The Pathogenic Potential of a Microbe

ABSTRACT Virulence is a microbial property that is realized only in susceptible hosts. There is no absolute measurement for virulence, and consequently it is always measured relative to a standard, usually another microbe or host. This article introduces the concept of pathogenic potential, which pr...

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Autor principal:	Arturo Casadevall
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	formula pathogenesis virulence Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c423e1edd4a244c6b6639f3487ecc213
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spelling	oai:doaj.org-article:c423e1edd4a244c6b6639f3487ecc2132021-11-15T15:22:04ZThe Pathogenic Potential of a Microbe10.1128/mSphere.00015-172379-5042https://doaj.org/article/c423e1edd4a244c6b6639f3487ecc2132017-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00015-17https://doaj.org/toc/2379-5042ABSTRACT Virulence is a microbial property that is realized only in susceptible hosts. There is no absolute measurement for virulence, and consequently it is always measured relative to a standard, usually another microbe or host. This article introduces the concept of pathogenic potential, which provides a new approach to measuring the capacity of microbes for virulence. The pathogenic potential is proportional to the fraction of individuals who become symptomatic after infection with a defined inoculum and can include such attributes as mortality, communicability, and the time from infection to disease. The calculation of the pathogenic potential has significant advantages over the use of the lethal dose that kills 50% of infected individuals (LD50) and allows direct comparisons between individual microbes. An analysis of the pathogenic potential of several microbes for mice reveals a continuum, which in turn supports the view that there is no dividing line between pathogenic and nonpathogenic microbes.Arturo CasadevallAmerican Society for MicrobiologyarticleformulapathogenesisvirulenceMicrobiologyQR1-502ENmSphere, Vol 2, Iss 1 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	formula pathogenesis virulence Microbiology QR1-502
spellingShingle	formula pathogenesis virulence Microbiology QR1-502 Arturo Casadevall The Pathogenic Potential of a Microbe
description	ABSTRACT Virulence is a microbial property that is realized only in susceptible hosts. There is no absolute measurement for virulence, and consequently it is always measured relative to a standard, usually another microbe or host. This article introduces the concept of pathogenic potential, which provides a new approach to measuring the capacity of microbes for virulence. The pathogenic potential is proportional to the fraction of individuals who become symptomatic after infection with a defined inoculum and can include such attributes as mortality, communicability, and the time from infection to disease. The calculation of the pathogenic potential has significant advantages over the use of the lethal dose that kills 50% of infected individuals (LD50) and allows direct comparisons between individual microbes. An analysis of the pathogenic potential of several microbes for mice reveals a continuum, which in turn supports the view that there is no dividing line between pathogenic and nonpathogenic microbes.
format	article
author	Arturo Casadevall
author_facet	Arturo Casadevall
author_sort	Arturo Casadevall
title	The Pathogenic Potential of a Microbe
title_short	The Pathogenic Potential of a Microbe
title_full	The Pathogenic Potential of a Microbe
title_fullStr	The Pathogenic Potential of a Microbe
title_full_unstemmed	The Pathogenic Potential of a Microbe
title_sort	pathogenic potential of a microbe
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/c423e1edd4a244c6b6639f3487ecc213
work_keys_str_mv	AT arturocasadevall thepathogenicpotentialofamicrobe AT arturocasadevall pathogenicpotentialofamicrobe
_version_	1718428095951667200

The Pathogenic Potential of a Microbe

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