CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

Autoreactive T cells are suspected to destroy hypocretin-producing neurons in narcolepsy. Here the authors detect CD8 T cells recognizing narcolepsy-related proteins in healthy individuals and in patients with narcolepsy, and show that the frequency of self-reactive CD8 T cells differs between patie...

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Autores principales:	Natasja Wulff Pedersen, Anja Holm, Nikolaj Pagh Kristensen, Anne-Mette Bjerregaard, Amalie Kai Bentzen, Andrea Marion Marquard, Tripti Tamhane, Kristoffer Sølvsten Burgdorf, Henrik Ullum, Poul Jennum, Stine Knudsen, Sine Reker Hadrup, Birgitte Rahbek Kornum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c43cf63b8c6f40c4b300f382f6e4affb
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spelling	oai:doaj.org-article:c43cf63b8c6f40c4b300f382f6e4affb2021-12-02T15:35:39ZCD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens10.1038/s41467-019-08774-12041-1723https://doaj.org/article/c43cf63b8c6f40c4b300f382f6e4affb2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08774-1https://doaj.org/toc/2041-1723Autoreactive T cells are suspected to destroy hypocretin-producing neurons in narcolepsy. Here the authors detect CD8 T cells recognizing narcolepsy-related proteins in healthy individuals and in patients with narcolepsy, and show that the frequency of self-reactive CD8 T cells differs between patients and controls sharing the same HLA-II risk allele.Natasja Wulff PedersenAnja HolmNikolaj Pagh KristensenAnne-Mette BjerregaardAmalie Kai BentzenAndrea Marion MarquardTripti TamhaneKristoffer Sølvsten BurgdorfHenrik UllumPoul JennumStine KnudsenSine Reker HadrupBirgitte Rahbek KornumNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Natasja Wulff Pedersen Anja Holm Nikolaj Pagh Kristensen Anne-Mette Bjerregaard Amalie Kai Bentzen Andrea Marion Marquard Tripti Tamhane Kristoffer Sølvsten Burgdorf Henrik Ullum Poul Jennum Stine Knudsen Sine Reker Hadrup Birgitte Rahbek Kornum CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
description	Autoreactive T cells are suspected to destroy hypocretin-producing neurons in narcolepsy. Here the authors detect CD8 T cells recognizing narcolepsy-related proteins in healthy individuals and in patients with narcolepsy, and show that the frequency of self-reactive CD8 T cells differs between patients and controls sharing the same HLA-II risk allele.
format	article
author	Natasja Wulff Pedersen Anja Holm Nikolaj Pagh Kristensen Anne-Mette Bjerregaard Amalie Kai Bentzen Andrea Marion Marquard Tripti Tamhane Kristoffer Sølvsten Burgdorf Henrik Ullum Poul Jennum Stine Knudsen Sine Reker Hadrup Birgitte Rahbek Kornum
author_facet	Natasja Wulff Pedersen Anja Holm Nikolaj Pagh Kristensen Anne-Mette Bjerregaard Amalie Kai Bentzen Andrea Marion Marquard Tripti Tamhane Kristoffer Sølvsten Burgdorf Henrik Ullum Poul Jennum Stine Knudsen Sine Reker Hadrup Birgitte Rahbek Kornum
author_sort	Natasja Wulff Pedersen
title	CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
title_short	CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
title_full	CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
title_fullStr	CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
title_full_unstemmed	CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
title_sort	cd8+ t cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c43cf63b8c6f40c4b300f382f6e4affb
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CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

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