Portable all-in-one automated microfluidic system (PAMICON) with 3D-printed chip using novel fluid control mechanism

Abstract State-of-the-art microfluidic systems rely on relatively expensive and bulky off-chip infrastructures. The core of a system—the microfluidic chip—requires a clean room and dedicated skills to be fabricated. Thus, state-of-the-art microfluidic systems are barely accessible, especially for th...

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Autores principales:	Yushen Zhang, Tsun-Ming Tseng, Ulf Schlichtmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c428334e163c45e1a5706c016f10ea44
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spelling	oai:doaj.org-article:c428334e163c45e1a5706c016f10ea442021-12-02T19:16:54ZPortable all-in-one automated microfluidic system (PAMICON) with 3D-printed chip using novel fluid control mechanism10.1038/s41598-021-98655-92045-2322https://doaj.org/article/c428334e163c45e1a5706c016f10ea442021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98655-9https://doaj.org/toc/2045-2322Abstract State-of-the-art microfluidic systems rely on relatively expensive and bulky off-chip infrastructures. The core of a system—the microfluidic chip—requires a clean room and dedicated skills to be fabricated. Thus, state-of-the-art microfluidic systems are barely accessible, especially for the do-it-yourself (DIY) community or enthusiasts. Recent emerging technology—3D-printing—has shown promise to fabricate microfluidic chips more simply, but the resulting chip is mainly hardened and single-layered and can hardly replace the state-of-the-art Polydimethylsiloxane (PDMS) chip. There exists no convenient fluidic control mechanism yet suitable for the hardened single-layered chip, and particularly, the hardened single-layered chip cannot replicate the pneumatic valve—an essential actuator for automatically controlled microfluidics. Instead, 3D-printable non-pneumatic or manually actuated valve designs are reported, but their application is limited. Here, we present a low-cost accessible all-in-one portable microfluidic system, which uses an easy-to-print single-layered 3D-printed microfluidic chip along with a novel active control mechanism for fluids to enable more applications. This active control mechanism is based on air or gas interception and can, e.g., block, direct, and transport fluid. As a demonstration, we show the system can automatically control the fluid in microfluidic chips, which we designed and printed with a consumer-grade 3D-printer. The system is comparably compact and can automatically perform user-programmed experiments. All operations can be done directly on the system with no additional host device required. This work could support the spread of low budget accessible microfluidic systems as portable, usable on-the-go devices and increase the application field of 3D-printed microfluidic devices.Yushen ZhangTsun-Ming TsengUlf SchlichtmannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yushen Zhang Tsun-Ming Tseng Ulf Schlichtmann Portable all-in-one automated microfluidic system (PAMICON) with 3D-printed chip using novel fluid control mechanism
description	Abstract State-of-the-art microfluidic systems rely on relatively expensive and bulky off-chip infrastructures. The core of a system—the microfluidic chip—requires a clean room and dedicated skills to be fabricated. Thus, state-of-the-art microfluidic systems are barely accessible, especially for the do-it-yourself (DIY) community or enthusiasts. Recent emerging technology—3D-printing—has shown promise to fabricate microfluidic chips more simply, but the resulting chip is mainly hardened and single-layered and can hardly replace the state-of-the-art Polydimethylsiloxane (PDMS) chip. There exists no convenient fluidic control mechanism yet suitable for the hardened single-layered chip, and particularly, the hardened single-layered chip cannot replicate the pneumatic valve—an essential actuator for automatically controlled microfluidics. Instead, 3D-printable non-pneumatic or manually actuated valve designs are reported, but their application is limited. Here, we present a low-cost accessible all-in-one portable microfluidic system, which uses an easy-to-print single-layered 3D-printed microfluidic chip along with a novel active control mechanism for fluids to enable more applications. This active control mechanism is based on air or gas interception and can, e.g., block, direct, and transport fluid. As a demonstration, we show the system can automatically control the fluid in microfluidic chips, which we designed and printed with a consumer-grade 3D-printer. The system is comparably compact and can automatically perform user-programmed experiments. All operations can be done directly on the system with no additional host device required. This work could support the spread of low budget accessible microfluidic systems as portable, usable on-the-go devices and increase the application field of 3D-printed microfluidic devices.
format	article
author	Yushen Zhang Tsun-Ming Tseng Ulf Schlichtmann
author_facet	Yushen Zhang Tsun-Ming Tseng Ulf Schlichtmann
author_sort	Yushen Zhang
title	Portable all-in-one automated microfluidic system (PAMICON) with 3D-printed chip using novel fluid control mechanism
title_short	Portable all-in-one automated microfluidic system (PAMICON) with 3D-printed chip using novel fluid control mechanism
title_full	Portable all-in-one automated microfluidic system (PAMICON) with 3D-printed chip using novel fluid control mechanism
title_fullStr	Portable all-in-one automated microfluidic system (PAMICON) with 3D-printed chip using novel fluid control mechanism
title_full_unstemmed	Portable all-in-one automated microfluidic system (PAMICON) with 3D-printed chip using novel fluid control mechanism
title_sort	portable all-in-one automated microfluidic system (pamicon) with 3d-printed chip using novel fluid control mechanism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c428334e163c45e1a5706c016f10ea44
work_keys_str_mv	AT yushenzhang portableallinoneautomatedmicrofluidicsystempamiconwith3dprintedchipusingnovelfluidcontrolmechanism AT tsunmingtseng portableallinoneautomatedmicrofluidicsystempamiconwith3dprintedchipusingnovelfluidcontrolmechanism AT ulfschlichtmann portableallinoneautomatedmicrofluidicsystempamiconwith3dprintedchipusingnovelfluidcontrolmechanism
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Portable all-in-one automated microfluidic system (PAMICON) with 3D-printed chip using novel fluid control mechanism

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