The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice
Abstract Oxygen supplementation, although a cornerstone of emergency and cardiovascular medicine, often results in hyperoxia, a condition characterized by excessive tissue oxygen which results in adverse cardiac remodeling and subsequent injurious effects to physiological function. Cardiac remodelin...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c4503d6aa34242b783f1a32feb979854 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c4503d6aa34242b783f1a32feb979854 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c4503d6aa34242b783f1a32feb9798542021-12-05T12:14:57ZThe implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice10.1038/s41598-021-02550-22045-2322https://doaj.org/article/c4503d6aa34242b783f1a32feb9798542021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02550-2https://doaj.org/toc/2045-2322Abstract Oxygen supplementation, although a cornerstone of emergency and cardiovascular medicine, often results in hyperoxia, a condition characterized by excessive tissue oxygen which results in adverse cardiac remodeling and subsequent injurious effects to physiological function. Cardiac remodeling is further influenced by various risk factors, including pre-existing conditions and sex. Thus, the purpose of this experiment was to investigate cardiac remodeling in Type I Diabetic (Akita) mice subjected to hyperoxic treatment. Overall, we demonstrated that Akita mice experience distinct challenges from wild type (WT) mice. Specifically, Akita males at both normoxia and hyperoxia showed significant decreases in body and heart weights, prolonged PR, QRS, and QTc intervals, and reduced %EF and %FS at normoxia compared to WT controls. Moreover, Akita males largely resemble female mice (both WT and Akita) with regards to the parameters studied. Finally, statistical analysis revealed hyperoxia to have the greatest influence on cardiac pathophysiology, followed by sex, and finally genotype. Taken together, our data suggest that Type I diabetic patients may have distinct cardiac pathophysiology under hyperoxia compared to uncomplicated patients, with males being at high risk. These findings can be used to enhance provision of care in ICU patients with Type I diabetes as a comorbid condition.Katarina BojkovicJennifer Leigh RodgersRiddhi VichareAsmita NandiHussein MansourFaizan SaleemZain Ul AbidinSahit VanthenapalliFeng ChengSiva Kumar PanguluriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Katarina Bojkovic Jennifer Leigh Rodgers Riddhi Vichare Asmita Nandi Hussein Mansour Faizan Saleem Zain Ul Abidin Sahit Vanthenapalli Feng Cheng Siva Kumar Panguluri The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice |
| description |
Abstract Oxygen supplementation, although a cornerstone of emergency and cardiovascular medicine, often results in hyperoxia, a condition characterized by excessive tissue oxygen which results in adverse cardiac remodeling and subsequent injurious effects to physiological function. Cardiac remodeling is further influenced by various risk factors, including pre-existing conditions and sex. Thus, the purpose of this experiment was to investigate cardiac remodeling in Type I Diabetic (Akita) mice subjected to hyperoxic treatment. Overall, we demonstrated that Akita mice experience distinct challenges from wild type (WT) mice. Specifically, Akita males at both normoxia and hyperoxia showed significant decreases in body and heart weights, prolonged PR, QRS, and QTc intervals, and reduced %EF and %FS at normoxia compared to WT controls. Moreover, Akita males largely resemble female mice (both WT and Akita) with regards to the parameters studied. Finally, statistical analysis revealed hyperoxia to have the greatest influence on cardiac pathophysiology, followed by sex, and finally genotype. Taken together, our data suggest that Type I diabetic patients may have distinct cardiac pathophysiology under hyperoxia compared to uncomplicated patients, with males being at high risk. These findings can be used to enhance provision of care in ICU patients with Type I diabetes as a comorbid condition. |
| format |
article |
| author |
Katarina Bojkovic Jennifer Leigh Rodgers Riddhi Vichare Asmita Nandi Hussein Mansour Faizan Saleem Zain Ul Abidin Sahit Vanthenapalli Feng Cheng Siva Kumar Panguluri |
| author_facet |
Katarina Bojkovic Jennifer Leigh Rodgers Riddhi Vichare Asmita Nandi Hussein Mansour Faizan Saleem Zain Ul Abidin Sahit Vanthenapalli Feng Cheng Siva Kumar Panguluri |
| author_sort |
Katarina Bojkovic |
| title |
The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice |
| title_short |
The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice |
| title_full |
The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice |
| title_fullStr |
The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice |
| title_full_unstemmed |
The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice |
| title_sort |
implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c4503d6aa34242b783f1a32feb979854 |
| work_keys_str_mv |
AT katarinabojkovic theimplicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT jenniferleighrodgers theimplicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT riddhivichare theimplicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT asmitanandi theimplicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT husseinmansour theimplicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT faizansaleem theimplicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT zainulabidin theimplicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT sahitvanthenapalli theimplicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT fengcheng theimplicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT sivakumarpanguluri theimplicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT katarinabojkovic implicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT jenniferleighrodgers implicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT riddhivichare implicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT asmitanandi implicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT husseinmansour implicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT faizansaleem implicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT zainulabidin implicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT sahitvanthenapalli implicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT fengcheng implicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice AT sivakumarpanguluri implicationsofhyperoxiatype1diabetesandsexoncardiovascularphysiologyinmice |
| _version_ |
1718372158142414848 |