FGFR1) gene amplification with pathological characteristics and geographic region. Material and methods We c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jian-Long Miao, Jin-Hua Zhou, Jing-Jing Cai, Rui-Juan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	lung cancer fibroblast growth factor receptor 1 gene amplification Medicine R
Acceso en línea:	https://doaj.org/article/c40562fc219545e3a48d1209b6cabfc4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c40562fc219545e3a48d1209b6cabfc4
record_format	dspace
spelling	oai:doaj.org-article:c40562fc219545e3a48d1209b6cabfc42021-12-02T18:39:10ZThe association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis1734-19221896-915110.5114/aoms.2020.91284https://doaj.org/article/c40562fc219545e3a48d1209b6cabfc42019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/The-association-between-fibroblast-growth-factor-receptor-1-gene-amplification-and,74688,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Identifying target oncogenic alterations in lung cancer represents a major development in disease management. We examined the association of fibroblast growth factor receptor 1 (FGFR1) gene amplification with pathological characteristics and geographic region. Material and methods We conducted a meta-analysis of studies published between January 2010 and October 2016. Relative risks (RR) and corresponding 95% confidence intervals (CI) were calculated regarding the rate of FGFR1 amplification in different lung cancer types and geographic region. Results Twenty-three studies (5252 patients) were included. There was heterogeneity between studies. However, in subgroup analyses for squamous cell carcinoma (SCC), small cell lung cancer (SCLC), studies using the same definition of FGFR1 amplification, and those from Australia, no significant heterogeneity was detected. The prevalence of FGFR1 amplification in these studies ranged from 4.9% to 49.2% in non-small cell lung cancer (NSCLC), 5.1% to 41.5% in SCC, 0% to 14.7% in adenocarcinoma, and 0% to 7.8% in SCLC. The prevalence of FGFR1 amplification was significantly higher in SCC than in adenocarcinoma (RR = 5.2) and SCLC (RR = 4.2). The prevalence of FGFR1 amplification ranged from 5.6% to 22.2% in Europe, 4.1% to 18.2% in the United States, 7.8% to 49.2% in Asia, and 14.2% to 18.6% in Australia. The rate of FGFR1 amplification was higher in Asians than in non-Asians (RR = 1.9) in NSCLC. Conclusions These results suggest that FGFR1 amplification occurs more frequently in SCC and in Asians. FGFR1 amplification may be a potential new therapeutic target for specific patients and lung cancer subtypes.Jian-Long MiaoJin-Hua ZhouJing-Jing CaiRui-Juan LiuTermedia Publishing Housearticlelung cancerfibroblast growth factor receptor 1gene amplificationMedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 16-26 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung cancer fibroblast growth factor receptor 1 gene amplification Medicine R
spellingShingle	lung cancer fibroblast growth factor receptor 1 gene amplification Medicine R Jian-Long Miao Jin-Hua Zhou Jing-Jing Cai Rui-Juan Liu The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis
description	Introduction Identifying target oncogenic alterations in lung cancer represents a major development in disease management. We examined the association of fibroblast growth factor receptor 1 (FGFR1) gene amplification with pathological characteristics and geographic region. Material and methods We conducted a meta-analysis of studies published between January 2010 and October 2016. Relative risks (RR) and corresponding 95% confidence intervals (CI) were calculated regarding the rate of FGFR1 amplification in different lung cancer types and geographic region. Results Twenty-three studies (5252 patients) were included. There was heterogeneity between studies. However, in subgroup analyses for squamous cell carcinoma (SCC), small cell lung cancer (SCLC), studies using the same definition of FGFR1 amplification, and those from Australia, no significant heterogeneity was detected. The prevalence of FGFR1 amplification in these studies ranged from 4.9% to 49.2% in non-small cell lung cancer (NSCLC), 5.1% to 41.5% in SCC, 0% to 14.7% in adenocarcinoma, and 0% to 7.8% in SCLC. The prevalence of FGFR1 amplification was significantly higher in SCC than in adenocarcinoma (RR = 5.2) and SCLC (RR = 4.2). The prevalence of FGFR1 amplification ranged from 5.6% to 22.2% in Europe, 4.1% to 18.2% in the United States, 7.8% to 49.2% in Asia, and 14.2% to 18.6% in Australia. The rate of FGFR1 amplification was higher in Asians than in non-Asians (RR = 1.9) in NSCLC. Conclusions These results suggest that FGFR1 amplification occurs more frequently in SCC and in Asians. FGFR1 amplification may be a potential new therapeutic target for specific patients and lung cancer subtypes.
format	article
author	Jian-Long Miao Jin-Hua Zhou Jing-Jing Cai Rui-Juan Liu
author_facet	Jian-Long Miao Jin-Hua Zhou Jing-Jing Cai Rui-Juan Liu
author_sort	Jian-Long Miao
title	The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis
title_short	The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis
title_full	The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis
title_fullStr	The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis
title_full_unstemmed	The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis
title_sort	association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/c40562fc219545e3a48d1209b6cabfc4
work_keys_str_mv	AT jianlongmiao theassociationbetweenfibroblastgrowthfactorreceptor1geneamplificationandlungcancerametaanalysis AT jinhuazhou theassociationbetweenfibroblastgrowthfactorreceptor1geneamplificationandlungcancerametaanalysis AT jingjingcai theassociationbetweenfibroblastgrowthfactorreceptor1geneamplificationandlungcancerametaanalysis AT ruijuanliu theassociationbetweenfibroblastgrowthfactorreceptor1geneamplificationandlungcancerametaanalysis AT jianlongmiao associationbetweenfibroblastgrowthfactorreceptor1geneamplificationandlungcancerametaanalysis AT jinhuazhou associationbetweenfibroblastgrowthfactorreceptor1geneamplificationandlungcancerametaanalysis AT jingjingcai associationbetweenfibroblastgrowthfactorreceptor1geneamplificationandlungcancerametaanalysis AT ruijuanliu associationbetweenfibroblastgrowthfactorreceptor1geneamplificationandlungcancerametaanalysis
_version_	1718377765242142720

The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis

Ejemplares similares