Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

Muscle weakness has been associated with morbidity and mortality in older people. Here, the authors have investigated this trait further by performing a genome-wide meta-analysis of grip strength and Mendelian randomization to discover causal relationships between muscle weakness and other diseases.

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Autores principales:	Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian’an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle, Megan L. Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Bruce M. Psaty, Michelle C. Odden, Alison E. Fohner, Claudia Langenberg, Nicholas J. Wareham, Stefania Bandinelli, Natasja M. van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellström, Magnus Karlsson, David A. Bennett, Aron S. Buchman, Philip L. De Jager, Andre G. Uitterlinden, Uwe Völker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguéz-Mañas, Francisco J. García, José A. Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M. Murabito, David Melzer, George A. Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Luke C. Pilling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c432b68fa4c74f79a795551d0b9372a0
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spelling	oai:doaj.org-article:c432b68fa4c74f79a795551d0b9372a02021-12-02T13:57:32ZGenome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women10.1038/s41467-021-20918-w2041-1723https://doaj.org/article/c432b68fa4c74f79a795551d0b9372a02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20918-whttps://doaj.org/toc/2041-1723Muscle weakness has been associated with morbidity and mortality in older people. Here, the authors have investigated this trait further by performing a genome-wide meta-analysis of grip strength and Mendelian randomization to discover causal relationships between muscle weakness and other diseases.Garan JonesKaterina TrajanoskaAdam J. SantanastoNajada StringaChia-Ling KuoJanice L. AtkinsJoshua R. LewisThuyVy DuongShengjun HongMary L. BiggsJian’an LuanChloe SarnowskiKathryn L. LunettaToshiko TanakaMary K. WojczynskiRyan CvejkusMaria NethanderSahar GhasemiJingyun YangM. Carola ZillikensStefan WalterKamil SicinskiErika KagueCheryl L. Ackert-BicknellDan E. ArkingB. Gwen WindhamEric BoerwinkleMegan L. GroveMisa GraffDominik SpiraIlja DemuthNathalie van der VeldeLisette C. P. G. M. de GrootBruce M. PsatyMichelle C. OddenAlison E. FohnerClaudia LangenbergNicholas J. WarehamStefania BandinelliNatasja M. van SchoorMartijn HuismanQihua TanJoseph ZmudaDan MellströmMagnus KarlssonDavid A. BennettAron S. BuchmanPhilip L. De JagerAndre G. UitterlindenUwe VölkerThomas KocherAlexander TeumerLeocadio Rodriguéz-MañasFrancisco J. GarcíaJosé A. CarniceroPamela HerdLars BertramClaes OhlssonJoanne M. MurabitoDavid MelzerGeorge A. KuchelLuigi FerrucciDavid KarasikFernando RivadeneiraDouglas P. KielLuke C. PillingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Garan Jones Katerina Trajanoska Adam J. Santanasto Najada Stringa Chia-Ling Kuo Janice L. Atkins Joshua R. Lewis ThuyVy Duong Shengjun Hong Mary L. Biggs Jian’an Luan Chloe Sarnowski Kathryn L. Lunetta Toshiko Tanaka Mary K. Wojczynski Ryan Cvejkus Maria Nethander Sahar Ghasemi Jingyun Yang M. Carola Zillikens Stefan Walter Kamil Sicinski Erika Kague Cheryl L. Ackert-Bicknell Dan E. Arking B. Gwen Windham Eric Boerwinkle Megan L. Grove Misa Graff Dominik Spira Ilja Demuth Nathalie van der Velde Lisette C. P. G. M. de Groot Bruce M. Psaty Michelle C. Odden Alison E. Fohner Claudia Langenberg Nicholas J. Wareham Stefania Bandinelli Natasja M. van Schoor Martijn Huisman Qihua Tan Joseph Zmuda Dan Mellström Magnus Karlsson David A. Bennett Aron S. Buchman Philip L. De Jager Andre G. Uitterlinden Uwe Völker Thomas Kocher Alexander Teumer Leocadio Rodriguéz-Mañas Francisco J. García José A. Carnicero Pamela Herd Lars Bertram Claes Ohlsson Joanne M. Murabito David Melzer George A. Kuchel Luigi Ferrucci David Karasik Fernando Rivadeneira Douglas P. Kiel Luke C. Pilling Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
