Psoriasis to Psoriatic Arthritis: The Application of Proteomics Technologies

Psoriatic disease (PsD) is a spectrum of diseases that affect both skin [cutaneous psoriasis (PsC)] and musculoskeletal features [psoriatic arthritis (PsA)]. A considerable number of patients with PsC have asymptomatic synovio-entheseal inflammations, and approximately one-third of those eventually...

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Autores principales:	Fei Qi, Yaqi Tan, Amin Yao, Xutong Yang, Yanling He
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	psoriasis psoriatic disease psoriatic arthritis proteomics biomarkers Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c4115c9fe8ba4b2c8c14efcad5deb5dd
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spelling	oai:doaj.org-article:c4115c9fe8ba4b2c8c14efcad5deb5dd2021-11-16T05:01:20ZPsoriasis to Psoriatic Arthritis: The Application of Proteomics Technologies2296-858X10.3389/fmed.2021.681172https://doaj.org/article/c4115c9fe8ba4b2c8c14efcad5deb5dd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.681172/fullhttps://doaj.org/toc/2296-858XPsoriatic disease (PsD) is a spectrum of diseases that affect both skin [cutaneous psoriasis (PsC)] and musculoskeletal features [psoriatic arthritis (PsA)]. A considerable number of patients with PsC have asymptomatic synovio-entheseal inflammations, and approximately one-third of those eventually progress to PsA with an enigmatic mechanism. Published studies have shown that early interventions to the very early-stage PsA would effectively prevent substantial bone destructions or deformities, suggesting an unmet goal for exploring early PsA biomarkers. The emergence of proteomics technologies brings a complete view of all involved proteins in PsA transitions, offers a unique chance to map all potential peptides, and allows a direct head-to-head comparison of interaction pathways in PsC and PsA. This review summarized the latest development of proteomics technologies, highlighted its application in PsA biomarker discovery, and discussed the possible clinical detectable PsA risk factors in patients with PsC.Fei QiYaqi TanAmin YaoXutong YangYanling HeFrontiers Media S.A.articlepsoriasispsoriatic diseasepsoriatic arthritisproteomicsbiomarkersMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis psoriatic disease psoriatic arthritis proteomics biomarkers Medicine (General) R5-920
spellingShingle	psoriasis psoriatic disease psoriatic arthritis proteomics biomarkers Medicine (General) R5-920 Fei Qi Yaqi Tan Amin Yao Xutong Yang Yanling He Psoriasis to Psoriatic Arthritis: The Application of Proteomics Technologies
description	Psoriatic disease (PsD) is a spectrum of diseases that affect both skin [cutaneous psoriasis (PsC)] and musculoskeletal features [psoriatic arthritis (PsA)]. A considerable number of patients with PsC have asymptomatic synovio-entheseal inflammations, and approximately one-third of those eventually progress to PsA with an enigmatic mechanism. Published studies have shown that early interventions to the very early-stage PsA would effectively prevent substantial bone destructions or deformities, suggesting an unmet goal for exploring early PsA biomarkers. The emergence of proteomics technologies brings a complete view of all involved proteins in PsA transitions, offers a unique chance to map all potential peptides, and allows a direct head-to-head comparison of interaction pathways in PsC and PsA. This review summarized the latest development of proteomics technologies, highlighted its application in PsA biomarker discovery, and discussed the possible clinical detectable PsA risk factors in patients with PsC.
format	article
author	Fei Qi Yaqi Tan Amin Yao Xutong Yang Yanling He
author_facet	Fei Qi Yaqi Tan Amin Yao Xutong Yang Yanling He
author_sort	Fei Qi
title	Psoriasis to Psoriatic Arthritis: The Application of Proteomics Technologies
title_short	Psoriasis to Psoriatic Arthritis: The Application of Proteomics Technologies
title_full	Psoriasis to Psoriatic Arthritis: The Application of Proteomics Technologies
title_fullStr	Psoriasis to Psoriatic Arthritis: The Application of Proteomics Technologies
title_full_unstemmed	Psoriasis to Psoriatic Arthritis: The Application of Proteomics Technologies
title_sort	psoriasis to psoriatic arthritis: the application of proteomics technologies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c4115c9fe8ba4b2c8c14efcad5deb5dd
work_keys_str_mv	AT feiqi psoriasistopsoriaticarthritistheapplicationofproteomicstechnologies AT yaqitan psoriasistopsoriaticarthritistheapplicationofproteomicstechnologies AT aminyao psoriasistopsoriaticarthritistheapplicationofproteomicstechnologies AT xutongyang psoriasistopsoriaticarthritistheapplicationofproteomicstechnologies AT yanlinghe psoriasistopsoriaticarthritistheapplicationofproteomicstechnologies
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Psoriasis to Psoriatic Arthritis: The Application of Proteomics Technologies

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