Effect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participants

Marion L Vetter1,2,3, Alisha Wade1, Leslie G Womble3, Cornelia Dalton-Bakes1, Thomas A Wadden3, Nayyar Iqbal1,21Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; 2Division of Endocrinology, Department of Me...

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Autores principales:	Vetter M, Wade A, Womble L, Dalton-Bakes C, Wadden T, Iqbal N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	macronutrient composition adipokines Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c407f86586d944d9b5484224d13a29db
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spelling	oai:doaj.org-article:c407f86586d944d9b5484224d13a29db2021-12-02T06:18:32ZEffect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participants1178-7007https://doaj.org/article/c407f86586d944d9b5484224d13a29db2010-10-01T00:00:00Zhttps://www.dovepress.com/effect-of-a-low-carbohydrate-diet-versus-a-low-fat-calorie-restricted--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Marion L Vetter1,2,3, Alisha Wade1, Leslie G Womble3, Cornelia Dalton-Bakes1, Thomas A Wadden3, Nayyar Iqbal1,21Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; 2Division of Endocrinology, Department of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA; 3Department of Psychiatry, Center for Weight and Eating Disorders, University of Pennsylvania School of Medicine, Philadelphia, PA, USAAbstract: The effect of dietary macronutrient composition on adipokine concentrations remains unclear. Greater reductions in leptin have been reported in participants who followed low-carbohydrate versus low-fat diets, although these studies did not adjust for the important effects of weight loss on adipokines. We investigated the effect of macronutrient composition on adipokine levels in 144 obese, diabetic participants who were randomly assigned to a low-carbohydrate (<30 g/day) or low-fat diet (≤30% of calories from fat with a deficit of 500 kcal/day). Weight, adipokines, and dietary intake were assessed at baseline and 6 months. Complete data were available for 79 participants. At month 6, weight, leptin, adiponectin, and tumor necrosis factor-a concentrations did not differ significantly between groups (P > 0.05 for all variables). However, significant changes in leptin and adiponectin occurred over time (P < 0.001 and P < 0.012, respectively). Modest weight loss, rather than macronutrient composition, likely accounted for the favorable changes observed in leptin and adiponectin over time.Keywords: diet, adipokine, obesity, diabetes, carbohydrate, hormoneVetter MVetter MWade AWomble LDalton-Bakes CWadden TIqbal NDove Medical Pressarticlemacronutrient composition adipokinesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 3, Pp 357-361 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	macronutrient composition adipokines Specialties of internal medicine RC581-951
spellingShingle	macronutrient composition adipokines Specialties of internal medicine RC581-951 Vetter M Vetter M Wade A Womble L Dalton-Bakes C Wadden T Iqbal N Effect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participants
description	Marion L Vetter1,2,3, Alisha Wade1, Leslie G Womble3, Cornelia Dalton-Bakes1, Thomas A Wadden3, Nayyar Iqbal1,21Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; 2Division of Endocrinology, Department of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA; 3Department of Psychiatry, Center for Weight and Eating Disorders, University of Pennsylvania School of Medicine, Philadelphia, PA, USAAbstract: The effect of dietary macronutrient composition on adipokine concentrations remains unclear. Greater reductions in leptin have been reported in participants who followed low-carbohydrate versus low-fat diets, although these studies did not adjust for the important effects of weight loss on adipokines. We investigated the effect of macronutrient composition on adipokine levels in 144 obese, diabetic participants who were randomly assigned to a low-carbohydrate (<30 g/day) or low-fat diet (≤30% of calories from fat with a deficit of 500 kcal/day). Weight, adipokines, and dietary intake were assessed at baseline and 6 months. Complete data were available for 79 participants. At month 6, weight, leptin, adiponectin, and tumor necrosis factor-a concentrations did not differ significantly between groups (P > 0.05 for all variables). However, significant changes in leptin and adiponectin occurred over time (P < 0.001 and P < 0.012, respectively). Modest weight loss, rather than macronutrient composition, likely accounted for the favorable changes observed in leptin and adiponectin over time.Keywords: diet, adipokine, obesity, diabetes, carbohydrate, hormone
format	article
author	Vetter M Vetter M Wade A Womble L Dalton-Bakes C Wadden T Iqbal N
author_facet	Vetter M Vetter M Wade A Womble L Dalton-Bakes C Wadden T Iqbal N
author_sort	Vetter M
title	Effect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participants
title_short	Effect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participants
title_full	Effect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participants
title_fullStr	Effect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participants
title_full_unstemmed	Effect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participants
title_sort	effect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participants
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/c407f86586d944d9b5484224d13a29db
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Effect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participants

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