The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant

Haiyan Wang, 1 Qiuping Xu, 1 Hui Hu, 2 Chunling Shi, 3 Ziyan Lin, 3 Huixi Jiang, 3 Huaipu Dong, 3 Jing Guo 1 1Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shan...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang H, Xu Q, Hu H, Shi C, Lin Z, Jiang H, Dong H, Guo J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	titanium alkali-heat treatment magnetron sputtering osteogenic differentiation osteoclast inhibition Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c41b8d0de50d487ba1f9ae9c9d28f4aa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c41b8d0de50d487ba1f9ae9c9d28f4aa
record_format	dspace
spelling	oai:doaj.org-article:c41b8d0de50d487ba1f9ae9c9d28f4aa2021-12-02T13:42:17ZThe Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant1178-2013https://doaj.org/article/c41b8d0de50d487ba1f9ae9c9d28f4aa2020-11-01T00:00:00Zhttps://www.dovepress.com/the-fabrication-and-function-of-strontium-modified-hierarchical-micron-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Haiyan Wang, 1 Qiuping Xu, 1 Hui Hu, 2 Chunling Shi, 3 Ziyan Lin, 3 Huixi Jiang, 3 Huaipu Dong, 3 Jing Guo 1 1Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong, 250012, People’s Republic of China; 2Osaka Dental University Kusuha School, Hirakata City, Osaka 573-1121, Japan; 3School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, People’s Republic of ChinaCorrespondence: Jing GuoDepartment of Orthodontics, Room 201, School and Hospital of Stomatology, Shandong University, 44-1 Wenhua West Road, Jinan, Shandong 250012, Mainland ChinaEmail guojing@sdu.edu.cnBackground: Relying on surface topography alone to enhance the osteointegration of implants is still inadequate. An effective way to combine long-term ion release and surface topography to enhance osteogenic property is urgently needed.Purpose: The objective of this study is to fabricate a long-term strontium ion release implant system and confirm the biological function in vitro and in vivo.Methods: The biomimic surface was fabricated through alkali-heat treatment and magnetron sputtering. The in vitro biological function assays were determined by MTT, fluorescence staining, alkaline phosphatase activity, extracellular mineralization, and quantitative real-time polymerase chain reaction assays. The in vivo experiments were detected by micro-CT, HE staining and Masson staining.Results: The biomimic surface structure has been successfully fabricated. The in vitro cell assays determined that AH-Ti/Sr90 possessed the best biological function. The in vivo experiments demonstrated that AH-Ti/Sr90 could promote osteointegration significantly under both in normal and osteoporotic conditions.Conclusion: We determined that AH-Ti/Sr90 possesses the best osteogenic property, long-term ion release capacity and osteointegration promotion ability. It has potential clinic application prospects.Keywords: titanium, alkali-heat treatment, magnetron sputtering, osteogenic differentiation, osteoclast inhibitionWang HXu QHu HShi CLin ZJiang HDong HGuo JDove Medical Pressarticletitaniumalkali-heat treatmentmagnetron sputteringosteogenic differentiationosteoclast inhibitionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8983-8998 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	titanium alkali-heat treatment magnetron sputtering osteogenic differentiation osteoclast inhibition Medicine (General) R5-920
spellingShingle	titanium alkali-heat treatment magnetron sputtering osteogenic differentiation osteoclast inhibition Medicine (General) R5-920 Wang H Xu Q Hu H Shi C Lin Z Jiang H Dong H Guo J The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant
description	Haiyan Wang, 1 Qiuping Xu, 1 Hui Hu, 2 Chunling Shi, 3 Ziyan Lin, 3 Huixi Jiang, 3 Huaipu Dong, 3 Jing Guo 1 1Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong, 250012, People’s Republic of China; 2Osaka Dental University Kusuha School, Hirakata City, Osaka 573-1121, Japan; 3School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, People’s Republic of ChinaCorrespondence: Jing GuoDepartment of Orthodontics, Room 201, School and Hospital of Stomatology, Shandong University, 44-1 Wenhua West Road, Jinan, Shandong 250012, Mainland ChinaEmail guojing@sdu.edu.cnBackground: Relying on surface topography alone to enhance the osteointegration of implants is still inadequate. An effective way to combine long-term ion release and surface topography to enhance osteogenic property is urgently needed.Purpose: The objective of this study is to fabricate a long-term strontium ion release implant system and confirm the biological function in vitro and in vivo.Methods: The biomimic surface was fabricated through alkali-heat treatment and magnetron sputtering. The in vitro biological function assays were determined by MTT, fluorescence staining, alkaline phosphatase activity, extracellular mineralization, and quantitative real-time polymerase chain reaction assays. The in vivo experiments were detected by micro-CT, HE staining and Masson staining.Results: The biomimic surface structure has been successfully fabricated. The in vitro cell assays determined that AH-Ti/Sr90 possessed the best biological function. The in vivo experiments demonstrated that AH-Ti/Sr90 could promote osteointegration significantly under both in normal and osteoporotic conditions.Conclusion: We determined that AH-Ti/Sr90 possesses the best osteogenic property, long-term ion release capacity and osteointegration promotion ability. It has potential clinic application prospects.Keywords: titanium, alkali-heat treatment, magnetron sputtering, osteogenic differentiation, osteoclast inhibition
format	article
author	Wang H Xu Q Hu H Shi C Lin Z Jiang H Dong H Guo J
author_facet	Wang H Xu Q Hu H Shi C Lin Z Jiang H Dong H Guo J
author_sort	Wang H
title	The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant
title_short	The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant
title_full	The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant
title_fullStr	The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant
title_full_unstemmed	The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant
title_sort	fabrication and function of strontium-modified hierarchical micro/nano titanium implant
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/c41b8d0de50d487ba1f9ae9c9d28f4aa
work_keys_str_mv	AT wangh thefabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT xuq thefabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT huh thefabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT shic thefabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT linz thefabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT jiangh thefabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT dongh thefabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT guoj thefabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT wangh fabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT xuq fabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT huh fabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT shic fabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT linz fabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT jiangh fabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT dongh fabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant AT guoj fabricationandfunctionofstrontiummodifiedhierarchicalmicronanotitaniumimplant
_version_	1718392580304011264

The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant

Ejemplares similares