FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CUTANEOUS AND MUCOSAL LESIONS OF CERVIX UTERI, ASSOCIATED WITH PAPILLOMAVIRUS INFECTION

Human papillomaviruses (HPV) infection are considered as a triggering factor of cervical neoplastic events (e.g., CIN) and are responsible for many cutaneous and mucosal lesions of cervix uteri. CIN commonly emerges from benign cervical tissue changes. There is clear evidence that local immune respo...

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Autor principal:	O. S. Abramovskikh
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	papillomavirus infection cervical intraepithelial neoplasia neutrophiles immunity cervix uteri Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c425f07304764eb19ea1ab5c62c2a8cd
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spelling	oai:doaj.org-article:c425f07304764eb19ea1ab5c62c2a8cd2021-11-18T08:03:38ZFUNCTIONAL ACTIVITY OF NEUTROPHILS IN CUTANEOUS AND MUCOSAL LESIONS OF CERVIX UTERI, ASSOCIATED WITH PAPILLOMAVIRUS INFECTION1563-06252313-741X10.15789/1563-0625-2010-4-5-409-412https://doaj.org/article/c425f07304764eb19ea1ab5c62c2a8cd2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/225https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XHuman papillomaviruses (HPV) infection are considered as a triggering factor of cervical neoplastic events (e.g., CIN) and are responsible for many cutaneous and mucosal lesions of cervix uteri. CIN commonly emerges from benign cervical tissue changes. There is clear evidence that local immune response in reproductive system plays a major role in the control and course of benign cervical tissue changes. Neutrophils play main role in encountering pathogens, primary antigen reactions and mediate powerful inflammatory effects. They are involved into development of antitumor response. The main purpose of our investigation was to study some indexes of neutrophil functional activity in women with CIN II-III associated with HPV-infection. It was shown that considerable changes in functional activity of neutrophils in mucous cervical secretions from women with CIN II-III, as compared to patients with chronic inflammation, accompanied by benign cervical changes (cervical ectopia). The alterations of neutrophil functional activity in women with CIN II-III may sustain a local chronic inflammation, associated with HPV-infection, thus increasing probability and predicting a of higher-grade tumor disease.O. S. AbramovskikhSPb RAACIarticlepapillomavirus infectioncervical intraepithelial neoplasianeutrophilesimmunitycervix uteriImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 409-412 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	papillomavirus infection cervical intraepithelial neoplasia neutrophiles immunity cervix uteri Immunologic diseases. Allergy RC581-607
spellingShingle	papillomavirus infection cervical intraepithelial neoplasia neutrophiles immunity cervix uteri Immunologic diseases. Allergy RC581-607 O. S. Abramovskikh FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CUTANEOUS AND MUCOSAL LESIONS OF CERVIX UTERI, ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
description	Human papillomaviruses (HPV) infection are considered as a triggering factor of cervical neoplastic events (e.g., CIN) and are responsible for many cutaneous and mucosal lesions of cervix uteri. CIN commonly emerges from benign cervical tissue changes. There is clear evidence that local immune response in reproductive system plays a major role in the control and course of benign cervical tissue changes. Neutrophils play main role in encountering pathogens, primary antigen reactions and mediate powerful inflammatory effects. They are involved into development of antitumor response. The main purpose of our investigation was to study some indexes of neutrophil functional activity in women with CIN II-III associated with HPV-infection. It was shown that considerable changes in functional activity of neutrophils in mucous cervical secretions from women with CIN II-III, as compared to patients with chronic inflammation, accompanied by benign cervical changes (cervical ectopia). The alterations of neutrophil functional activity in women with CIN II-III may sustain a local chronic inflammation, associated with HPV-infection, thus increasing probability and predicting a of higher-grade tumor disease.
format	article
author	O. S. Abramovskikh
author_facet	O. S. Abramovskikh
author_sort	O. S. Abramovskikh
title	FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CUTANEOUS AND MUCOSAL LESIONS OF CERVIX UTERI, ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_short	FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CUTANEOUS AND MUCOSAL LESIONS OF CERVIX UTERI, ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_full	FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CUTANEOUS AND MUCOSAL LESIONS OF CERVIX UTERI, ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_fullStr	FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CUTANEOUS AND MUCOSAL LESIONS OF CERVIX UTERI, ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_full_unstemmed	FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CUTANEOUS AND MUCOSAL LESIONS OF CERVIX UTERI, ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_sort	functional activity of neutrophils in cutaneous and mucosal lesions of cervix uteri, associated with papillomavirus infection
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/c425f07304764eb19ea1ab5c62c2a8cd
work_keys_str_mv	AT osabramovskikh functionalactivityofneutrophilsincutaneousandmucosallesionsofcervixuteriassociatedwithpapillomavirusinfection
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FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CUTANEOUS AND MUCOSAL LESIONS OF CERVIX UTERI, ASSOCIATED WITH PAPILLOMAVIRUS INFECTION

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