Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study
Abstract Periodontal disease is a chronic inflammatory condition that affects various peripheral organs. The periodontal inflamed surface area (PISA) quantifies periodontitis severity and the spread of inflammatory wounds. This study aimed to investigate the association between PISA and high-sensiti...
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Nature Portfolio
2021
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oai:doaj.org-article:c449b3b6364d431dbb91e5e97b5b628a2021-12-02T16:08:07ZPeriodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study10.1038/s41598-021-93872-82045-2322https://doaj.org/article/c449b3b6364d431dbb91e5e97b5b628a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93872-8https://doaj.org/toc/2045-2322Abstract Periodontal disease is a chronic inflammatory condition that affects various peripheral organs. The periodontal inflamed surface area (PISA) quantifies periodontitis severity and the spread of inflammatory wounds. This study aimed to investigate the association between PISA and high-sensitivity C-reactive protein (hs-CRP), a systemic inflammation marker. This study included 250 community-dwelling septuagenarians (69–71 years). We collected information on their medical (e.g., diabetes and dyslipidemia) and dental examinations (e.g., measurement of the probing pocket depth). Generalized linear model analysis was used to explore the association between PISA and hs-CRP levels. There was a significant difference in hs-CRP levels between groups with PISA ≥ 500 and < 500 (p = 0.017). Moreover, the generalized linear model analysis revealed a significant association between PISA and hs-CRP levels (risk ratio = 1.77; p = 0.033) even after adjusting other factors. Further, we found a correlation between PISA and hs-CRP (Spearman’s rank correlation coefficient, rs = 0.181; p = 0.023). Our findings suggest that PISA is an effective index for estimating the effect of periodontitis on the whole body, enabling medical-dental cooperation.Koji MikiMasahiro KitamuraKodai HattaKei KamideYasuyuki GondoMotozo YamashitaMasahide TakedachiTakenori NozakiChiharu FujiharaYoichiro KashiwagiTomoaki IwayamaToshihito TakahashiHitomi SatoYuki MurotaniMai KabayamaYasushi TakeyaYoichi TakamiHiroshi AkasakaKoichi YamamotoKen SugimotoTatsuro IshizakiYukie MasuiHiromi RakugiKazunori IkebeShinya MurakamiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q Koji Miki Masahiro Kitamura Kodai Hatta Kei Kamide Yasuyuki Gondo Motozo Yamashita Masahide Takedachi Takenori Nozaki Chiharu Fujihara Yoichiro Kashiwagi Tomoaki Iwayama Toshihito Takahashi Hitomi Sato Yuki Murotani Mai Kabayama Yasushi Takeya Yoichi Takami Hiroshi Akasaka Koichi Yamamoto Ken Sugimoto Tatsuro Ishizaki Yukie Masui Hiromi Rakugi Kazunori Ikebe Shinya Murakami Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
| description |
Abstract Periodontal disease is a chronic inflammatory condition that affects various peripheral organs. The periodontal inflamed surface area (PISA) quantifies periodontitis severity and the spread of inflammatory wounds. This study aimed to investigate the association between PISA and high-sensitivity C-reactive protein (hs-CRP), a systemic inflammation marker. This study included 250 community-dwelling septuagenarians (69–71 years). We collected information on their medical (e.g., diabetes and dyslipidemia) and dental examinations (e.g., measurement of the probing pocket depth). Generalized linear model analysis was used to explore the association between PISA and hs-CRP levels. There was a significant difference in hs-CRP levels between groups with PISA ≥ 500 and < 500 (p = 0.017). Moreover, the generalized linear model analysis revealed a significant association between PISA and hs-CRP levels (risk ratio = 1.77; p = 0.033) even after adjusting other factors. Further, we found a correlation between PISA and hs-CRP (Spearman’s rank correlation coefficient, rs = 0.181; p = 0.023). Our findings suggest that PISA is an effective index for estimating the effect of periodontitis on the whole body, enabling medical-dental cooperation. |
| format |
article |
| author |
Koji Miki Masahiro Kitamura Kodai Hatta Kei Kamide Yasuyuki Gondo Motozo Yamashita Masahide Takedachi Takenori Nozaki Chiharu Fujihara Yoichiro Kashiwagi Tomoaki Iwayama Toshihito Takahashi Hitomi Sato Yuki Murotani Mai Kabayama Yasushi Takeya Yoichi Takami Hiroshi Akasaka Koichi Yamamoto Ken Sugimoto Tatsuro Ishizaki Yukie Masui Hiromi Rakugi Kazunori Ikebe Shinya Murakami |
| author_facet |
Koji Miki Masahiro Kitamura Kodai Hatta Kei Kamide Yasuyuki Gondo Motozo Yamashita Masahide Takedachi Takenori Nozaki Chiharu Fujihara Yoichiro Kashiwagi Tomoaki Iwayama Toshihito Takahashi Hitomi Sato Yuki Murotani Mai Kabayama Yasushi Takeya Yoichi Takami Hiroshi Akasaka Koichi Yamamoto Ken Sugimoto Tatsuro Ishizaki Yukie Masui Hiromi Rakugi Kazunori Ikebe Shinya Murakami |
| author_sort |
Koji Miki |
| title |
Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
| title_short |
Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
| title_full |
Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
| title_fullStr |
Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
| title_full_unstemmed |
Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
| title_sort |
periodontal inflamed surface area is associated with hs-crp in septuagenarian japanese adults in cross-sectional findings from the sonic study |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c449b3b6364d431dbb91e5e97b5b628a |
| work_keys_str_mv |
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