Trigger factor chaperone acts as a mechanical foldase

Proteins fold under mechanical force during co-translational folding at the ribosome. Here, the authors use single molecule magnetic tweezers to study the influence of chaperones on protein folding and show that the ribosomal chaperone trigger factor acts as a mechanical foldase by promoting protein...

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Autores principales:	Shubhasis Haldar, Rafael Tapia-Rojo, Edward C. Eckels, Jessica Valle-Orero, Julio M. Fernandez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c435eaed6d044a0d845d5ba987b97fa9
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spelling	oai:doaj.org-article:c435eaed6d044a0d845d5ba987b97fa92021-12-02T17:06:23ZTrigger factor chaperone acts as a mechanical foldase10.1038/s41467-017-00771-62041-1723https://doaj.org/article/c435eaed6d044a0d845d5ba987b97fa92017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00771-6https://doaj.org/toc/2041-1723Proteins fold under mechanical force during co-translational folding at the ribosome. Here, the authors use single molecule magnetic tweezers to study the influence of chaperones on protein folding and show that the ribosomal chaperone trigger factor acts as a mechanical foldase by promoting protein folding under force.Shubhasis HaldarRafael Tapia-RojoEdward C. EckelsJessica Valle-OreroJulio M. FernandezNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shubhasis Haldar Rafael Tapia-Rojo Edward C. Eckels Jessica Valle-Orero Julio M. Fernandez Trigger factor chaperone acts as a mechanical foldase
description	Proteins fold under mechanical force during co-translational folding at the ribosome. Here, the authors use single molecule magnetic tweezers to study the influence of chaperones on protein folding and show that the ribosomal chaperone trigger factor acts as a mechanical foldase by promoting protein folding under force.
format	article
author	Shubhasis Haldar Rafael Tapia-Rojo Edward C. Eckels Jessica Valle-Orero Julio M. Fernandez
author_facet	Shubhasis Haldar Rafael Tapia-Rojo Edward C. Eckels Jessica Valle-Orero Julio M. Fernandez
author_sort	Shubhasis Haldar
title	Trigger factor chaperone acts as a mechanical foldase
title_short	Trigger factor chaperone acts as a mechanical foldase
title_full	Trigger factor chaperone acts as a mechanical foldase
title_fullStr	Trigger factor chaperone acts as a mechanical foldase
title_full_unstemmed	Trigger factor chaperone acts as a mechanical foldase
title_sort	trigger factor chaperone acts as a mechanical foldase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c435eaed6d044a0d845d5ba987b97fa9
work_keys_str_mv	AT shubhasishaldar triggerfactorchaperoneactsasamechanicalfoldase AT rafaeltapiarojo triggerfactorchaperoneactsasamechanicalfoldase AT edwardceckels triggerfactorchaperoneactsasamechanicalfoldase AT jessicavalleorero triggerfactorchaperoneactsasamechanicalfoldase AT juliomfernandez triggerfactorchaperoneactsasamechanicalfoldase
_version_	1718381636478828544

Trigger factor chaperone acts as a mechanical foldase

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