Immunity to measles virus in diverse population groups

The aim of the study was to assess the measles immunity level among employees of medical organizations of various specialties, young subjects, and neonates. Materials and Methods. The measles immunity status was assessed for all the employees of St. Petersburg State Budgetary Healthcare Institution...

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Autores principales:	A. V. Liubimova, M. D. Zlokazov, L. A. Ivanova, L. YU. Arzamastseva, N. N. Ryzhman, E. N. Kolosovskaya, O. P. Gumilevskaya
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2021
Materias:	measles immunity health-care workers newborn children vaccination prevention Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/c4582ce545f346c8b8a978760ccc9318
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spelling	oai:doaj.org-article:c4582ce545f346c8b8a978760ccc93182021-11-22T07:09:54ZImmunity to measles virus in diverse population groups2220-76192313-739810.15789/2220-7619-ITM-1139https://doaj.org/article/c4582ce545f346c8b8a978760ccc93182021-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1139https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The aim of the study was to assess the measles immunity level among employees of medical organizations of various specialties, young subjects, and neonates. Materials and Methods. The measles immunity status was assessed for all the employees of St. Petersburg State Budgetary Healthcare Institution Maternity Hospital No. 10 (386 subjects), civilian medical staff of the clinics of the Military Medical Academy named after S.M. Kirov (Military Medical Academy) (1399 subjects), cadets of the Military Medical Academy (304 subjects) and 34 neonates. Laboratory testing was performed by using ELISA with test kits “VektoKor-IgG” (RF). Results. Medical workers displayed high total level of protection against measles virus serologically confirmed in 87.5% of the maternity hospital staff and 81.6% of the employees at the Military Medical Academy clinics. No differences in the immune status between the varying categories of medical personnel from the departments of various specialties were revealed. Lower population immunity was observed in the 20-40-year age group. Among the employees of the maternity hospital, the proportion of measles virus seropositive subjects aged 20—40 years was 75.9% (95%, CI 67.2—82.9%), 40—59 years — 91.5% (95%, CI 86.7—94.7%), 60 year and older subjects were all seropositive (95%, CI 94.6—100%). Dual vaccination did not guarantee emergence of effective measles immunity. The majority of seronegative subjects were dually vaccinated, hence, even in case of previous dual measles vaccination, it is necessary to perform a serological examination prior to recruitment to medical facilities. Females comprised more than 90% of medical workers. Therefore, women of fertile age previously dually vaccinated, but immunologically seronegative, are at risk of measles and intrauterine fetal infection, as well as the risk of its development is increased in vaccination age children. It was confirmed by demonstrating that as few as 70.6±15.3% of neonates were immune to the measles virus. The proportion of seronegative infants (29.4±15.3%) was comparable to that one in seronegative subjects aged 20—40 years (24.1±8.1%) working at the maternity hospital. Among the younger age group (aged 18—23 years) such as cadets of the Military Medical Academy, a significantly higher proportion of seronegative individuals was found — 48.3±5.6%, thereby increasing probability for measles outbreak therein. Conclusions. In order to eradicate measles, it is necessary to develop a screening program for detecting antibodies against measles among young and middle-aged subjects.A. V. LiubimovaM. D. ZlokazovL. A. IvanovaL. YU. ArzamastsevaN. N. RyzhmanE. N. KolosovskayaO. P. GumilevskayaSankt-Peterburg : NIIÈM imeni Pasteraarticlemeaslesimmunityhealth-care workersnewborn childrenvaccinationpreventionInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 11, Iss 3, Pp 577-584 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	measles immunity health-care workers newborn children vaccination prevention Infectious and parasitic diseases RC109-216
spellingShingle	measles immunity health-care workers newborn children vaccination prevention Infectious and parasitic diseases RC109-216 A. V. Liubimova M. D. Zlokazov L. A. Ivanova L. YU. Arzamastseva N. N. Ryzhman E. N. Kolosovskaya O. P. Gumilevskaya Immunity to measles virus in diverse population groups
description	The aim of the study was to assess the measles immunity level among employees of medical organizations of various specialties, young subjects, and neonates. Materials and Methods. The measles immunity status was assessed for all the employees of St. Petersburg State Budgetary Healthcare Institution Maternity Hospital No. 10 (386 subjects), civilian medical staff of the clinics of the Military Medical Academy named after S.M. Kirov (Military Medical Academy) (1399 subjects), cadets of the Military Medical Academy (304 subjects) and 34 neonates. Laboratory testing was performed by using ELISA with test kits “VektoKor-IgG” (RF). Results. Medical workers displayed high total level of protection against measles virus serologically confirmed in 87.5% of the maternity hospital staff and 81.6% of the employees at the Military Medical Academy clinics. No differences in the immune status between the varying categories of medical personnel from the departments of various specialties were revealed. Lower population immunity was observed in the 20-40-year age group. Among the employees of the maternity hospital, the proportion of measles virus seropositive subjects aged 20—40 years was 75.9% (95%, CI 67.2—82.9%), 40—59 years — 91.5% (95%, CI 86.7—94.7%), 60 year and older subjects were all seropositive (95%, CI 94.6—100%). Dual vaccination did not guarantee emergence of effective measles immunity. The majority of seronegative subjects were dually vaccinated, hence, even in case of previous dual measles vaccination, it is necessary to perform a serological examination prior to recruitment to medical facilities. Females comprised more than 90% of medical workers. Therefore, women of fertile age previously dually vaccinated, but immunologically seronegative, are at risk of measles and intrauterine fetal infection, as well as the risk of its development is increased in vaccination age children. It was confirmed by demonstrating that as few as 70.6±15.3% of neonates were immune to the measles virus. The proportion of seronegative infants (29.4±15.3%) was comparable to that one in seronegative subjects aged 20—40 years (24.1±8.1%) working at the maternity hospital. Among the younger age group (aged 18—23 years) such as cadets of the Military Medical Academy, a significantly higher proportion of seronegative individuals was found — 48.3±5.6%, thereby increasing probability for measles outbreak therein. Conclusions. In order to eradicate measles, it is necessary to develop a screening program for detecting antibodies against measles among young and middle-aged subjects.
format	article
author	A. V. Liubimova M. D. Zlokazov L. A. Ivanova L. YU. Arzamastseva N. N. Ryzhman E. N. Kolosovskaya O. P. Gumilevskaya
author_facet	A. V. Liubimova M. D. Zlokazov L. A. Ivanova L. YU. Arzamastseva N. N. Ryzhman E. N. Kolosovskaya O. P. Gumilevskaya
author_sort	A. V. Liubimova
title	Immunity to measles virus in diverse population groups
title_short	Immunity to measles virus in diverse population groups
title_full	Immunity to measles virus in diverse population groups
title_fullStr	Immunity to measles virus in diverse population groups
title_full_unstemmed	Immunity to measles virus in diverse population groups
title_sort	immunity to measles virus in diverse population groups
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2021
url	https://doaj.org/article/c4582ce545f346c8b8a978760ccc9318
work_keys_str_mv	AT avliubimova immunitytomeaslesvirusindiversepopulationgroups AT mdzlokazov immunitytomeaslesvirusindiversepopulationgroups AT laivanova immunitytomeaslesvirusindiversepopulationgroups AT lyuarzamastseva immunitytomeaslesvirusindiversepopulationgroups AT nnryzhman immunitytomeaslesvirusindiversepopulationgroups AT enkolosovskaya immunitytomeaslesvirusindiversepopulationgroups AT opgumilevskaya immunitytomeaslesvirusindiversepopulationgroups
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Immunity to measles virus in diverse population groups

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