Porous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract

Abstract In the present study, we successfully synthesized a porous three-dimensional Prussian blue-cellulose aerogel (PB-CA) composite and used it as a decorporation agent for the selective removal of ingested cesium ions (Cs+) from the gastrointestinal (GI) tract. The safety of the PB-CA composite...

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Autores principales:	Ilsong Lee, Sung-Hyun Kim, Muruganantham Rethinasabapathy, Yuvaraj Haldorai, Go-Woon Lee, Sang Rak Choe, Sung-Chan Jang, Sung-Min Kang, Young-Kyu Han, Changhyun Roh, Wan-Seob Cho, Yun Suk Huh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c418710d297c427ab043497a19e7031d
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spelling	oai:doaj.org-article:c418710d297c427ab043497a19e7031d2021-12-02T15:07:51ZPorous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract10.1038/s41598-018-22715-w2045-2322https://doaj.org/article/c418710d297c427ab043497a19e7031d2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22715-whttps://doaj.org/toc/2045-2322Abstract In the present study, we successfully synthesized a porous three-dimensional Prussian blue-cellulose aerogel (PB-CA) composite and used it as a decorporation agent for the selective removal of ingested cesium ions (Cs+) from the gastrointestinal (GI) tract. The safety of the PB-CA composite was evaluated through an in vitro cytotoxicity study using macrophage-like THP-1 cells and Caco-2 intestinal epithelial cells. The results revealed that the PB-CA composite was not cytotoxic. An adsorption study to examine the efficiency of the decorporation agent was conducted using a simulated intestinal fluid (SIF). The adsorption isotherm was fitted to the Langmuir model with a maximum Cs+ adsorption capacity of 13.70 mg/g in SIF that followed pseudo-second-order kinetics. The PB-CA composite showed excellent stability in SIF with a maximum Cs+ removal efficiency of 99.43%. The promising safety toxicology profile, remarkable Cs+ adsorption efficacy, and excellent stability of the composite demonstrated its great potential for use as an orally administered drug for the decorporation of Cs+ from the GI tract.Ilsong LeeSung-Hyun KimMuruganantham RethinasabapathyYuvaraj HaldoraiGo-Woon LeeSang Rak ChoeSung-Chan JangSung-Min KangYoung-Kyu HanChanghyun RohWan-Seob ChoYun Suk HuhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ilsong Lee Sung-Hyun Kim Muruganantham Rethinasabapathy Yuvaraj Haldorai Go-Woon Lee Sang Rak Choe Sung-Chan Jang Sung-Min Kang Young-Kyu Han Changhyun Roh Wan-Seob Cho Yun Suk Huh Porous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract
description	Abstract In the present study, we successfully synthesized a porous three-dimensional Prussian blue-cellulose aerogel (PB-CA) composite and used it as a decorporation agent for the selective removal of ingested cesium ions (Cs+) from the gastrointestinal (GI) tract. The safety of the PB-CA composite was evaluated through an in vitro cytotoxicity study using macrophage-like THP-1 cells and Caco-2 intestinal epithelial cells. The results revealed that the PB-CA composite was not cytotoxic. An adsorption study to examine the efficiency of the decorporation agent was conducted using a simulated intestinal fluid (SIF). The adsorption isotherm was fitted to the Langmuir model with a maximum Cs+ adsorption capacity of 13.70 mg/g in SIF that followed pseudo-second-order kinetics. The PB-CA composite showed excellent stability in SIF with a maximum Cs+ removal efficiency of 99.43%. The promising safety toxicology profile, remarkable Cs+ adsorption efficacy, and excellent stability of the composite demonstrated its great potential for use as an orally administered drug for the decorporation of Cs+ from the GI tract.
format	article
author	Ilsong Lee Sung-Hyun Kim Muruganantham Rethinasabapathy Yuvaraj Haldorai Go-Woon Lee Sang Rak Choe Sung-Chan Jang Sung-Min Kang Young-Kyu Han Changhyun Roh Wan-Seob Cho Yun Suk Huh
author_facet	Ilsong Lee Sung-Hyun Kim Muruganantham Rethinasabapathy Yuvaraj Haldorai Go-Woon Lee Sang Rak Choe Sung-Chan Jang Sung-Min Kang Young-Kyu Han Changhyun Roh Wan-Seob Cho Yun Suk Huh
author_sort	Ilsong Lee
title	Porous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract
title_short	Porous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract
title_full	Porous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract
title_fullStr	Porous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract
title_full_unstemmed	Porous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract
title_sort	porous 3d prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c418710d297c427ab043497a19e7031d
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Porous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract

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