Efficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study A1chive

Modern insulin analogues allow safe improvement of glycemic control (not accompanied with increase in body mass or rate of severe hypoglycemic events) and its efficient maintenance during long period of time. In this paper we present results of multicenter 52-week prospective observational study A1c...

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Autor principal:	Marina Vladimirovna Shestakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2012
Materias:	a1chieve diabetes mellitus type 2 observational study insulin analogues Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/c42b5ab1daef423cacf69596a35500eb
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spelling	oai:doaj.org-article:c42b5ab1daef423cacf69596a35500eb2021-11-14T09:00:17ZEfficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study A1chive2072-03512072-037810.14341/2072-0351-5548https://doaj.org/article/c42b5ab1daef423cacf69596a35500eb2012-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5548https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Modern insulin analogues allow safe improvement of glycemic control (not accompanied with increase in body mass or rate of severe hypoglycemic events) and its efficient maintenance during long period of time. In this paper we present results of multicenter 52-week prospective observational study A1chive (Russian cohort, n=9342), designed to assess safety and efficacy of treatment with human insulin analogues (Levemir?, NovoMix? 30 and NovoRapid? (Novo Nordisk) in daily management of insulin naive patients with type 2 diabetes mellitus. Prescription of human insulin analogues resulted in clinically and statistically significant improvement of glycemic control irrespective of initial insulin regimen. Therapy by various regimens (Levemir?, NovoMix? 30 or Levemir? + NovoRapid?) under conditions of daily clinical practice leads to marked improvement in glycemic control as measured by HbA1c (-2.9% in 12 month) with no evidence for negative influence on tolerability and short-term safety of the treatment. Furthermore, decrease in HbA1c levels was associated with pronounced and stable decrease in fasting and postprandial glucose levels (-5.0 mmol/L and -5.7 mmol/L, respectively). By the end of the follow-up all regimen groups reported improvement of QoL by treatment satisfaction criterion.Marina Vladimirovna ShestakovaEndocrinology Research Centrearticlea1chievediabetes mellitus type 2observational studya1chieveinsulin analoguesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 4, Pp 115-121 (2012)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	a1chieve diabetes mellitus type 2 observational study a1chieve insulin analogues Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	a1chieve diabetes mellitus type 2 observational study a1chieve insulin analogues Nutritional diseases. Deficiency diseases RC620-627 Marina Vladimirovna Shestakova Efficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study A1chive
description	Modern insulin analogues allow safe improvement of glycemic control (not accompanied with increase in body mass or rate of severe hypoglycemic events) and its efficient maintenance during long period of time. In this paper we present results of multicenter 52-week prospective observational study A1chive (Russian cohort, n=9342), designed to assess safety and efficacy of treatment with human insulin analogues (Levemir?, NovoMix? 30 and NovoRapid? (Novo Nordisk) in daily management of insulin naive patients with type 2 diabetes mellitus. Prescription of human insulin analogues resulted in clinically and statistically significant improvement of glycemic control irrespective of initial insulin regimen. Therapy by various regimens (Levemir?, NovoMix? 30 or Levemir? + NovoRapid?) under conditions of daily clinical practice leads to marked improvement in glycemic control as measured by HbA1c (-2.9% in 12 month) with no evidence for negative influence on tolerability and short-term safety of the treatment. Furthermore, decrease in HbA1c levels was associated with pronounced and stable decrease in fasting and postprandial glucose levels (-5.0 mmol/L and -5.7 mmol/L, respectively). By the end of the follow-up all regimen groups reported improvement of QoL by treatment satisfaction criterion.
format	article
author	Marina Vladimirovna Shestakova
author_facet	Marina Vladimirovna Shestakova
author_sort	Marina Vladimirovna Shestakova
title	Efficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study A1chive
title_short	Efficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study A1chive
title_full	Efficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study A1chive
title_fullStr	Efficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study A1chive
title_full_unstemmed	Efficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study A1chive
title_sort	efficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study a1chive
publisher	Endocrinology Research Centre
publishDate	2012
url	https://doaj.org/article/c42b5ab1daef423cacf69596a35500eb
work_keys_str_mv	AT marinavladimirovnashestakova efficacyandsafetyoftreatmentwithhumaninsulinanaloguesindailymanagementofinsulinnaivepatientswithtype2diabetesmellitusresultsofmulticenter52weekobservationalstudya1chive
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Efficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study A1chive

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