Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

Cytokines critically control the differentiation and functions of activated naïve and memory T cells. Here the authors show, using multi-omics and single-cell analyses, that naïve and memory T cells exhibit distinct cytokine responses, in which an ‘effectorness gradient’ is depicted by a transcripti...

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Autores principales:	Eddie Cano-Gamez, Blagoje Soskic, Theodoros I. Roumeliotis, Ernest So, Deborah J. Smyth, Marta Baldrighi, David Willé, Nikolina Nakic, Jorge Esparza-Gordillo, Christopher G. C. Larminie, Paola G. Bronson, David F. Tough, Wendy C. Rowan, Jyoti S. Choudhary, Gosia Trynka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c41d5eba344a432094f61c1d23ca9074
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spelling	oai:doaj.org-article:c41d5eba344a432094f61c1d23ca90742021-12-02T14:41:02ZSingle-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines10.1038/s41467-020-15543-y2041-1723https://doaj.org/article/c41d5eba344a432094f61c1d23ca90742020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15543-yhttps://doaj.org/toc/2041-1723Cytokines critically control the differentiation and functions of activated naïve and memory T cells. Here the authors show, using multi-omics and single-cell analyses, that naïve and memory T cells exhibit distinct cytokine responses, in which an ‘effectorness gradient’ is depicted by a transcriptional continuum, which shapes the downstream genetic programs.Eddie Cano-GamezBlagoje SoskicTheodoros I. RoumeliotisErnest SoDeborah J. SmythMarta BaldrighiDavid WilléNikolina NakicJorge Esparza-GordilloChristopher G. C. LarminiePaola G. BronsonDavid F. ToughWendy C. RowanJyoti S. ChoudharyGosia TrynkaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eddie Cano-Gamez Blagoje Soskic Theodoros I. Roumeliotis Ernest So Deborah J. Smyth Marta Baldrighi David Willé Nikolina Nakic Jorge Esparza-Gordillo Christopher G. C. Larminie Paola G. Bronson David F. Tough Wendy C. Rowan Jyoti S. Choudhary Gosia Trynka Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
description	Cytokines critically control the differentiation and functions of activated naïve and memory T cells. Here the authors show, using multi-omics and single-cell analyses, that naïve and memory T cells exhibit distinct cytokine responses, in which an ‘effectorness gradient’ is depicted by a transcriptional continuum, which shapes the downstream genetic programs.
format	article
author	Eddie Cano-Gamez Blagoje Soskic Theodoros I. Roumeliotis Ernest So Deborah J. Smyth Marta Baldrighi David Willé Nikolina Nakic Jorge Esparza-Gordillo Christopher G. C. Larminie Paola G. Bronson David F. Tough Wendy C. Rowan Jyoti S. Choudhary Gosia Trynka
author_facet	Eddie Cano-Gamez Blagoje Soskic Theodoros I. Roumeliotis Ernest So Deborah J. Smyth Marta Baldrighi David Willé Nikolina Nakic Jorge Esparza-Gordillo Christopher G. C. Larminie Paola G. Bronson David F. Tough Wendy C. Rowan Jyoti S. Choudhary Gosia Trynka
author_sort	Eddie Cano-Gamez
title	Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
title_short	Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
title_full	Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
title_fullStr	Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
title_full_unstemmed	Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
title_sort	single-cell transcriptomics identifies an effectorness gradient shaping the response of cd4+ t cells to cytokines
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c41d5eba344a432094f61c1d23ca9074
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Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

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