Spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration

Coordination of diverse individuals often requires sophisticated communications and high-order computational abilities. Microbial populations can exhibit diverse individualistic behaviors, and yet can engage in collective migratory patterns with a spatially sorted arrangement of phenotypes. However,...

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Autores principales:	Yang Bai, Caiyun He, Pan Chu, Junjiajia Long, Xuefei Li, Xiongfei Fu
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	phenotypic diversity bacterial chemotaxis collective behavior pattern formation langevin model agent-based simulation Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c455e94f3b914dbcb0de31da36890ffb
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spelling	oai:doaj.org-article:c455e94f3b914dbcb0de31da36890ffb2021-11-08T17:16:00ZSpatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration10.7554/eLife.673162050-084Xe67316https://doaj.org/article/c455e94f3b914dbcb0de31da36890ffb2021-11-01T00:00:00Zhttps://elifesciences.org/articles/67316https://doaj.org/toc/2050-084XCoordination of diverse individuals often requires sophisticated communications and high-order computational abilities. Microbial populations can exhibit diverse individualistic behaviors, and yet can engage in collective migratory patterns with a spatially sorted arrangement of phenotypes. However, it is unclear how such spatially sorted patterns emerge from diverse individuals without complex computational abilities. Here, by investigating the single-cell trajectories during group migration, we discovered that, despite the constant migrating speed of a group, the drift velocities of individual bacteria decrease from the back to the front. With a Langevin-type modeling framework, we showed that this decreasing profile of drift velocities implies the spatial modulation of individual run-and-tumble random motions, and enables the bacterial population to migrate as a pushed wave front. Theoretical analysis and stochastic simulations further predicted that the pushed wave front can help a diverse population to stay in a tight group, while diverse individuals perform the same type of mean reverting processes around centers orderly aligned by their chemotactic abilities. This mechanism about the emergence of orderly collective migration from diverse individuals is experimentally demonstrated by titration of bacterial chemoreceptor abundance. These results reveal a simple computational principle for emergent ordered behaviors from heterogeneous individuals.Yang BaiCaiyun HePan ChuJunjiajia LongXuefei LiXiongfei FueLife Sciences Publications Ltdarticlephenotypic diversitybacterial chemotaxiscollective behaviorpattern formationlangevin modelagent-based simulationMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	phenotypic diversity bacterial chemotaxis collective behavior pattern formation langevin model agent-based simulation Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	phenotypic diversity bacterial chemotaxis collective behavior pattern formation langevin model agent-based simulation Medicine R Science Q Biology (General) QH301-705.5 Yang Bai Caiyun He Pan Chu Junjiajia Long Xuefei Li Xiongfei Fu Spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration
description	Coordination of diverse individuals often requires sophisticated communications and high-order computational abilities. Microbial populations can exhibit diverse individualistic behaviors, and yet can engage in collective migratory patterns with a spatially sorted arrangement of phenotypes. However, it is unclear how such spatially sorted patterns emerge from diverse individuals without complex computational abilities. Here, by investigating the single-cell trajectories during group migration, we discovered that, despite the constant migrating speed of a group, the drift velocities of individual bacteria decrease from the back to the front. With a Langevin-type modeling framework, we showed that this decreasing profile of drift velocities implies the spatial modulation of individual run-and-tumble random motions, and enables the bacterial population to migrate as a pushed wave front. Theoretical analysis and stochastic simulations further predicted that the pushed wave front can help a diverse population to stay in a tight group, while diverse individuals perform the same type of mean reverting processes around centers orderly aligned by their chemotactic abilities. This mechanism about the emergence of orderly collective migration from diverse individuals is experimentally demonstrated by titration of bacterial chemoreceptor abundance. These results reveal a simple computational principle for emergent ordered behaviors from heterogeneous individuals.
format	article
author	Yang Bai Caiyun He Pan Chu Junjiajia Long Xuefei Li Xiongfei Fu
author_facet	Yang Bai Caiyun He Pan Chu Junjiajia Long Xuefei Li Xiongfei Fu
author_sort	Yang Bai
title	Spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration
title_short	Spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration
title_full	Spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration
title_fullStr	Spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration
title_full_unstemmed	Spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration
title_sort	spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/c455e94f3b914dbcb0de31da36890ffb
work_keys_str_mv	AT yangbai spatialmodulationofindividualbehaviorsenablesanorderedstructureofdiversephenotypesduringbacterialgroupmigration AT caiyunhe spatialmodulationofindividualbehaviorsenablesanorderedstructureofdiversephenotypesduringbacterialgroupmigration AT panchu spatialmodulationofindividualbehaviorsenablesanorderedstructureofdiversephenotypesduringbacterialgroupmigration AT junjiajialong spatialmodulationofindividualbehaviorsenablesanorderedstructureofdiversephenotypesduringbacterialgroupmigration AT xuefeili spatialmodulationofindividualbehaviorsenablesanorderedstructureofdiversephenotypesduringbacterialgroupmigration AT xiongfeifu spatialmodulationofindividualbehaviorsenablesanorderedstructureofdiversephenotypesduringbacterialgroupmigration
_version_	1718441514850320384

Spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration

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