Pretreatment body mass index and serum uric acid and albumin levels as prognostic predictors in patients with oral squamous cell carcinoma

Background: Oral squamous cell carcinoma (OSCC) is the most frequently found malignant tumor of the oral cavity, and the annual death rate of OSCC patients has been increasing rapidly among the Taiwanese population. Aim: The aim of this study is to evaluate if poor nutrition is a potential adverse p...

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Autores principales:	Wei-Chin Chang, Cheng-Yu Yang, Yu-Chun Lin, Chun-Shu Lin, Chin-Shan Kuo, Yu-Hsuan Li, Yuan-Wu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	body mass index nutrition uric acid albumin oral squamous cell carcinoma Medicine R Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Acceso en línea:	https://doaj.org/article/c453bdcc462c40259ad946769dc095f5
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spelling	oai:doaj.org-article:c453bdcc462c40259ad946769dc095f52021-11-12T10:24:36ZPretreatment body mass index and serum uric acid and albumin levels as prognostic predictors in patients with oral squamous cell carcinoma1011-456410.4103/jmedsci.jmedsci_325_20https://doaj.org/article/c453bdcc462c40259ad946769dc095f52021-01-01T00:00:00Zhttp://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2021;volume=41;issue=6;spage=295;epage=304;aulast=Changhttps://doaj.org/toc/1011-4564Background: Oral squamous cell carcinoma (OSCC) is the most frequently found malignant tumor of the oral cavity, and the annual death rate of OSCC patients has been increasing rapidly among the Taiwanese population. Aim: The aim of this study is to evaluate if poor nutrition is a potential adverse prognostic factor in patients with OSCC. Methods: This cross-sectional study included 322 patients with OSCC who underwent therapeutic surgical treatment in Taiwan. The pretreatment body mass index (BMI) and serum uric acid and albumin levels were measured as common indicators of the nutritional status, and overall survival (OS) was analyzed using the Kaplan–Meier method and a Cox regression model. Results: The optimal cut-off values were 24.0 kg/m[2], 5.05 mg/dL, and 3.85 g/dL for BMI, serum uric acid, and serum albumin, respectively. The multivariate Cox regression analysis indicated lower BMI (hazard ratio [HR] = 1.557, 95% confidence interval [95% CI]: 1.070–2.265; P = 0.021), lower serum uric acid (HR = 1.857, 95% CI: 1.265–2.724; P = 0.002), and lower serum albumin (HR = 2.011, 95% CI: 1.278–3.163; P = 0.003) as independent and significant prognosticators of OS. Advanced stage, depth of invasion of more than 5 mm, and extranodal extension were prognostic predictors of poor OS. Conclusion: A lower preoperative BMI and lower serum uric acid and albumin levels are predictors of significantly worse survival among OSCC patients. Maintaining a healthy nutritional status is crucial to improving the survival of patients with oral cancer. The treatment for patients with poor nutritional status should be more aggressive and cautious.Wei-Chin ChangCheng-Yu YangYu-Chun LinChun-Shu LinChin-Shan KuoYu-Hsuan LiYuan-Wu ChenWolters Kluwer Medknow Publicationsarticlebody mass indexnutritionuric acidalbuminoral squamous cell carcinomaMedicineRMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENJournal of Medical Sciences, Vol 41, Iss 6, Pp 295-304 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	body mass index nutrition uric acid albumin oral squamous cell carcinoma Medicine R Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
spellingShingle	body mass index nutrition uric acid albumin oral squamous cell carcinoma Medicine R Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Wei-Chin Chang Cheng-Yu Yang Yu-Chun Lin Chun-Shu Lin Chin-Shan Kuo Yu-Hsuan Li Yuan-Wu Chen Pretreatment body mass index and serum uric acid and albumin levels as prognostic predictors in patients with oral squamous cell carcinoma
description	Background: Oral squamous cell carcinoma (OSCC) is the most frequently found malignant tumor of the oral cavity, and the annual death rate of OSCC patients has been increasing rapidly among the Taiwanese population. Aim: The aim of this study is to evaluate if poor nutrition is a potential adverse prognostic factor in patients with OSCC. Methods: This cross-sectional study included 322 patients with OSCC who underwent therapeutic surgical treatment in Taiwan. The pretreatment body mass index (BMI) and serum uric acid and albumin levels were measured as common indicators of the nutritional status, and overall survival (OS) was analyzed using the Kaplan–Meier method and a Cox regression model. Results: The optimal cut-off values were 24.0 kg/m[2], 5.05 mg/dL, and 3.85 g/dL for BMI, serum uric acid, and serum albumin, respectively. The multivariate Cox regression analysis indicated lower BMI (hazard ratio [HR] = 1.557, 95% confidence interval [95% CI]: 1.070–2.265; P = 0.021), lower serum uric acid (HR = 1.857, 95% CI: 1.265–2.724; P = 0.002), and lower serum albumin (HR = 2.011, 95% CI: 1.278–3.163; P = 0.003) as independent and significant prognosticators of OS. Advanced stage, depth of invasion of more than 5 mm, and extranodal extension were prognostic predictors of poor OS. Conclusion: A lower preoperative BMI and lower serum uric acid and albumin levels are predictors of significantly worse survival among OSCC patients. Maintaining a healthy nutritional status is crucial to improving the survival of patients with oral cancer. The treatment for patients with poor nutritional status should be more aggressive and cautious.
format	article
author	Wei-Chin Chang Cheng-Yu Yang Yu-Chun Lin Chun-Shu Lin Chin-Shan Kuo Yu-Hsuan Li Yuan-Wu Chen
author_facet	Wei-Chin Chang Cheng-Yu Yang Yu-Chun Lin Chun-Shu Lin Chin-Shan Kuo Yu-Hsuan Li Yuan-Wu Chen
author_sort	Wei-Chin Chang
title	Pretreatment body mass index and serum uric acid and albumin levels as prognostic predictors in patients with oral squamous cell carcinoma
title_short	Pretreatment body mass index and serum uric acid and albumin levels as prognostic predictors in patients with oral squamous cell carcinoma
title_full	Pretreatment body mass index and serum uric acid and albumin levels as prognostic predictors in patients with oral squamous cell carcinoma
title_fullStr	Pretreatment body mass index and serum uric acid and albumin levels as prognostic predictors in patients with oral squamous cell carcinoma
title_full_unstemmed	Pretreatment body mass index and serum uric acid and albumin levels as prognostic predictors in patients with oral squamous cell carcinoma
title_sort	pretreatment body mass index and serum uric acid and albumin levels as prognostic predictors in patients with oral squamous cell carcinoma
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/c453bdcc462c40259ad946769dc095f5
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Pretreatment body mass index and serum uric acid and albumin levels as prognostic predictors in patients with oral squamous cell carcinoma

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