Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
Cytokines critically control the differentiation and functions of activated naïve and memory T cells. Here the authors show, using multi-omics and single-cell analyses, that naïve and memory T cells exhibit distinct cytokine responses, in which an ‘effectorness gradient’ is depicted by a transcripti...
Guardado en:
Autores principales: | Eddie Cano-Gamez, Blagoje Soskic, Theodoros I. Roumeliotis, Ernest So, Deborah J. Smyth, Marta Baldrighi, David Willé, Nikolina Nakic, Jorge Esparza-Gordillo, Christopher G. C. Larminie, Paola G. Bronson, David F. Tough, Wendy C. Rowan, Jyoti S. Choudhary, Gosia Trynka |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/c41d5eba344a432094f61c1d23ca9074 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Functional studies of GWAS variants are gaining momentum
por: Florence Lichou, et al.
Publicado: (2020) -
Intestinal Epithelial Cells and the Microbiome Undergo Swift Reprogramming at the Inception of Colonic <named-content content-type="genus-species">Citrobacter rodentium</named-content> Infection
por: Eve G. D. Hopkins, et al.
Publicado: (2019) -
Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals
por: Evaggelia Liaskou, et al.
Publicado: (2017) -
An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules
por: Gábor Bakos, et al.
Publicado: (2018) -
Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
por: Amy T. Y. Yeung, et al.
Publicado: (2017)