Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway

Endothelial cells are the fundamental components of blood vessels that regulate several physiological processes including immune responses, angiogenesis, and vascular tone. Endothelial dysfunction contributes to the development of various diseases such as acute lung injury, and endothelial inflammat...

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Autores principales:	Ji Hu, Ru Chen, Jie An, Yilong Wang, Minglu Liang, Kai Huang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dauricine endothelial dysfunction NF-κB pathway acute lung injury inflammation Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c447b85acdc04187a62610d0806bde36
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spelling	oai:doaj.org-article:c447b85acdc04187a62610d0806bde362021-12-02T00:35:28ZDauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway1663-981210.3389/fphar.2021.758962https://doaj.org/article/c447b85acdc04187a62610d0806bde362021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.758962/fullhttps://doaj.org/toc/1663-9812Endothelial cells are the fundamental components of blood vessels that regulate several physiological processes including immune responses, angiogenesis, and vascular tone. Endothelial dysfunction contributes to the development of various diseases such as acute lung injury, and endothelial inflammation is a vital part of endothelial dysfunction. Dauricine is an extract isolated from Menispermum dauricum DC, a traditional Chinese medical plant that can be used for pharyngitis. In this work, we found that IL-1β-induced overexpression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin was inhibited by dauricine in primary human umbilical vein endothelial cells (HUVECs). Correspondingly, adhesion of human acute monocytic leukemia cell line (THP-1) to HUVECs was decreased by dauricine. Further studies showed that dauricine inhibited the activation of nuclear factor-κB (NF-κB) pathway in HUVECs stimulated with IL-1β. In vivo, dauricine protected mice from lipopolysaccharide (LPS)-induced acute lung injury. In lung tissues, the activation of NF-κB pathway and the expression of its downstream genes (ICAM-1, VCAM-1, and E-selectin) were decreased by dauricine, consistent with what was found in vitro. In summary, we concluded that dauricine could alleviate endothelial inflammation by suppressing NF-κB pathway, which might serve as an effective candidate for diseases related with endothelial inflammation.Ji HuJi HuRu ChenRu ChenJie AnJie AnJie AnYilong WangYilong WangYilong WangMinglu LiangMinglu LiangKai HuangKai HuangFrontiers Media S.A.articledauricineendothelial dysfunctionNF-κB pathwayacute lung injuryinflammationTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dauricine endothelial dysfunction NF-κB pathway acute lung injury inflammation Therapeutics. Pharmacology RM1-950
spellingShingle	dauricine endothelial dysfunction NF-κB pathway acute lung injury inflammation Therapeutics. Pharmacology RM1-950 Ji Hu Ji Hu Ru Chen Ru Chen Jie An Jie An Jie An Yilong Wang Yilong Wang Yilong Wang Minglu Liang Minglu Liang Kai Huang Kai Huang Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
description	Endothelial cells are the fundamental components of blood vessels that regulate several physiological processes including immune responses, angiogenesis, and vascular tone. Endothelial dysfunction contributes to the development of various diseases such as acute lung injury, and endothelial inflammation is a vital part of endothelial dysfunction. Dauricine is an extract isolated from Menispermum dauricum DC, a traditional Chinese medical plant that can be used for pharyngitis. In this work, we found that IL-1β-induced overexpression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin was inhibited by dauricine in primary human umbilical vein endothelial cells (HUVECs). Correspondingly, adhesion of human acute monocytic leukemia cell line (THP-1) to HUVECs was decreased by dauricine. Further studies showed that dauricine inhibited the activation of nuclear factor-κB (NF-κB) pathway in HUVECs stimulated with IL-1β. In vivo, dauricine protected mice from lipopolysaccharide (LPS)-induced acute lung injury. In lung tissues, the activation of NF-κB pathway and the expression of its downstream genes (ICAM-1, VCAM-1, and E-selectin) were decreased by dauricine, consistent with what was found in vitro. In summary, we concluded that dauricine could alleviate endothelial inflammation by suppressing NF-κB pathway, which might serve as an effective candidate for diseases related with endothelial inflammation.
format	article
author	Ji Hu Ji Hu Ru Chen Ru Chen Jie An Jie An Jie An Yilong Wang Yilong Wang Yilong Wang Minglu Liang Minglu Liang Kai Huang Kai Huang
author_facet	Ji Hu Ji Hu Ru Chen Ru Chen Jie An Jie An Jie An Yilong Wang Yilong Wang Yilong Wang Minglu Liang Minglu Liang Kai Huang Kai Huang
author_sort	Ji Hu
title	Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
title_short	Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
title_full	Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
title_fullStr	Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
title_full_unstemmed	Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
title_sort	dauricine attenuates vascular endothelial inflammation through inhibiting nf-κb pathway
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c447b85acdc04187a62610d0806bde36
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Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway

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