Salicylic diamines selectively eliminate residual undifferentiated cells from pluripotent stem cell-derived cardiomyocyte preparations
Abstract Clinical translation of pluripotent stem cell (PSC) derivatives is hindered by the tumorigenic risk from residual undifferentiated cells. Here, we identified salicylic diamines as potent agents exhibiting toxicity to murine and human PSCs but not to cardiomyocytes (CMs) derived from them. H...
Guardado en:
Autores principales: | Karsten Burkert, Hadiseh Taheri, Sarkawt Hamad, Matteo Oliverio, Gabriel Peinkofer, Jan-Wilhelm Kornfeld, Wacharee Harnying, Kurt Pfannkuche, Jürgen Hescheler, Albrecht Berkessel, Tomo Šarić |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/c42a4101eb364861aadfd22f6d533faa |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Elimination of undifferentiated human embryonic stem cells by cardiac glycosides
por: Yu-Tsen Lin, et al.
Publicado: (2017) -
Identification of dynamic undifferentiated cell states within the male germline
por: Hue M. La, et al.
Publicado: (2018) -
Robust detection of undifferentiated iPSC among differentiated cells
por: Keisuke Sekine, et al.
Publicado: (2020) -
MRI-based identification of undifferentiated cells: looking at the two faces of Janus
por: Tomuleasa C, et al.
Publicado: (2014) -
Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets
por: Catherine J. Jackson, et al.
Publicado: (2017)