Sophorolipid: A glycolipid biosurfactant as a potential therapeutic agent against COVID-19

Biosurfactants are natural surfactants produced by a variety of microorganisms. In recent years, biosurfactants have garnered a lot of interest due to their biomedical and pharmaceutical applications. Sophorolipids are glycolipids types of biosurfactants produced by selected non-pathogenic yeasts. I...

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Autores principales:	Amita Daverey, Kasturi Dutta, Sanket Joshi, Achlesh Daverey
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	antiviral biosurfactant covid-19 glycolipids sophorolipids sars-cov-2 Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/c45782a6959843098a1cf6e1b97dc830
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spelling	oai:doaj.org-article:c45782a6959843098a1cf6e1b97dc8302021-11-04T15:51:54ZSophorolipid: A glycolipid biosurfactant as a potential therapeutic agent against COVID-192165-59792165-598710.1080/21655979.2021.1997261https://doaj.org/article/c45782a6959843098a1cf6e1b97dc8302021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1997261https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Biosurfactants are natural surfactants produced by a variety of microorganisms. In recent years, biosurfactants have garnered a lot of interest due to their biomedical and pharmaceutical applications. Sophorolipids are glycolipids types of biosurfactants produced by selected non-pathogenic yeasts. In addition to the detergent activity (reduction in surface and interfacial tension), which is commonly utilized by biomedical applications, sophorolipids have shown some unique properties such as, antiviral activity against enveloped viruses, immunomodulation, and anticancer activity. Considering their antiviral activity, the potential of sophorolipids as an antiviral therapy for the treatment of COVID-19 is discussed in this review. Being a surfactant molecule, sophorolipid could solubilize the lipid envelope of SARS-CoV-2 and inactivate it. As an immunomodulator, sophorolipid could attenuate the cytokine storm caused by the SARS-CoV-2 upon infection, and inhibit the progression of COVID-19 in patients. Sophorolipids could also be used as an effective treatment strategy for COVID-19 patients suffering from cancer. However, there is limited research on the use of sophorolipid as a therapeutic agent for the treatment of cancer and viral diseases, and to modulate the immune response. Nevertheless, the multitasking capabilities of sophorolipids make them potential therapeutic candidates for the bench-to-bedside research for the treatment of COVID-19.Amita DavereyKasturi DuttaSanket JoshiAchlesh DavereyTaylor & Francis Grouparticleantiviralbiosurfactantcovid-19glycolipidssophorolipidssars-cov-2BiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antiviral biosurfactant covid-19 glycolipids sophorolipids sars-cov-2 Biotechnology TP248.13-248.65
spellingShingle	antiviral biosurfactant covid-19 glycolipids sophorolipids sars-cov-2 Biotechnology TP248.13-248.65 Amita Daverey Kasturi Dutta Sanket Joshi Achlesh Daverey Sophorolipid: A glycolipid biosurfactant as a potential therapeutic agent against COVID-19
description	Biosurfactants are natural surfactants produced by a variety of microorganisms. In recent years, biosurfactants have garnered a lot of interest due to their biomedical and pharmaceutical applications. Sophorolipids are glycolipids types of biosurfactants produced by selected non-pathogenic yeasts. In addition to the detergent activity (reduction in surface and interfacial tension), which is commonly utilized by biomedical applications, sophorolipids have shown some unique properties such as, antiviral activity against enveloped viruses, immunomodulation, and anticancer activity. Considering their antiviral activity, the potential of sophorolipids as an antiviral therapy for the treatment of COVID-19 is discussed in this review. Being a surfactant molecule, sophorolipid could solubilize the lipid envelope of SARS-CoV-2 and inactivate it. As an immunomodulator, sophorolipid could attenuate the cytokine storm caused by the SARS-CoV-2 upon infection, and inhibit the progression of COVID-19 in patients. Sophorolipids could also be used as an effective treatment strategy for COVID-19 patients suffering from cancer. However, there is limited research on the use of sophorolipid as a therapeutic agent for the treatment of cancer and viral diseases, and to modulate the immune response. Nevertheless, the multitasking capabilities of sophorolipids make them potential therapeutic candidates for the bench-to-bedside research for the treatment of COVID-19.
format	article
author	Amita Daverey Kasturi Dutta Sanket Joshi Achlesh Daverey
author_facet	Amita Daverey Kasturi Dutta Sanket Joshi Achlesh Daverey
author_sort	Amita Daverey
title	Sophorolipid: A glycolipid biosurfactant as a potential therapeutic agent against COVID-19
title_short	Sophorolipid: A glycolipid biosurfactant as a potential therapeutic agent against COVID-19
title_full	Sophorolipid: A glycolipid biosurfactant as a potential therapeutic agent against COVID-19
title_fullStr	Sophorolipid: A glycolipid biosurfactant as a potential therapeutic agent against COVID-19
title_full_unstemmed	Sophorolipid: A glycolipid biosurfactant as a potential therapeutic agent against COVID-19
title_sort	sophorolipid: a glycolipid biosurfactant as a potential therapeutic agent against covid-19
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/c45782a6959843098a1cf6e1b97dc830
work_keys_str_mv	AT amitadaverey sophorolipidaglycolipidbiosurfactantasapotentialtherapeuticagentagainstcovid19 AT kasturidutta sophorolipidaglycolipidbiosurfactantasapotentialtherapeuticagentagainstcovid19 AT sanketjoshi sophorolipidaglycolipidbiosurfactantasapotentialtherapeuticagentagainstcovid19 AT achleshdaverey sophorolipidaglycolipidbiosurfactantasapotentialtherapeuticagentagainstcovid19
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Sophorolipid: A glycolipid biosurfactant as a potential therapeutic agent against COVID-19

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