COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women

<h4>Objective</h4> To compare hospitalized reproductive age women with COVID-19 who were pregnant, puerperal, or neither one nor the other in terms of demographic and clinical characteristics and disease progression using Brazilian epidemiological data. <h4>Methods</h4> A ret...

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Autores principales:	Fabiano Elisei Serra, Rossana Pulcineli Vieira Francisco, Patricia de Rossi, Maria de Lourdes Brizot, Agatha Sacramento Rodrigues
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c40fade1143c454eb487399d61a1c209
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spelling	oai:doaj.org-article:c40fade1143c454eb487399d61a1c2092021-11-25T05:54:25ZCOVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women1932-6203https://doaj.org/article/c40fade1143c454eb487399d61a1c2092021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592461/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4> To compare hospitalized reproductive age women with COVID-19 who were pregnant, puerperal, or neither one nor the other in terms of demographic and clinical characteristics and disease progression using Brazilian epidemiological data. <h4>Methods</h4> A retrospective analysis of the records of the Information System of the Epidemiological Surveillance of Influenza of the Health Ministry of Brazil was performed. It included the data of female patients aged 10 to 49 years hospitalized because of severe COVID-19 disease (RT-PCR+ for SARS-CoV-2), from February 17, 2020 to January 02, 2021. They were separated into 3 groups: pregnant, puerperal, and neither pregnant nor puerperal. General comparisons and then adjustments for confounding variables (propensity score matching [PSM]) were made, using demographic and clinical characteristics, disease progression (admission to the intensive care unit [ICU] and invasive or noninvasive ventilatory support), and outcome (cure or death). Deaths were analyzed in each group according to comorbidities, invasive or noninvasive ventilatory support, and admission to the ICU. <h4>Results</h4> As many as 40,640 reproductive age women hospitalized for COVID-19 were identified: 3,372 were pregnant, 794 were puerperal, and 36,474 were neither pregnant nor puerperal. Groups were significantly different in terms of demographic data and comorbidities (p<0.0001). Pregnant and puerperal women were less likely to be symptomatic than the women who were neither one nor the other (72.1%, 69.7% and 88.8%, respectively). Pregnant women, however, had a higher frequency of anosmia, and ageusia than the others. After PSM, puerperal women had a worse prognosis than pregnant women with respect to admission to the ICU, invasive ventilatory support, and death, with OR (95% CI) 1.97 (1.55 – 2.50), 2.71 (1.78 – 4.13), and 2.51 (1.79 – 3.52), respectively. <h4>Conclusion</h4> Puerperal women were at a higher risk for serious outcomes (need for the ICU, need for invasive and noninvasive ventilatory support, and death) than pregnant women.Fabiano Elisei SerraRossana Pulcineli Vieira FranciscoPatricia de RossiMaria de Lourdes BrizotAgatha Sacramento RodriguesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabiano Elisei Serra Rossana Pulcineli Vieira Francisco Patricia de Rossi Maria de Lourdes Brizot Agatha Sacramento Rodrigues COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women
description	<h4>Objective</h4> To compare hospitalized reproductive age women with COVID-19 who were pregnant, puerperal, or neither one nor the other in terms of demographic and clinical characteristics and disease progression using Brazilian epidemiological data. <h4>Methods</h4> A retrospective analysis of the records of the Information System of the Epidemiological Surveillance of Influenza of the Health Ministry of Brazil was performed. It included the data of female patients aged 10 to 49 years hospitalized because of severe COVID-19 disease (RT-PCR+ for SARS-CoV-2), from February 17, 2020 to January 02, 2021. They were separated into 3 groups: pregnant, puerperal, and neither pregnant nor puerperal. General comparisons and then adjustments for confounding variables (propensity score matching [PSM]) were made, using demographic and clinical characteristics, disease progression (admission to the intensive care unit [ICU] and invasive or noninvasive ventilatory support), and outcome (cure or death). Deaths were analyzed in each group according to comorbidities, invasive or noninvasive ventilatory support, and admission to the ICU. <h4>Results</h4> As many as 40,640 reproductive age women hospitalized for COVID-19 were identified: 3,372 were pregnant, 794 were puerperal, and 36,474 were neither pregnant nor puerperal. Groups were significantly different in terms of demographic data and comorbidities (p<0.0001). Pregnant and puerperal women were less likely to be symptomatic than the women who were neither one nor the other (72.1%, 69.7% and 88.8%, respectively). Pregnant women, however, had a higher frequency of anosmia, and ageusia than the others. After PSM, puerperal women had a worse prognosis than pregnant women with respect to admission to the ICU, invasive ventilatory support, and death, with OR (95% CI) 1.97 (1.55 – 2.50), 2.71 (1.78 – 4.13), and 2.51 (1.79 – 3.52), respectively. <h4>Conclusion</h4> Puerperal women were at a higher risk for serious outcomes (need for the ICU, need for invasive and noninvasive ventilatory support, and death) than pregnant women.
format	article
author	Fabiano Elisei Serra Rossana Pulcineli Vieira Francisco Patricia de Rossi Maria de Lourdes Brizot Agatha Sacramento Rodrigues
author_facet	Fabiano Elisei Serra Rossana Pulcineli Vieira Francisco Patricia de Rossi Maria de Lourdes Brizot Agatha Sacramento Rodrigues
author_sort	Fabiano Elisei Serra
title	COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women
title_short	COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women
title_full	COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women
title_fullStr	COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women
title_full_unstemmed	COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women
title_sort	covid-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c40fade1143c454eb487399d61a1c209
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COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women

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