description	Muscle weakness has been associated with morbidity and mortality in older people. Here, the authors have investigated this trait further by performing a genome-wide meta-analysis of grip strength and Mendelian randomization to discover causal relationships between muscle weakness and other diseases.
format	article
author	Garan Jones Katerina Trajanoska Adam J. Santanasto Najada Stringa Chia-Ling Kuo Janice L. Atkins Joshua R. Lewis ThuyVy Duong Shengjun Hong Mary L. Biggs Jian’an Luan Chloe Sarnowski Kathryn L. Lunetta Toshiko Tanaka Mary K. Wojczynski Ryan Cvejkus Maria Nethander Sahar Ghasemi Jingyun Yang M. Carola Zillikens Stefan Walter Kamil Sicinski Erika Kague Cheryl L. Ackert-Bicknell Dan E. Arking B. Gwen Windham Eric Boerwinkle Megan L. Grove Misa Graff Dominik Spira Ilja Demuth Nathalie van der Velde Lisette C. P. G. M. de Groot Bruce M. Psaty Michelle C. Odden Alison E. Fohner Claudia Langenberg Nicholas J. Wareham Stefania Bandinelli Natasja M. van Schoor Martijn Huisman Qihua Tan Joseph Zmuda Dan Mellström Magnus Karlsson David A. Bennett Aron S. Buchman Philip L. De Jager Andre G. Uitterlinden Uwe Völker Thomas Kocher Alexander Teumer Leocadio Rodriguéz-Mañas Francisco J. García José A. Carnicero Pamela Herd Lars Bertram Claes Ohlsson Joanne M. Murabito David Melzer George A. Kuchel Luigi Ferrucci David Karasik Fernando Rivadeneira Douglas P. Kiel Luke C. Pilling
author_facet	Garan Jones Katerina Trajanoska Adam J. Santanasto Najada Stringa Chia-Ling Kuo Janice L. Atkins Joshua R. Lewis ThuyVy Duong Shengjun Hong Mary L. Biggs Jian’an Luan Chloe Sarnowski Kathryn L. Lunetta Toshiko Tanaka Mary K. Wojczynski Ryan Cvejkus Maria Nethander Sahar Ghasemi Jingyun Yang M. Carola Zillikens Stefan Walter Kamil Sicinski Erika Kague Cheryl L. Ackert-Bicknell Dan E. Arking B. Gwen Windham Eric Boerwinkle Megan L. Grove Misa Graff Dominik Spira Ilja Demuth Nathalie van der Velde Lisette C. P. G. M. de Groot Bruce M. Psaty Michelle C. Odden Alison E. Fohner Claudia Langenberg Nicholas J. Wareham Stefania Bandinelli Natasja M. van Schoor Martijn Huisman Qihua Tan Joseph Zmuda Dan Mellström Magnus Karlsson David A. Bennett Aron S. Buchman Philip L. De Jager Andre G. Uitterlinden Uwe Völker Thomas Kocher Alexander Teumer Leocadio Rodriguéz-Mañas Francisco J. García José A. Carnicero Pamela Herd Lars Bertram Claes Ohlsson Joanne M. Murabito David Melzer George A. Kuchel Luigi Ferrucci David Karasik Fernando Rivadeneira Douglas P. Kiel Luke C. Pilling
author_sort	Garan Jones
title	Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
title_short	Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
title_full	Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
title_fullStr	Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
title_full_unstemmed	Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
title_sort	genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c432b68fa4c74f79a795551d0b9372a0
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Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

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