Loss of appetite in patients with amyotrophic lateral sclerosis is associated with weight loss and anxiety/depression

Abstract Weight loss is common in patients with Amyotrophic lateral sclerosis (ALS), and associated with disease progression. Loss of appetite has been shown to be a contributor to weight loss in patients with amyotrophic lateral sclerosis (ALS). However, the reason of loss of appetite is not clear....

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Autores principales:	Yajun Wang, Shan Ye, Lu Chen, Lu Tang, Dongsheng Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c45a282bbb9841218bf34aa01f44c5e5
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spelling	oai:doaj.org-article:c45a282bbb9841218bf34aa01f44c5e52021-12-02T16:55:34ZLoss of appetite in patients with amyotrophic lateral sclerosis is associated with weight loss and anxiety/depression10.1038/s41598-021-88755-x2045-2322https://doaj.org/article/c45a282bbb9841218bf34aa01f44c5e52021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88755-xhttps://doaj.org/toc/2045-2322Abstract Weight loss is common in patients with Amyotrophic lateral sclerosis (ALS), and associated with disease progression. Loss of appetite has been shown to be a contributor to weight loss in patients with amyotrophic lateral sclerosis (ALS). However, the reason of loss of appetite is not clear. The Council on Nutrition appetite questionnaire (CNAQ) and the simplified nutritional appetite questionnaire (SNAQ) are short and simple appetite assessment tools, which were using in ALS patients. In our study, the CNAQ and SNAQ were translated into Chinese, and their reliability and validity were tested. The Chinese version of the CNAQ (CNAQ-C) presented more appropriate reliability and validity than the SNAQ. Among the 94 ALS patients, 50 patients (53.2%) had loss of appetite, and we found that anxiety and/or depression contributed to the loss of appetite in the ALS patients. We reconfirmed that loss of appetite was associated with greater weight loss but not with clinical features of ALS. The loss of appetite caused by emotional problems in ALS patients should be taken seriously, and early intervention should be implemented to reduce weight loss.Yajun WangShan YeLu ChenLu TangDongsheng FanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yajun Wang Shan Ye Lu Chen Lu Tang Dongsheng Fan Loss of appetite in patients with amyotrophic lateral sclerosis is associated with weight loss and anxiety/depression
description	Abstract Weight loss is common in patients with Amyotrophic lateral sclerosis (ALS), and associated with disease progression. Loss of appetite has been shown to be a contributor to weight loss in patients with amyotrophic lateral sclerosis (ALS). However, the reason of loss of appetite is not clear. The Council on Nutrition appetite questionnaire (CNAQ) and the simplified nutritional appetite questionnaire (SNAQ) are short and simple appetite assessment tools, which were using in ALS patients. In our study, the CNAQ and SNAQ were translated into Chinese, and their reliability and validity were tested. The Chinese version of the CNAQ (CNAQ-C) presented more appropriate reliability and validity than the SNAQ. Among the 94 ALS patients, 50 patients (53.2%) had loss of appetite, and we found that anxiety and/or depression contributed to the loss of appetite in the ALS patients. We reconfirmed that loss of appetite was associated with greater weight loss but not with clinical features of ALS. The loss of appetite caused by emotional problems in ALS patients should be taken seriously, and early intervention should be implemented to reduce weight loss.
format	article
author	Yajun Wang Shan Ye Lu Chen Lu Tang Dongsheng Fan
author_facet	Yajun Wang Shan Ye Lu Chen Lu Tang Dongsheng Fan
author_sort	Yajun Wang
title	Loss of appetite in patients with amyotrophic lateral sclerosis is associated with weight loss and anxiety/depression
title_short	Loss of appetite in patients with amyotrophic lateral sclerosis is associated with weight loss and anxiety/depression
title_full	Loss of appetite in patients with amyotrophic lateral sclerosis is associated with weight loss and anxiety/depression
title_fullStr	Loss of appetite in patients with amyotrophic lateral sclerosis is associated with weight loss and anxiety/depression
title_full_unstemmed	Loss of appetite in patients with amyotrophic lateral sclerosis is associated with weight loss and anxiety/depression
title_sort	loss of appetite in patients with amyotrophic lateral sclerosis is associated with weight loss and anxiety/depression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c45a282bbb9841218bf34aa01f44c5e5
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_version_	1718382825301868544

Loss of appetite in patients with amyotrophic lateral sclerosis is associated with weight loss and anxiety/depression

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