PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

IL-7R activation drives early B cell development, but the signalling is unclear. Here the authors show PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B cell development at the pre-pro-B stage in mice.

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Autores principales:	Mei Yu, Yuhong Chen, Hu Zeng, Yongwei Zheng, Guoping Fu, Wen Zhu, Ulrich Broeckel, Praful Aggarwal, Amy Turner, Geoffrey Neale, Cliff Guy, Nan Zhu, Hongbo Chi, Renren Wen, Demin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c452dfc952154a9d82178c4541f18fa3
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spelling	oai:doaj.org-article:c452dfc952154a9d82178c4541f18fa32021-12-02T14:42:33ZPLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development10.1038/s41467-017-01388-52041-1723https://doaj.org/article/c452dfc952154a9d82178c4541f18fa32017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01388-5https://doaj.org/toc/2041-1723IL-7R activation drives early B cell development, but the signalling is unclear. Here the authors show PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B cell development at the pre-pro-B stage in mice.Mei YuYuhong ChenHu ZengYongwei ZhengGuoping FuWen ZhuUlrich BroeckelPraful AggarwalAmy TurnerGeoffrey NealeCliff GuyNan ZhuHongbo ChiRenren WenDemin WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mei Yu Yuhong Chen Hu Zeng Yongwei Zheng Guoping Fu Wen Zhu Ulrich Broeckel Praful Aggarwal Amy Turner Geoffrey Neale Cliff Guy Nan Zhu Hongbo Chi Renren Wen Demin Wang PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development
description	IL-7R activation drives early B cell development, but the signalling is unclear. Here the authors show PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B cell development at the pre-pro-B stage in mice.
format	article
author	Mei Yu Yuhong Chen Hu Zeng Yongwei Zheng Guoping Fu Wen Zhu Ulrich Broeckel Praful Aggarwal Amy Turner Geoffrey Neale Cliff Guy Nan Zhu Hongbo Chi Renren Wen Demin Wang
author_facet	Mei Yu Yuhong Chen Hu Zeng Yongwei Zheng Guoping Fu Wen Zhu Ulrich Broeckel Praful Aggarwal Amy Turner Geoffrey Neale Cliff Guy Nan Zhu Hongbo Chi Renren Wen Demin Wang
author_sort	Mei Yu
title	PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development
title_short	PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development
title_full	PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development
title_fullStr	PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development
title_full_unstemmed	PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development
title_sort	plcγ-dependent mtor signalling controls il-7-mediated early b cell development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c452dfc952154a9d82178c4541f18fa3
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PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

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