Effects of intranasal Imunofan administration upon phagocytic activity in treatment of exudative otitis media in children

Exudative otitis media in childhood is most often associated with chronic inflammation in the nasopharyngeal area, with immediate participation of phagocytic cells. Our paper presents the data on evaluation of clinical and immunological efficacy of intranasal Imunofan use included int...

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Autores principales:	E. N. Kologrivova, R. I. Pleshko, N. V. Scherbik, A. V. Starokha, E. Chichinskas
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	intranasal immunotherapy exudative otitis media childhood phagocytes myeloperoxidase cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c4390184dc91446b916542c598aee328
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spelling	oai:doaj.org-article:c4390184dc91446b916542c598aee3282021-11-18T08:03:50ZEffects of intranasal Imunofan administration upon phagocytic activity in treatment of exudative otitis media in children1563-06252313-741X10.15789/1563-0625-2019-5-https://doaj.org/article/c4390184dc91446b916542c598aee3282020-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1720https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XExudative otitis media in childhood is most often associated with chronic inflammation in the nasopharyngeal area, with immediate participation of phagocytic cells. Our paper presents the data on evaluation of clinical and immunological efficacy of intranasal Imunofan use included into complex therapy of exudative otitis media. Dynamic observation (before treatment, 1 and 3 months after treatment) of these parameters included regular evaluation of the neutrophil and monocyte amounts in peripheral blood and in smear imprints from nasal mucosa, determination of myeloperoxidase activity in circulating neutrophils, and the content of interleukin IL-8 and IL-18 in the nasal washouts. The clinical status was assessed using a scoring system, which subjectively reflected the state of the nasopharynx and auditory function. Fourty-three children aged from 3 to 7 years with exudative otitis media associated with chronic adenoiditis were examined. Patients of the first group (22 children) were treated using only conventional approaches (basic therapy). The patients from the second group (21 children) received Imunofan in addition to the basic therapy. The control group consisted of 16 relatively healthy children. Before treatment of the children with exudative otitis media, an increase in the relative content of monocytes in their blood, a decreased activity of myeloperoxidase and lower concentration of IL-8 and IL-18 in the nasal wash was observed in comparison with healthy controls. No differences in severity of clinical symptoms were revealed between the groups of patients. Baseline therapy was not accompanied by positive dynamics in the clinical pattern of the disease. Relative monocytosis and reduced activity of neutrophilic myeloperoxidase persisted in peripheral blood; the concentration of IL-8 and IL-18 in the nasal washings remained low. Following intranasal use of Imunofan, the number of circulating monocytes was restored by the third month from the start of treatment, there was an increased activity of myeloperoxidase registered in blood neutrophils, as well as higher IL-8 and IL-18 concentrations in the nasal washings. Normalization of the phagocytos-related parameters, according to this scoring, was associated with clinical remission of the disease. The revealed relationships between clinical data and the results obtained in the course of laboratory research suggest a positive effect of Imunofan as an agent that may enhance effectiveness of conventional basic therapy of otitis media in children.E. N. KologrivovaR. I. PleshkoN. V. ScherbikA. V. StarokhaE. ChichinskasSPb RAACIarticleintranasal immunotherapyexudative otitis mediachildhoodphagocytesmyeloperoxidasecytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 4, Pp 741-750 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	intranasal immunotherapy exudative otitis media childhood phagocytes myeloperoxidase cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	intranasal immunotherapy exudative otitis media childhood phagocytes myeloperoxidase cytokines Immunologic diseases. Allergy RC581-607 E. N. Kologrivova R. I. Pleshko N. V. Scherbik A. V. Starokha E. Chichinskas Effects of intranasal Imunofan administration upon phagocytic activity in treatment of exudative otitis media in children
description	Exudative otitis media in childhood is most often associated with chronic inflammation in the nasopharyngeal area, with immediate participation of phagocytic cells. Our paper presents the data on evaluation of clinical and immunological efficacy of intranasal Imunofan use included into complex therapy of exudative otitis media. Dynamic observation (before treatment, 1 and 3 months after treatment) of these parameters included regular evaluation of the neutrophil and monocyte amounts in peripheral blood and in smear imprints from nasal mucosa, determination of myeloperoxidase activity in circulating neutrophils, and the content of interleukin IL-8 and IL-18 in the nasal washouts. The clinical status was assessed using a scoring system, which subjectively reflected the state of the nasopharynx and auditory function. Fourty-three children aged from 3 to 7 years with exudative otitis media associated with chronic adenoiditis were examined. Patients of the first group (22 children) were treated using only conventional approaches (basic therapy). The patients from the second group (21 children) received Imunofan in addition to the basic therapy. The control group consisted of 16 relatively healthy children. Before treatment of the children with exudative otitis media, an increase in the relative content of monocytes in their blood, a decreased activity of myeloperoxidase and lower concentration of IL-8 and IL-18 in the nasal wash was observed in comparison with healthy controls. No differences in severity of clinical symptoms were revealed between the groups of patients. Baseline therapy was not accompanied by positive dynamics in the clinical pattern of the disease. Relative monocytosis and reduced activity of neutrophilic myeloperoxidase persisted in peripheral blood; the concentration of IL-8 and IL-18 in the nasal washings remained low. Following intranasal use of Imunofan, the number of circulating monocytes was restored by the third month from the start of treatment, there was an increased activity of myeloperoxidase registered in blood neutrophils, as well as higher IL-8 and IL-18 concentrations in the nasal washings. Normalization of the phagocytos-related parameters, according to this scoring, was associated with clinical remission of the disease. The revealed relationships between clinical data and the results obtained in the course of laboratory research suggest a positive effect of Imunofan as an agent that may enhance effectiveness of conventional basic therapy of otitis media in children.
format	article
author	E. N. Kologrivova R. I. Pleshko N. V. Scherbik A. V. Starokha E. Chichinskas
author_facet	E. N. Kologrivova R. I. Pleshko N. V. Scherbik A. V. Starokha E. Chichinskas
author_sort	E. N. Kologrivova
title	Effects of intranasal Imunofan administration upon phagocytic activity in treatment of exudative otitis media in children
title_short	Effects of intranasal Imunofan administration upon phagocytic activity in treatment of exudative otitis media in children
title_full	Effects of intranasal Imunofan administration upon phagocytic activity in treatment of exudative otitis media in children
title_fullStr	Effects of intranasal Imunofan administration upon phagocytic activity in treatment of exudative otitis media in children
title_full_unstemmed	Effects of intranasal Imunofan administration upon phagocytic activity in treatment of exudative otitis media in children
title_sort	effects of intranasal imunofan administration upon phagocytic activity in treatment of exudative otitis media in children
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/c4390184dc91446b916542c598aee328
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Effects of intranasal Imunofan administration upon phagocytic activity in treatment of exudative otitis media in children

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