Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla

Laminar fMRI based on BOLD and CBV contrast at ultrahigh magnetic fields has been applied for studying the dynamics of mesoscopic brain networks. However, the quantitative interpretations of BOLD/CBV fMRI results are confounded by different baseline physiology across cortical layers. Here we introdu...

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Autores principales:	Xingfeng Shao, Fanhua Guo, Qinyang Shou, Kai Wang, Kay Jann, Lirong Yan, Arthur W. Toga, Peng Zhang, Danny J.J. Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Laminar fMRI Perfusion Arterial spin labeling Neural circuit Visual spatial attention Ultrahigh field Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c40c6182f9394de4adbb14f6fceec57f
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spelling	oai:doaj.org-article:c40c6182f9394de4adbb14f6fceec57f2021-11-18T04:45:00ZLaminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla1095-957210.1016/j.neuroimage.2021.118724https://doaj.org/article/c40c6182f9394de4adbb14f6fceec57f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921009964https://doaj.org/toc/1095-9572Laminar fMRI based on BOLD and CBV contrast at ultrahigh magnetic fields has been applied for studying the dynamics of mesoscopic brain networks. However, the quantitative interpretations of BOLD/CBV fMRI results are confounded by different baseline physiology across cortical layers. Here we introduce a novel 3D zoomed pseudo-continuous arterial spin labeling (pCASL) technique at 7T that offers the capability for quantitative measurements of laminar cerebral blood flow (CBF) both at rest and during task activation with high spatial specificity and sensitivity. We found arterial transit time in superficial layers is ∼100 ms shorter than in middle/deep layers revealing the time course of labeled blood flowing from pial arteries to downstream microvasculature. Resting state CBF peaked in the middle layers which is highly consistent with microvascular density measured from human cortex specimens. Finger tapping induced a robust two-peak laminar profile of CBF increases in the superficial (somatosensory and premotor input) and deep (spinal output) layers of M1, while finger brushing task induced a weaker CBF increase in superficial layers (somatosensory input). This observation is highly consistent with reported laminar profiles of CBV activation on M1. We further demonstrated that visuospatial attention induced a predominant CBF increase in deep layers and a smaller CBF increase on top of the lower baseline CBF in superficial layers of V1 (feedback cortical input), while stimulus driven activity peaked in the middle layers (feedforward thalamic input). With the capability for quantitative CBF measurements both at baseline and during task activation, high-resolution ASL perfusion fMRI at 7T provides an important tool for in vivo assessment of neurovascular function and metabolic activities of neural circuits across cortical layers.Xingfeng ShaoFanhua GuoQinyang ShouKai WangKay JannLirong YanArthur W. TogaPeng ZhangDanny J.J. WangElsevierarticleLaminar fMRIPerfusionArterial spin labelingNeural circuitVisual spatial attentionUltrahigh fieldNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118724- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Laminar fMRI Perfusion Arterial spin labeling Neural circuit Visual spatial attention Ultrahigh field Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Laminar fMRI Perfusion Arterial spin labeling Neural circuit Visual spatial attention Ultrahigh field Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xingfeng Shao Fanhua Guo Qinyang Shou Kai Wang Kay Jann Lirong Yan Arthur W. Toga Peng Zhang Danny J.J. Wang Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla
description	Laminar fMRI based on BOLD and CBV contrast at ultrahigh magnetic fields has been applied for studying the dynamics of mesoscopic brain networks. However, the quantitative interpretations of BOLD/CBV fMRI results are confounded by different baseline physiology across cortical layers. Here we introduce a novel 3D zoomed pseudo-continuous arterial spin labeling (pCASL) technique at 7T that offers the capability for quantitative measurements of laminar cerebral blood flow (CBF) both at rest and during task activation with high spatial specificity and sensitivity. We found arterial transit time in superficial layers is ∼100 ms shorter than in middle/deep layers revealing the time course of labeled blood flowing from pial arteries to downstream microvasculature. Resting state CBF peaked in the middle layers which is highly consistent with microvascular density measured from human cortex specimens. Finger tapping induced a robust two-peak laminar profile of CBF increases in the superficial (somatosensory and premotor input) and deep (spinal output) layers of M1, while finger brushing task induced a weaker CBF increase in superficial layers (somatosensory input). This observation is highly consistent with reported laminar profiles of CBV activation on M1. We further demonstrated that visuospatial attention induced a predominant CBF increase in deep layers and a smaller CBF increase on top of the lower baseline CBF in superficial layers of V1 (feedback cortical input), while stimulus driven activity peaked in the middle layers (feedforward thalamic input). With the capability for quantitative CBF measurements both at baseline and during task activation, high-resolution ASL perfusion fMRI at 7T provides an important tool for in vivo assessment of neurovascular function and metabolic activities of neural circuits across cortical layers.
format	article
author	Xingfeng Shao Fanhua Guo Qinyang Shou Kai Wang Kay Jann Lirong Yan Arthur W. Toga Peng Zhang Danny J.J. Wang
author_facet	Xingfeng Shao Fanhua Guo Qinyang Shou Kai Wang Kay Jann Lirong Yan Arthur W. Toga Peng Zhang Danny J.J. Wang
author_sort	Xingfeng Shao
title	Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla
title_short	Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla
title_full	Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla
title_fullStr	Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla
title_full_unstemmed	Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla
title_sort	laminar perfusion imaging with zoomed arterial spin labeling at 7 tesla
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c40c6182f9394de4adbb14f6fceec57f
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_version_	1718425065062662144

Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla

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