Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses

Abstract Avian influenza virus is a zoonotic agent that significantly impacts public health and the poultry industry. Monitoring viral evolution and spread is crucial for surveillance and tracing programmes, which are currently based on serological or DNA sequencing-phylogenetics analysis. However,...

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Autores principales:	Alireza Heidari, Irene Righetto, Francesco Filippini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c458a438b64145e8a394b531070a40bb
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spelling	oai:doaj.org-article:c458a438b64145e8a394b531070a40bb2021-12-02T15:07:50ZElectrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses10.1038/s41598-018-20225-32045-2322https://doaj.org/article/c458a438b64145e8a394b531070a40bb2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20225-3https://doaj.org/toc/2045-2322Abstract Avian influenza virus is a zoonotic agent that significantly impacts public health and the poultry industry. Monitoring viral evolution and spread is crucial for surveillance and tracing programmes, which are currently based on serological or DNA sequencing-phylogenetics analysis. However, virus-host interactions, antigenic drift and spreading of viral clades strongly depend on variation in the surface features of capsid proteins. We report here that in silico comparative structural analysis of haemagglutinin can reveal relevant evolutionary fingerprints, particularly when integrated with sequence-based analyses. Phylogenetic analyses of H9 viral strains from wild birds and poultry, performed with different methods, reliably led to clustering of viruses into five main groups. Subsequent comparison of structural features showed congruence between such clustering and surface electrostatic fingerprints. These latter fingerprints relate group-specific variations in electrostatic charges and isocontours to well-known haemagglutinin sites involved in the modulation of immune escape and host specificity. This work suggests that the integration of structural and sequence comparisons may enhance investigations of trends and relevant mechanisms in viral evolution.Alireza HeidariIrene RighettoFrancesco FilippiniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alireza Heidari Irene Righetto Francesco Filippini Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses
description	Abstract Avian influenza virus is a zoonotic agent that significantly impacts public health and the poultry industry. Monitoring viral evolution and spread is crucial for surveillance and tracing programmes, which are currently based on serological or DNA sequencing-phylogenetics analysis. However, virus-host interactions, antigenic drift and spreading of viral clades strongly depend on variation in the surface features of capsid proteins. We report here that in silico comparative structural analysis of haemagglutinin can reveal relevant evolutionary fingerprints, particularly when integrated with sequence-based analyses. Phylogenetic analyses of H9 viral strains from wild birds and poultry, performed with different methods, reliably led to clustering of viruses into five main groups. Subsequent comparison of structural features showed congruence between such clustering and surface electrostatic fingerprints. These latter fingerprints relate group-specific variations in electrostatic charges and isocontours to well-known haemagglutinin sites involved in the modulation of immune escape and host specificity. This work suggests that the integration of structural and sequence comparisons may enhance investigations of trends and relevant mechanisms in viral evolution.
format	article
author	Alireza Heidari Irene Righetto Francesco Filippini
author_facet	Alireza Heidari Irene Righetto Francesco Filippini
author_sort	Alireza Heidari
title	Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses
title_short	Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses
title_full	Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses
title_fullStr	Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses
title_full_unstemmed	Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses
title_sort	electrostatic variation of haemagglutinin as a hallmark of the evolution of avian influenza viruses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c458a438b64145e8a394b531070a40bb
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Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses

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