Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings

Abstract Magnesium-based implants (MBIs) have recently attracted great attention in bone regeneration due to elastic modulus similar to bone. Nevertheless, the degradation rate and hydrogen release of MBIs in the body have to be tackled for practical applications. In the present study, we present a...

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Autores principales:	Mohammad Amin Khalili, Elnaz Tamjid
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4104269e13744ff8469e8fc8c340c5d
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spelling	oai:doaj.org-article:c4104269e13744ff8469e8fc8c340c5d2021-12-02T16:45:14ZControlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings10.1038/s41598-021-87783-x2045-2322https://doaj.org/article/c4104269e13744ff8469e8fc8c340c5d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87783-xhttps://doaj.org/toc/2045-2322Abstract Magnesium-based implants (MBIs) have recently attracted great attention in bone regeneration due to elastic modulus similar to bone. Nevertheless, the degradation rate and hydrogen release of MBIs in the body have to be tackled for practical applications. In the present study, we present a metal–organic framework (MOF) nanoplates to reduce the degradation rate of AZ91 magnesium alloy. Zeolitic imidazolate frameworks (ZIF-8) with a specific surface area of 1789 m2 g−1 were prepared by solvothermal methods, and after dispersion in a chitosan solution (10% w/w), the suspension was electrospun on the surface of AZ91 alloy. Studying the degradation rate in simulated body fluid (SBF) by electrochemical analysis including potentiodynamic polarization and electrochemical impedance spectroscopy reveals that the degradation rate of the surface-modified implants decreases by ~ 80% as compared with the unmodified specimens. The reduced alkalization of the physiological environment and hydrogen release due to the implant degradation are shown. In vitro studies by fibroblasts and MG63 osteosarcoma cells exhibit improved cell adhesion and viability. The mechanisms behind the improved degradation resistance and enhanced bioactivity are presented and discussed. Surface modification of MBIs by MOF-chitosan coatings is a promising strategy to control the biodegradation of magnesium implants for bone regeneration.Mohammad Amin KhaliliElnaz TamjidNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad Amin Khalili Elnaz Tamjid Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings
description	Abstract Magnesium-based implants (MBIs) have recently attracted great attention in bone regeneration due to elastic modulus similar to bone. Nevertheless, the degradation rate and hydrogen release of MBIs in the body have to be tackled for practical applications. In the present study, we present a metal–organic framework (MOF) nanoplates to reduce the degradation rate of AZ91 magnesium alloy. Zeolitic imidazolate frameworks (ZIF-8) with a specific surface area of 1789 m2 g−1 were prepared by solvothermal methods, and after dispersion in a chitosan solution (10% w/w), the suspension was electrospun on the surface of AZ91 alloy. Studying the degradation rate in simulated body fluid (SBF) by electrochemical analysis including potentiodynamic polarization and electrochemical impedance spectroscopy reveals that the degradation rate of the surface-modified implants decreases by ~ 80% as compared with the unmodified specimens. The reduced alkalization of the physiological environment and hydrogen release due to the implant degradation are shown. In vitro studies by fibroblasts and MG63 osteosarcoma cells exhibit improved cell adhesion and viability. The mechanisms behind the improved degradation resistance and enhanced bioactivity are presented and discussed. Surface modification of MBIs by MOF-chitosan coatings is a promising strategy to control the biodegradation of magnesium implants for bone regeneration.
format	article
author	Mohammad Amin Khalili Elnaz Tamjid
author_facet	Mohammad Amin Khalili Elnaz Tamjid
author_sort	Mohammad Amin Khalili
title	Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings
title_short	Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings
title_full	Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings
title_fullStr	Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings
title_full_unstemmed	Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings
title_sort	controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4104269e13744ff8469e8fc8c340c5d
work_keys_str_mv	AT mohammadaminkhalili controlledbiodegradationofmagnesiumalloyinphysiologicalenvironmentbymetalorganicframeworknanocompositecoatings AT elnaztamjid controlledbiodegradationofmagnesiumalloyinphysiologicalenvironmentbymetalorganicframeworknanocompositecoatings
_version_	1718383479303962624

Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings

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