Predictors for one-year outcomes of cardiorespiratory fitness and cardiovascular risk factor control after cardiac rehabilitation in elderly patients: The EU-CaRE study.

<h4>Introduction</h4>Studies on effectiveness of cardiac rehabilitation (CR) in elderly cardiovascular disease patients are rare, and it is unknown, which patients benefit most. We aimed to identify predictors for 1-year outcomes of cardiorespiratory fitness and CV risk factor (CVRF) con...

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Autores principales:	Prisca Eser, Thimo Marcin, Eva Prescott, Leonie F Prins, Evelien Kolkman, Wendy Bruins, Astrid E van der Velde, Carlos Peña Gil, Marie-Christine Iliou, Diego Ardissino, Uwe Zeymer, Esther P Meindersma, Arnoud W J Van'tHof, Ed P de Kluiver, Matthias Wilhelm
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c406017a8e0a4548a1a7b576051921f9
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spelling	oai:doaj.org-article:c406017a8e0a4548a1a7b576051921f92021-12-02T20:18:41ZPredictors for one-year outcomes of cardiorespiratory fitness and cardiovascular risk factor control after cardiac rehabilitation in elderly patients: The EU-CaRE study.1932-620310.1371/journal.pone.0255472https://doaj.org/article/c406017a8e0a4548a1a7b576051921f92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255472https://doaj.org/toc/1932-6203<h4>Introduction</h4>Studies on effectiveness of cardiac rehabilitation (CR) in elderly cardiovascular disease patients are rare, and it is unknown, which patients benefit most. We aimed to identify predictors for 1-year outcomes of cardiorespiratory fitness and CV risk factor (CVRF) control in patients after completing CR programs offered across seven European countries.<h4>Methods</h4>Cardiovascular disease patients with minimal age 65 years who participated in comprehensive CR were included in this observational study. Peak oxygen uptake (VO2), body mass index (BMI), resting systolic blood pressure (BPsys), and low-density lipoprotein-cholesterol (LDL-C) were assessed before CR (T0), at termination of CR (T1), and 12 months after start of CR (T2). Predictors for changes were identified by multivariate regression models.<h4>Results</h4>Data was available from 1241 out of 1633 EU-CaRE patients. The strongest predictor for improvement in peak VO2 was open chest surgery, with a nearly four-fold increase in surgery compared to non-surgery patients. In patients after surgery, age, female sex, physical inactivity and time from index event to T0 were negative predictors for improvement in peak VO2. In patients without surgery, previous acute coronary syndrome and higher exercise capacity at T0 were the only negative predictors. Neither number of attended training sessions nor duration of CR were significantly associated with change in peak VO2. Non-surgery patients were more likely to achieve risk factor targets (BPsys, LDL-C, BMI) than surgery patients.<h4>Conclusions</h4>In a previously understudied population of elderly CR patients, time between index event and start of CR in surgery and disease severity in non-surgery patients were the most important predictors for long-term improvement of peak VO2. Non-surgery patients had better CVRF control.Prisca EserThimo MarcinEva PrescottLeonie F PrinsEvelien KolkmanWendy BruinsAstrid E van der VeldeCarlos Peña GilMarie-Christine IliouDiego ArdissinoUwe ZeymerEsther P MeindersmaArnoud W J Van'tHofEd P de KluiverMatthias WilhelmPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255472 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Prisca Eser Thimo Marcin Eva Prescott Leonie F Prins Evelien Kolkman Wendy Bruins Astrid E van der Velde Carlos Peña Gil Marie-Christine Iliou Diego Ardissino Uwe Zeymer Esther P Meindersma Arnoud W J Van'tHof Ed P de Kluiver Matthias Wilhelm Predictors for one-year outcomes of cardiorespiratory fitness and cardiovascular risk factor control after cardiac rehabilitation in elderly patients: The EU-CaRE study.
description	<h4>Introduction</h4>Studies on effectiveness of cardiac rehabilitation (CR) in elderly cardiovascular disease patients are rare, and it is unknown, which patients benefit most. We aimed to identify predictors for 1-year outcomes of cardiorespiratory fitness and CV risk factor (CVRF) control in patients after completing CR programs offered across seven European countries.<h4>Methods</h4>Cardiovascular disease patients with minimal age 65 years who participated in comprehensive CR were included in this observational study. Peak oxygen uptake (VO2), body mass index (BMI), resting systolic blood pressure (BPsys), and low-density lipoprotein-cholesterol (LDL-C) were assessed before CR (T0), at termination of CR (T1), and 12 months after start of CR (T2). Predictors for changes were identified by multivariate regression models.<h4>Results</h4>Data was available from 1241 out of 1633 EU-CaRE patients. The strongest predictor for improvement in peak VO2 was open chest surgery, with a nearly four-fold increase in surgery compared to non-surgery patients. In patients after surgery, age, female sex, physical inactivity and time from index event to T0 were negative predictors for improvement in peak VO2. In patients without surgery, previous acute coronary syndrome and higher exercise capacity at T0 were the only negative predictors. Neither number of attended training sessions nor duration of CR were significantly associated with change in peak VO2. Non-surgery patients were more likely to achieve risk factor targets (BPsys, LDL-C, BMI) than surgery patients.<h4>Conclusions</h4>In a previously understudied population of elderly CR patients, time between index event and start of CR in surgery and disease severity in non-surgery patients were the most important predictors for long-term improvement of peak VO2. Non-surgery patients had better CVRF control.
format	article
author	Prisca Eser Thimo Marcin Eva Prescott Leonie F Prins Evelien Kolkman Wendy Bruins Astrid E van der Velde Carlos Peña Gil Marie-Christine Iliou Diego Ardissino Uwe Zeymer Esther P Meindersma Arnoud W J Van'tHof Ed P de Kluiver Matthias Wilhelm
author_facet	Prisca Eser Thimo Marcin Eva Prescott Leonie F Prins Evelien Kolkman Wendy Bruins Astrid E van der Velde Carlos Peña Gil Marie-Christine Iliou Diego Ardissino Uwe Zeymer Esther P Meindersma Arnoud W J Van'tHof Ed P de Kluiver Matthias Wilhelm
author_sort	Prisca Eser
title	Predictors for one-year outcomes of cardiorespiratory fitness and cardiovascular risk factor control after cardiac rehabilitation in elderly patients: The EU-CaRE study.
title_short	Predictors for one-year outcomes of cardiorespiratory fitness and cardiovascular risk factor control after cardiac rehabilitation in elderly patients: The EU-CaRE study.
title_full	Predictors for one-year outcomes of cardiorespiratory fitness and cardiovascular risk factor control after cardiac rehabilitation in elderly patients: The EU-CaRE study.
title_fullStr	Predictors for one-year outcomes of cardiorespiratory fitness and cardiovascular risk factor control after cardiac rehabilitation in elderly patients: The EU-CaRE study.
title_full_unstemmed	Predictors for one-year outcomes of cardiorespiratory fitness and cardiovascular risk factor control after cardiac rehabilitation in elderly patients: The EU-CaRE study.
title_sort	predictors for one-year outcomes of cardiorespiratory fitness and cardiovascular risk factor control after cardiac rehabilitation in elderly patients: the eu-care study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c406017a8e0a4548a1a7b576051921f9
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Predictors for one-year outcomes of cardiorespiratory fitness and cardiovascular risk factor control after cardiac rehabilitation in elderly patients: The EU-CaRE study.

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