Colorectal cancer migration and invasion initiated by microRNA-106a.

MicroRNAs have been implicated in the regulation of several cellular signaling pathways of colorectal cancer (CRC) cells. Although emerging evidence proves that microRNA (miR)-106a is expressed highly in primary tumor and stool samples of CRC patients; whether or not miR-106a mediates cancer metasta...

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Autores principales:	Bo Feng, Tao Tao Dong, Lin Lin Wang, Hou Min Zhou, Hong Chao Zhao, Feng Dong, Min Hua Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4128a0a4ef542ea9b688645bd425c7f
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spelling	oai:doaj.org-article:c4128a0a4ef542ea9b688645bd425c7f2021-11-18T07:08:21ZColorectal cancer migration and invasion initiated by microRNA-106a.1932-620310.1371/journal.pone.0043452https://doaj.org/article/c4128a0a4ef542ea9b688645bd425c7f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22912877/?tool=EBIhttps://doaj.org/toc/1932-6203MicroRNAs have been implicated in the regulation of several cellular signaling pathways of colorectal cancer (CRC) cells. Although emerging evidence proves that microRNA (miR)-106a is expressed highly in primary tumor and stool samples of CRC patients; whether or not miR-106a mediates cancer metastasis is unknown. We show here that miR-106a is highly expressed in metastatic CRC cells, and regulates cancer cell migration and invasion positively in vitro and in vivo. These phenotypes do not involve confounding influences on cancer cell proliferation. MiR-106a inhibits the expression of transforming growth factor-β receptor 2 (TGFBR2), leading to increased CRC cell migration and invasion. Importantly, miR-106a expression levels in primary CRCs are correlated with clinical cancer progression. These observations indicate that miR-106a inhibits the anti-metastatic target directly and results in CRC cell migration and invasion.Bo FengTao Tao DongLin Lin WangHou Min ZhouHong Chao ZhaoFeng DongMin Hua ZhengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43452 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bo Feng Tao Tao Dong Lin Lin Wang Hou Min Zhou Hong Chao Zhao Feng Dong Min Hua Zheng Colorectal cancer migration and invasion initiated by microRNA-106a.
description	MicroRNAs have been implicated in the regulation of several cellular signaling pathways of colorectal cancer (CRC) cells. Although emerging evidence proves that microRNA (miR)-106a is expressed highly in primary tumor and stool samples of CRC patients; whether or not miR-106a mediates cancer metastasis is unknown. We show here that miR-106a is highly expressed in metastatic CRC cells, and regulates cancer cell migration and invasion positively in vitro and in vivo. These phenotypes do not involve confounding influences on cancer cell proliferation. MiR-106a inhibits the expression of transforming growth factor-β receptor 2 (TGFBR2), leading to increased CRC cell migration and invasion. Importantly, miR-106a expression levels in primary CRCs are correlated with clinical cancer progression. These observations indicate that miR-106a inhibits the anti-metastatic target directly and results in CRC cell migration and invasion.
format	article
author	Bo Feng Tao Tao Dong Lin Lin Wang Hou Min Zhou Hong Chao Zhao Feng Dong Min Hua Zheng
author_facet	Bo Feng Tao Tao Dong Lin Lin Wang Hou Min Zhou Hong Chao Zhao Feng Dong Min Hua Zheng
author_sort	Bo Feng
title	Colorectal cancer migration and invasion initiated by microRNA-106a.
title_short	Colorectal cancer migration and invasion initiated by microRNA-106a.
title_full	Colorectal cancer migration and invasion initiated by microRNA-106a.
title_fullStr	Colorectal cancer migration and invasion initiated by microRNA-106a.
title_full_unstemmed	Colorectal cancer migration and invasion initiated by microRNA-106a.
title_sort	colorectal cancer migration and invasion initiated by microrna-106a.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c4128a0a4ef542ea9b688645bd425c7f
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Colorectal cancer migration and invasion initiated by microRNA-106a.

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